[1]沈金凤,刘妍.当归芍药颗粒治疗原发性痛经临床观察[J].西部中医药,2019,32(06):69-71.
　SHEN Jinfeng,LIU Yan.Clinical Observation on Danggui Shaoyao Granules in the Treatment for Primary Dysmenorrhea[J].Western Journal of Traditional Chinese Medicine,2019,32(06):69-71.
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当归芍药颗粒治疗原发性痛经临床观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年06期
页码:
69-71
栏目:
出版日期:
2019-06-15

文章信息/Info

Title:
Clinical Observation on Danggui Shaoyao Granules in the Treatment for Primary Dysmenorrhea
文章编号:
1004-6852(2019)06-0069-03
作者:
沈金凤，刘妍
北京中医医院顺义医院，北京 顺义101300
Author(s):
SHEN Jinfeng, LIU Yan
Shunyi Hospital of Beijing TCM Hospital, Beijing 101300, China
关键词:
痛经; 原发性; 当归芍药颗粒; 氧化应激反应
Keywords:
dysmenorrhea;  primary;  Danggui Shaoyao granules;  oxidative stress
分类号:
R271.11+3
文献标志码:
B
摘要:
目的：观察当归芍药颗粒治疗原发性痛经的临床疗效及对血清超氧化物歧化酶(SOD)脂质过氧化物(MDA)、谷胱甘肽过氧化物酶(GSH-PX)的影响。方法：将58例患者随机分为2组，每组28例，2组均给予布洛芬缓释片治疗，观察组同时服用当归芍药颗粒，连续治疗4个月经周期。观察2组治疗前后临床疗效、痛经视觉模拟评分法(VAS)评分、疼痛持续时间，以及血清SOD、MDA、GSH-PX水平。结果：总有效率观察组为92.86%，对照组为75.00%，2组比较差异有统计学意义(P＜0.05)。血清SOD、MDA和GSH-PX及VAS评分、疼痛持续时间治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后2组组间比较差异有统计学意义(P＜0.05)。2组在治疗期间均未发生严重不良反应。结论：当归芍药颗粒能明显改善原发性痛经患者的疼痛程度和持续时间，改善机体氧化应激状态。
Abstract:
Objective: To survey clinical effects of Danggui Shaoyao granules in the treatment for primary dysmenorrhea, and its effects on SOD, MDA and GSH-PX. Methods: All 58 patients were randomized into two groups, 28 cases each group, both groups took Ibuprofen sustained release tablets, the observation group took Danggui Shaoyao granules for four menstrual cycles consecutively. To observe the levels of SOD, MDA and GSH-PX, VAS scores, pain duration and clinical effects in both groups. Results: Total effective rate of the observation group was 92.86%, higher than 75.00% of the control group, and the difference showed statistical meaning (P＜0.05). The difference was statistically significant in the comparisons of the levels of SOD, MDA and GSH-PX, VAS scores and pain duration within two groups before and after treating (P＜0.05); the difference showed statistical meaning in the comparisons between both groups after treating (P＜0.05). No severe adverse reaction happened in both groups during therapeutic period. Conclusion: Danggui Shaoyao granules could notably improve pain degrees and duration of the patients, and oxidative stress of human body.

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备注/Memo

备注/Memo:
收稿日期：2018-10-26作者简介：沈金凤(1967—)，女，副主任医师。研究方向：妇科疾病的中西医结合诊治。
更新日期/Last Update: 2019-06-15