[1]薛恩忠,李慧婷,刘春丽.加味丹参饮联用替格瑞洛对冠心病心脏功能、hs-CRP、NT-proBNP及Fib的影响[J].西部中医药,2019,32(06):83-85.
　XUE Enzhong,LI Huiting,LIU Chunli.Influence of Modified Danshen Drink and Ticagrelor on Cardiac Function,hs-CRP, NT-proBNP and Fib of Coronary Heart Disease[J].Western Journal of Traditional Chinese Medicine,2019,32(06):83-85.
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加味丹参饮联用替格瑞洛对冠心病心脏功能、hs-CRP、NT-proBNP及Fib的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年06期
页码:
83-85
栏目:
出版日期:
2019-06-15

文章信息/Info

Title:
Influence of Modified Danshen Drink and Ticagrelor on Cardiac Function,hs-CRP, NT-proBNP and Fib of Coronary Heart Disease
文章编号:
1004-6852(2019)06-0083-03
作者:
薛恩忠，李慧婷，刘春丽
延安市人民医院，陕西 延安 716000
Author(s):
XUE Enzhong, LI Huiting, LIU Chunli
Yan′an City People′s Hospital, Yan′an 716000, China
关键词:
冠心病; 加味丹参饮; 替格瑞洛; 心功能; 高敏C反应蛋白; N端脑钠肽前体; 纤维蛋白原
Keywords:
coronary heart disease;  modified Danshen drink;  ticagrelor;  cardiac function;  hs-CRP;  NT-proBNP;  Fib
分类号:
R541.4
文献标志码:
B
摘要:
目的：观察加味丹参饮联用替格瑞洛对冠心病心脏功能、高敏C反应蛋白(hs-CRP)、N端脑钠肽前体(NT-proBNP)及纤维蛋白原(Fib)的影响。方法：将79例患者按就诊的先后顺序随机分为观察组39例、对照组40例。对照组口服替格瑞洛治疗，90 mg/次，1次/d；观察组联用加味丹参饮治疗。比较2组临床疗效，血浆hs-CRP、NT-proBNP、Fib水平、心功能以及并发症发生率。结果：总有效率观察组为92.31%(36/39)，对照组为77.50%(31/40)，2组比较差异有统计学意义(P＜0.05)；并发症发生率观察组为12.82%(5/39)，对照组为32.50%(13/40)，2组比较差异有统计学意义(P＜0.05)。左心室射血分数、左心室舒张末期内径、左心室后壁厚度治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较差异也有统计学意义(P＜0.05)。血浆hs-CRP、NT-proBNP、Fib水平治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较差异也有统计学意义(P＜0.05)。结论：加味丹参饮联用替格瑞洛可以显著提高冠心病患者的临床治疗效果，改善心脏功能，降低血浆hs-CRP、NT-proBNP、Fib水平，且可降低并发症发生率。
Abstract:
Objective: To observe the effects of modified Danshen drink and ticagrelor on cardiac function, hs-CRP, NT-proBNP and Fib of coronary heart disease (CHD). Methods: All 79 patients were divided into 39 cases of the observation group and 40 cases of the control group according to visiting order. The control group was given ticagrelor, 90 mg each time, once each day; and the observation group took modified Danshen drink. To compare clinical effects, the levels of hs-CRP, NT-proBNP and Fib, cardiac function and the incidence of the complications. Results: Total effective rate of the observation group was 92.31% (36/39), higher than 77.50% (31/40) of the control group, and the difference was statistically significant (P＜0.05); the incidence of the complications in the observation group was 12.82% (5/39), lower than 32.50% (13/40) of the control group, and the difference showed statistical meaning (P＜0.05). The difference could be found in left ventricular ejection fraction (LVEF), left ventricular end diastolic dimension (LVEDD) and left ventricular posterior wall thickness (LVPWT) within two groups before and after treating (P＜0.05); the difference had statistical meaning between both groups after treating (P＜0.05). The difference was statistically significant in the levels of hs-CRP, NT-proBNP and Fib within two groups before and after treating (P＜0.05); the difference had statistical meaning between both groups after treating(P＜0.05). Conclusion: Modified Danshen drink and ticagrelor could notably raise therapeutic effects of CHD patients, improve cardiac function, lower the levels of hs-CRP, NT-proBNP and Fib, and reduce the incidence of the complications.

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备注/Memo

备注/Memo:
收稿日期：2018-12-01作者简介：薛恩忠(1978—)，男，副主任医师。研究方向：心血管病的临床诊治。
更新日期/Last Update: 2019-06-15