[1]杨维杰,任伯达,周春楠,等.补肾通络方治疗糖尿病周围神经病变临床研究[J].西部中医药,2021,34(09):95-98.[doi:10.12174/j.issn.2096-9600.2021.09.26]
　YANG Weijie,REN Boda,ZHOU Chunnan,et al.Clinical Study on Kidney-tonifying Collaterals-dredging Prescription in Treating Diabetic Peripheral Neuropathy[J].Western Journal of Traditional Chinese Medicine,2021,34(09):95-98.[doi:10.12174/j.issn.2096-9600.2021.09.26]
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补肾通络方治疗糖尿病周围神经病变临床研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年09期
页码:
95-98
栏目:
出版日期:
2021-09-15

文章信息/Info

Title:
Clinical Study on Kidney-tonifying Collaterals-dredging Prescription in Treating Diabetic Peripheral Neuropathy
作者:
杨维杰1, 任伯达2, 周春楠2, 刘晓2
1.甘肃中医药大学附属医院，甘肃 兰州 730020
2.甘肃中医药大学
Author(s):
YANG Weijie1, REN Boda2, ZHOU Chunnan2, LIU Xiao2
1.Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730020, China
2.Gansu University of Chinese Medicine
关键词:
糖尿病周围神经病变; 阴虚兼瘀证; 补肾通络方; 临床研究
Keywords:
DPN; deficiency complicated with stasis pattern; kidney-tonifying collateral-dredging prescription; clinical study
分类号:
R587.2
DOI:
10.12174/j.issn.2096-9600.2021.09.26
摘要:
目的观察补肾通络方联合甲钴胺对阴虚兼瘀型糖尿病周围神经病变（diabetic peripheral neuropathy，DPN）患者症状及相关指标的干预效果。 方法将糖尿病周围神经病变阴虚兼瘀型患者60例随机分为两组各30例，试验组予甲钴胺+补肾通络方治疗，对照组予甲钴胺治疗，共治疗12周。观察两组患者治疗前后中医症状积分、多伦多临床评分系统（Toronto clinical scoring system，TCSS）评分、糖化血红蛋白（glycosylated hemoglobin，HbA1c）、空腹血糖（fasting plasma glucose，FPG）、餐后2 h血糖（2 h postprandial blood glucose，2hPG）及正中神经、腓总神经感觉传导速度（sensory nerve conduction velocity,SNCV）和运动传导速度（motor nerve conduction velocity,MNCV）。 结果1）试验组、对照组治疗前后中医症状积分、TCSS、FPG、2hPG、HbAlc及双侧腓总、正中神经MNCV、SNCV均较治疗前改善，差异有统计学意义（P＜0.05）；2）两组治疗后中医症状积分、TCSS、FPG、2hPG、HbAlc、双侧腓总神经MNCV、双侧正中神经SNCV比较差异有统计学意义（P＜0.05）。3）试验过程中两组均未见肝肾功能损害，未见低血糖反应。 结论补肾通络方联合甲钴胺治疗阴虚兼瘀型糖尿病周围神经病变效果优于单纯甲钴胺治疗，且安全性较好。
Abstract:
ObjectiveTo observe the intervention effects of kidney-tonifying collateral-dredging prescription joined with mecobalamin on the symptoms and the related indexes in the patients with DPN of Yin deficiency complicated with stasis pattern. MethodsSixty patients were randomized into two groups, 30 cases in each group, the experiment group took mecobalamin and kidney-tonifying collateral-dredging prescription, while the control group accepted oral administration of mecobalamin, both groups were treated for 12 weeks. To observe TCM symptom score, TCSS, HbA1c, FPG, 2hPG, SNCV and MNCV of median nerve and common peroneal nerve before and after treating between both groups. Results1) The difference had statistical meaning in TCM symptom scores, TCSS, FPG, 2hPG, HbA1c, SNCV and MNCV of bilateral median nerve and common peroneal nerve before and after treating between the experiment group and the control group (P<0.05). 2) The difference was statistically significant in TCM symptom score, TCSS, FPG, 2hPG, HbA1c, SNCV and MNCV of median nerve and common peroneal nerve between both groups after treating (P<0.05). 3)No damage to liver and kidney function happened during the process and no hypoglycemic reaction occurred in both groups. ConclusionThe effects of kidney-tonifying collateral-dredging prescription joined with mecobalamin in treating DPN of Yin deficiency complicated with stasis pattern are superior to these of only mecobalamin, and the therapy shows better safety.

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备注/Memo

备注/Memo:
杨维杰（1980—），男，硕士学位，副主任医师。研究方向：内分泌系统疾病中西医结合防治研究。
更新日期/Last Update: 2021-09-15