[1]梁雪,宾金秀,黄祖美,等.胃复康颗粒对Hp VG湿热证患者胃黏膜p38MAPK及ATF2蛋白表达的影响[J].西部中医药,2019,32(05):4-8.
　LIANG Xue,BIN Jinxiu,HUANG Zumei,et al.Effects of WeiFuKang Granules on the Expressions of ATF2 Protein and p38MAPK in Gastric Mucosa of the Patients with Hp VG of Damp-heat Pattern[J].Western Journal of Traditional Chinese Medicine,2019,32(05):4-8.
点击复制

胃复康颗粒对Hp VG湿热证患者胃黏膜p38MAPK及ATF2蛋白表达的影响
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年05期
页码:
4-8
栏目:
出版日期:
2019-05-15

文章信息/Info

Title:
Effects of WeiFuKang Granules on the Expressions of ATF2 Protein and p38MAPK in Gastric Mucosa of the Patients with Hp VG of Damp-heat Pattern
文章编号:
1004-6852(2019)05-0004-05
作者:
梁雪1，宾金秀2，黄祖美1，王鹏1，卢杰夫1，刘熙荣1，周德丽1，郑超伟1，以敏1，王伟1，苏攀1
1 广西中医药大学第一附属医院脾胃科，广西 南宁 530000； 2 宜州市中医医院内三科
Author(s):
LIANG Xue1, BIN Jinxiu2, HUANG Zumei1, WANG Peng1, LU Jiefu1, LIU Xirong1, ZHOU Deli1, ZHENG Chaowei1, YI Min1, WANG Wei1, SU Pan1
1 Department of Spleen and Stomach, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530000, China; 2 The Third Department of Internal Medicine, Yizhou City TCM Hospital
关键词:
胃炎; 隆起糜烂型; 幽门螺杆菌感染; p38MAPK; ATF2; 胃复康颗粒
Keywords:
gastritis;  uplift erosive type;  Hp infection;  p38MAPK;  ATF2;  WeiFuKang granules
分类号:
R573.1
摘要:
目的：探讨胃复康颗粒对幽门螺杆菌相关性疣状胃炎(Hp VG)湿热证患者胃黏膜病理及p38MAPK、ATF2蛋白表达的影响。方法：将Hp VG湿热证患者135例随机分为中药组、联合组及西药组各45例，中药组予胃复康颗粒1袋/次，2次/d；西药组予泮托拉唑钠肠溶片每次1片，1次/d。联合组同时服用中药及西药。3组疗程均为6周。采用定位活检法取得治疗前后胃黏膜病变标本，用HE染色观察胃黏膜病理组织学变化情况；免疫组化Western blot法检测p38MAPK及ATF2蛋白表达情况。结果：3组患者胃黏膜病理改善总有效率中药组为82.2%、联合组为88.9%、西药组为73.3%，中药组、联合组改善优于西药组（P＜0.05)，中药组与联合组间比较差异无统计学意义（P＞0.05)。治疗后3组患者胃黏膜p38MAPK均较治疗前降低（P＜0.05)，联合组较西药组降低明显（P＜0.05)，与中药组比较效果相当（P＞0.05)。中药组、联合组ATF2蛋白表达较治疗前及西药组降低（P＜0.05)，西药组较治疗前变化不明显（P＞0.05)；联合组与中药组比较效果相当（P＞0.05)。结论：胃复康颗粒联合西药可能通过下调p38MAPK及ATF2蛋白表达，抑制p38MAPK/ATF2通路，减少下游炎症因子释放，起到减轻Hp VG湿热证患者炎症反应的作用。
Abstract:
Objective: To discuss the effects of WeiFuKang granules on the pathology of gastric mucosa, the expressions of ATF2 protein, p38MAPK of the patients with Hp-related verrucosa gastritis(Hp VG) of damp-heat pattern. Methods: All 135 patients were randomized into herbs group, the combination group and Western medicine group, 45 cases each group, the herbs group were given WeiFuKang granules, one bag each time, twice each day; Western medicine group took pantoprazole sodium enteric-coated tablets, one pill each time, once each day. The combination group took herbs and Western medicine simultaneously, the course was six weeks. Localization biopsy was used to obtain pathological specimen of gastric mucosa, HE staining was adopted to observe histopathological changes of gastric mucosa; Western blot method to detect the expressions of ATF2 protein and p38MAPK. Results: Total effective rates of pathological improvements of gastric mucosa in herbs group were 82.2%, the combination group 88.9% and the Western medicine group 73.3%, the herbs group and the combination group were superior to Western medicine group in the improvements (P＜0.05), the difference had no statistical meaning in the herbs group and the combination group(P＞0.05). After treating, p38MAPK of gastric mucosa in three groups lowered compared with before treating (P＜0.05), the combination group was lower than Western medicine group obviously(P＜0.05), compared with the herbs group, the improvement effects were similar(P＞0.05). ATF2 proteins of the herbs group and the combination group reduced compared with before treating and Western medicine group(P＜0.05), the changes of Western medicine group were not obvious than before treating(P＞0.05), the combination group was equivalent to the herbs group(P＞0.05). Conclusion: WeiFuKang granules combined with Western medicine could mitigate inflammatory reaction of the patients through down-regulating the expressions of ATF2 protein and p38MAPK, inhibiting p38MAPK/ATF2 pathway and reducing the release of downstream inflammatory factor.

