[1]杜丽明,李广鉴,孙秋,等.门静脉高压性胃病与中医证型及PLT、CHE、D-二聚体的相关性研究[J].西部中医药,2022,35(04):120-123.[doi:10.12174/j.issn.2096-9600.2022.04.28]
　DU Liming,LI Guangjian,SUN Qiu,et al.Correlation between Portal Hypertension Gastropathy, TCM Patterns and PLT, CHE, D-dimer[J].Western Journal of Traditional Chinese Medicine,2022,35(04):120-123.[doi:10.12174/j.issn.2096-9600.2022.04.28]
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门静脉高压性胃病与中医证型及PLT、CHE、D-二聚体的相关性研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年04期
页码:
120-123
栏目:
出版日期:
2022-04-15

文章信息/Info

Title:
Correlation between Portal Hypertension Gastropathy, TCM Patterns and PLT, CHE, D-dimer
作者:
杜丽明1, 李广鉴1, 孙秋1, 王文鸽1, 何俗非2
1.开滦总医院,河北 唐山 063000
2.天津中医药大学
Author(s):
DU Liming1, LI Guangjian1, SUN Qiu1, WANG Wenge1, HE Sufei2
1.Kailuan General Hospital, Tangshan 063000, China
2.Tianjin University of Traditional Chinese Medicine
关键词:
门静脉高压性胃病; 中医证型; 胆碱酯酶; 血浆D-二聚体
Keywords:
portal hypertension gastropathy; TCM patterns; CHE; D-D
分类号:
R573
DOI:
10.12174/j.issn.2096-9600.2022.04.28
文献标志码:
B
摘要:
目的探讨肝硬化门静脉高压性胃病（portal hypertension gastropathy，PHG）病情程度与中医证型、血小板计数（platelet count，PLT）、胆碱酯酶（cholinesterase，CHE）、血浆D-二聚体（plasma d-dimer，D-D）的相关性。 方法选择确诊为PHG的184例肝硬化患者，每位患者进行Child-Pugh分级及胃镜检查，评估患者病情的轻重程度，将患者的中医辨证分型与病情程度结合，患者的病情程度与PLT、CHE、D-二聚体指标相结合，对不同证型之间与病情程度之间进行分析，对病情程度与PLT、CHE、D-二聚体指标进行分析。 结果184例患者中湿热蕴结证所占比例最大，其次是肝气郁结证、瘀血阻络证、脾肾阳虚证、水湿内阻证、肝肾阴虚证。PHG病情程度与Child-Pugh分级差异有统计学意义（P＜0.05）。PHG病情程度与不同中医证型之间差异有统计学意义（P＜0.05），对PHG不同病情程度中PLT、CHE、D-二聚体进行比较，差异有统计学意义（P＜0.05）。 结论PHG病情程度与不同中医辩证分型、Child-Pugh分级、PLT、CHE、D-二聚体存在相关性，对于临床组方用药、中医辨证论治提供一定的客观依据。
Abstract:
ObjectiveTo discuss the connections between the degree of PHG, TCM patterns, PLT, CHE, D-D. MethodsFor 184 patients with liver cirrhosis diagnosed with PHG, Child-Pugh classification and gastroscopy was performed in each patient, to assess the disease condition of the patients, after combining syndrome differen-tiation and pattern of the patients with the disease conditions, the disease condition and PLT, CHE, D-D, to survey their connections between different patterns and the disease conditions, and the correlations of the disease conditions with PLT, CHE and D-D. ResultsThe proportion of damp-heat accumulation pattern in the observed patients was the biggest, the next liver-qi stagnation pattern, stagnated blood obstructing collateral pattern, spleen-kidney Yang deficiency pattern, water-dampness internal obstruction pattern, liver-kidney yin deficiency pattern. The difference had statistical meaning between disease conditions of PHG and Child-Pugh classification (P<0.05). The difference was statistically significant in the disease conditions of PHG and different TCM patterns (P<0.05), the difference was statistically significant in PLT, CHE and D-D in PHG patients in different disease conditions (P<0.05). ConclusionPHG patients′ states are connected with syndrome differentiation and patterns, Child-Pugh classification, PLT, CHE and D-D, which could be served as the objective evidence for clinical prescription and medication, syndrome differentiation and treatment.

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备注/Memo

备注/Memo:
杜丽明（1986—），女，硕士学位，主治医师。研究方向：脾胃病的中医药诊治。国家自然科学基金应急管理项目（81842041）；河北省中医药管理局科研计划项目（2019265）。
更新日期/Last Update: 2022-06-24