[1]冯芳,齐 艳,董晨明.清胰汤胃管注入联合血必净注射液治疗重症急性胰腺炎80例[J].西部中医药,2019,32(06):98-101.
　FENG Fang,QI Yan,DONG Chenming.Treating 80 Patients Suffering Severe Acute Pancreatitis by Gastric Tube Injection of Qingyi Decoction and Xuebijing Injection[J].Western Journal of Traditional Chinese Medicine,2019,32(06):98-101.
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清胰汤胃管注入联合血必净注射液治疗重症急性胰腺炎80例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年06期
页码:
98-101
栏目:
出版日期:
2019-06-15

文章信息/Info

Title:
Treating 80 Patients Suffering Severe Acute Pancreatitis by Gastric Tube Injection of Qingyi Decoction and Xuebijing Injection
文章编号:
1004-6852(2018)06-0098-04
作者:
冯芳，齐 艳，董晨明
兰州大学第二医院，甘肃 兰州 730030
Author(s):
FENG Fang, QI Yan, DONG Chenming
Lanzhou University Second Hospital, Lanzhou 730030, China
关键词:
重症急性胰腺炎; 血必净注射液; 清胰汤; 胃管
Keywords:
severe acute pancreatitis; Xuebijing injection;  Qingyi decoction;  gastric tube
分类号:
R657.5+1
文献标志码:
B
摘要:
目的:观察清胰汤胃管注入联合血必净注射液治疗重症急性胰腺炎临床疗效。方法：将160例患者按就诊顺序随机分为对照组80例和观察组80例，2组均给予西医综合治疗，观察组加用清胰汤胃管注入合血必净注射液治疗，比较2组患者病情改善时间，治疗前后中医证候积分、白细胞(WBC)计数、血尿淀粉酶、炎症因子、肠道黏膜屏障指标水平及死亡率。结果：腹痛缓解时间、腹胀缓解时间、胃肠功能恢复时间、机械通气撤机时间2组比较，差异有统计学意义(P＜0.05)。腹痛胀满、恶心呕吐、日晡潮热、口干尿赤、舌质红苔黄腻、脉洪大等中医证候积分治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较差异也有统计学意义(P＜0.05)。WBC计数和血尿淀粉酶水平治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较差异也有统计学意义(P＜0.05)。IL-6、hs-CRP、TNF-α等炎症相关因子水平治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较差异也有统计学意义(P＜0.05)。内毒素、DAO、D-乳酸等肠道黏膜功能指标水平治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较差异也有统计学意义(P＜0.05)。住院期间死亡率对照组、观察组分别为7.50%(6/80)、0.00%(0/80)，2组比较差异有统计学意义(P＜0.05)。结论：血必净注射液合清胰汤胃管注入治疗重症急性胰腺炎可有效促进临床症状缓解，抑制白细胞和血尿淀粉酶释放，拮抗局部炎症反应水平，保护肠道黏膜功能，并有助于降低死亡风险。
Abstract:
Objective: To observe clinical effects of gastric tube injection of Qingyi decoction and Xuebijing injection in the treatment for severe acute pancreatitis (SAP). Methods: All 160 patients were randomized into the control group and the observation group according to the visiting order, 80 cases each group, both groups accepted comprehensive treatment of Western medicine, and the observation group were treated by Qingyi decoction and Xuebijing injection, to compare the improvement time of disease conditions, TCM syndrome scores before and after treating, WBC counting, hematuria amylase, inflammatory factor, the levels of intestinal barrier indexes and mortality rate between both groups. Results: The difference could be found in the remission time of abdominal pain, the remission time of abdominal distension, the recovery time of gastrointestinal function and the withdrawal time of mechanical ventilation (P＜0.05). The difference was statistically significant in TCM syndrome scores including abdominal pain and distension, nausea and vomiting, afternoon tidal fever, dry mouth and hematuresis, red tongue, yellow and greasy fur, large and bounding pulse and others within two groups before and after treating (P＜0.05); the difference showed statistical meaning between both groups after treating (P＜0.05). The difference had statistical meaning in WBC counting and the levels of blood and urine amylase within two groups before and after treating (P＜0.05); there was a significant difference between both groups after treating (P＜0.05). The difference was statistically significant in the levels of IL-6, hs-CRP, TNF-α and others within two groups before and after treating (P＜0.05); the difference had statistical meaning between both groups after treating (P＜0.05). The difference had statistical meaning in the levels of the indexes related to intestinal mucosal function including endotoxin, DAO and D-lactate and others within two groups before and after treating (P＜0.05); the difference had statistical meaning between both groups after treating(P＜0.05). Mortality rates of the control group and the observation group during the hospitalization period were 7.50% (6/80) and 0.00%(0/80) respectively, and the difference had statistical meaning (P＜0.05). Conclusion: Xuebijing injection combined with gastric tube injection of Qingyi decoction in the treatment for SAP could relieve clinical symptoms rapidly and effectively, inhibit the release of leukocyte, blood and urine amylase, fight against local inflammatory reaction, protect intestinal mocusal function, and it could help reduce the risk of death.

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备注/Memo

备注/Memo:
收稿日期：2018-08-27*基金项目：兰州市城关区科技计划项目(编号2014-7-2)。作者简介：冯芳(1982—)，女， 硕士学位，主治医师。研究方向：急危重症。
更新日期/Last Update: 2019-06-15