[1]刘真真,钟海森,陶鑫,等.加味过敏煎对荨麻疹抗过敏药效作用的研究[J].西部中医药,2022,35(06):21-24.[doi:10.12174/j.issn.2096-9600.2022.06.06]
　LIU Zhenzhen,ZHONG Haisen,TAO Xin,et al.Study on Antiallergic Effects of Modified Guomin Decoction on Urticaria[J].Western Journal of Traditional Chinese Medicine,2022,35(06):21-24.[doi:10.12174/j.issn.2096-9600.2022.06.06]
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加味过敏煎对荨麻疹抗过敏药效作用的研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年06期
页码:
21-24
栏目:
出版日期:
2022-06-15

文章信息/Info

Title:
Study on Antiallergic Effects of Modified Guomin Decoction on Urticaria
作者:
刘真真, 钟海森, 陶鑫, 卢佩婷, 蒙春伶, 覃骊兰
广西中医药大学，广西 南宁 530001
Author(s):
LIU Zhenzhen, ZHONG Haisen, TAO Xin, LU Peiting, MENG Chunling, QIN Lilan
Guangxi University of Chinese Medicine, Nanning 530001, China
关键词:
荨麻疹; 加味过敏煎; 组胺; 抗过敏; 动物实验
Keywords:
urticaria; modified decoction; histamine; anti-allergy; zoopery
分类号:
R758.24
DOI:
10.12174/j.issn.2096-9600.2022.06.06
文献标志码:
A
摘要:
目的探讨加味过敏煎对荨麻疹小鼠血清组胺含量及组胺所致血管通透性的影响。 方法采用低分子右旋糖酐诱导的小鼠皮肤瘙痒模型，观察小鼠皮肤瘙痒情况，酶联免疫吸附法（ELISA）检测小鼠血清中组胺水平；采用伊文思兰染色法，观察加味过敏煎对组织胺引起的毛细血管通透性增加的影响。 结果与模型组相比，加味过敏煎高剂量组小鼠抓挠潜伏期明显延长，抓挠次数显著减少（P＜0.05），加味过敏煎各剂量组均显著缩短了小鼠的抓挠持续时间（P＜0.05）。ELISA结果显示，加味过敏煎高剂量组能明显减少小鼠血清组胺含量（P＜0.05）。加味过敏煎各剂量组均能减少腹腔内渗出的伊文思蓝染料量，降低OD值（P＜0.05）。 结论加味过敏煎能改善荨麻疹小鼠皮肤瘙痒情况，减少体内组胺含量，降低毛细血管通透性，且高剂量效果最好。
Abstract:
ObjectiveTo discuss the influence of modified Guomin decoction (MGD) on the contents of serum histamine and histamine-induced vascular hyperpermeability in mice with urticaria. MethodsThe mouse skin itching models induced by low molecular dextran were used to observe the skin pruritus of mice, ELISA was adopted to detect the levels of histamine in the serum of the mice; Evans blue staining was used to observe the effects of MGD on histamine-induced vascular hyperpermeability. ResultsCompared with the model group, scratch latency prolonged notably, and scratch times reduced significantly in high dose group of MGD (P<0.05), all dose groups of MGD apparently shortened the scratching duration of mice (P<0.05). ELISA results showed that high dose group of MGD could notably lower the contents of serum histamine in mice (P<0.05). Different doses groups of MGD could reduce the amount of Evans blue dye exuded from abdominal cavity, lower OD values (P<0.05). ConclusionMGD could improve skin itching conditions in mice with urticaria, lower the contents of histamine, reduce capillary permeability, and high dose show the best effects.

相似文献/References:

[1]王康生,李常兴.桂枝汤加减治疗慢性荨麻疹临床观察*[J].西部中医药,2014,27(03):93.
　WANG Kangsheng,LI Changxing.Clinical Observation on Modified GuiZhiTang in Treating Chronic Urticaria[J].Western Journal of Traditional Chinese Medicine,2014,27(06):93.
[2]李墨灵,张晗,夏庆梅△.桂枝汤加减在损容性疾病治疗中的应用[J].西部中医药,2017,30(10):131.
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[3]钟海森,刘真真,覃骊兰,等.从壮医“毒虚论”浅谈荨麻疹的治疗[J].西部中医药,2022,35(07):49.[doi:10.12174/j.issn.2096-9600.2022.07.13]
　ZHONG Haisen,LIU Zhenzhen,QIN Lilan,et al.On the Treatment of Urticaria from ＂Toxin Deficiency Theory＂of Zhuang Medicine[J].Western Journal of Traditional Chinese Medicine,2022,35(06):49.[doi:10.12174/j.issn.2096-9600.2022.07.13]

备注/Memo

备注/Memo:
刘真真（1994—），女，硕士研究生。研究方向：临床中药学。国家自然科学基金（81560755）；广西研究生教育创新计划资助项目（YCSZ20190026）；广西中医药药效研究重点实验室资助项目（19-050-39）。
更新日期/Last Update: 2022-06-24