相似文献/References:

[1]尤海鹰.制萎煎治疗脾胃虚弱型慢性萎缩性胃炎40例[J].西部中医药,2013,26(03):84.
　YOU Haiying.ZhiWeiJian in Treating 40 Cases of Chronic Atrophic Gastritis of Spleen-stomach Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2013,26(05):84.
[2]马继利.中西药物联用治疗慢性萎缩性胃炎58例[J].西部中医药,2013,26(06):91.
　MA Jili.Treatment for 58 Cases of Chronic Atrophic Gastritis with Integrative Medicines[J].Western Journal of Traditional Chinese Medicine,2013,26(05):91.
[3]李耿.摩罗丹联合维生素B12治疗慢性萎缩性胃炎伴异型增生的临床观察[J].西部中医药,2012,25(07):11.
　LI Geng.Clinical Observation on MoLuoDan and Vitamin B12 in the Treatment of Chronic Atrophic Gastritis and Dysplasia[J].Western Journal of Traditional Chinese Medicine,2012,25(05):11.
[4]董莉莉,王军燕,刘安国,等.针灸治疗急性胃炎的临床选穴规律研究*[J].西部中医药,2013,26(11):129.
　DONG Lili,WANG Junyan,LIU Anguo,et al.Study on Acupoint Selection for Treating Acute Gastritis with Acupuncture[J].Western Journal of Traditional Chinese Medicine,2013,26(05):129.
[5]李镇,郑亮△.“治中焦如衡”在慢性胃炎治疗中的意义[J].西部中医药,2014,27(03):98.
　LI Zhen,ZHENG Liang.Analysis of the Meaning of "Treating Middle Energizer by Achieving Relative Equilibrium" in the Therapy Against Chronic Gastritis[J].Western Journal of Traditional Chinese Medicine,2014,27(05):98.
[6]石天玙.清胃化湿汤治疗慢性胃炎 31 例[J].西部中医药,2014,27(08):65.
[7]巩小丽,张菡△,严艳.枳实消痞丸化裁治疗慢性萎缩性胃炎60例[J].西部中医药,2014,27(10):100.
[8]刘启泉,王志坤△,李博林.达立通联合三联杀菌疗法根除慢性胃炎幽门螺旋杆菌感染的临床观察[J].西部中医药,2014,27(12):91.
[9]党民卿,指导：王道坤.王道坤教授治疗慢性萎缩性胃炎癌前病变的经验[J].西部中医药,2015,28(02):37.
[10]彭海平,保继琼,赵敏,等.加味半夏泻心汤治疗幽门螺杆菌相关性萎缩性胃炎32例[J].西部中医药,2015,28(02):94.

备注/Memo

备注/Memo:
收稿日期：2018-12-07 *基金项目：广西壮族自治区教育厅高校科研项目(编号 YB2014187)。 作者简介：梁雪(1968—)，女，硕士学位，主任医师，教授。研究方向：脾胃病的中医药防治及消化系统疾病的内镜下诊治。
更新日期/Last Update: 2019-05-15