[1]杨婷婷,李志远,孙小慧,等.基于网络药理学探讨山慈菇治疗乳腺癌的作用机制[J].西部中医药,2022,35(12):44-49.[doi:10.12174/j.issn.2096-9600.2022.12.10]
　YANG Tingting,LI Zhiyuan,SUN Xiaohui,et al.The Mechanism of Shancigu in Treating Breast Cancer on the Basis of Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2022,35(12):44-49.[doi:10.12174/j.issn.2096-9600.2022.12.10]
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基于网络药理学探讨山慈菇治疗乳腺癌的作用机制
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年12期
页码:
44-49
栏目:
出版日期:
2022-12-15

文章信息/Info

Title:
The Mechanism of Shancigu in Treating Breast Cancer on the Basis of Network Pharmacology
作者:
杨婷婷1, 李志远2, 孙小慧2, 杨毅2
1.山东中医药大学，山东 济南 250355
2.山东中医药大学附属医院
Author(s):
YANG Tingting1, LI Zhiyuan2, SUN Xiaohui2, YANG Yi2
1.Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2.Affiliated Hospital to Shandong University of Traditional Chinese Medicine
关键词:
山慈菇; 乳腺癌; 网络药理学; 机制研究
Keywords:
breast cancer; network pharmacology; mechanism study
分类号:
R737.9
DOI:
10.12174/j.issn.2096-9600.2022.12.10
文献标志码:
A
摘要:
目的通过网络药理学方法对山慈菇治疗乳腺癌的作用机制进行探讨。 方法分别运用TCMSP、OMIM、GeneCards数据库挖掘山慈菇及乳腺癌的作用靶点，利用Cytoscape 3.7.2软件构建中药成分-靶点网络，基于STRING数据库进行拓扑分析，筛选出核心靶点，导入Metascape数据库，对药物-疾病交集靶点进行生物通路及富集分析。 结果山慈菇-乳腺癌-靶点网络关系中包含3个有效成分、4个核心靶点、3条生物学通路。 结论山慈菇治疗乳腺癌的作用机制可能为：雌激素、雄激素、孕激素、前列腺素等核心靶点基因，富集在4T1、MDA-MB-231、T-47D等抑制细胞增殖和促凋亡的正调控上；通过上调p53通路、前列腺素干扰血管发育、细胞分化；下调血管内皮生长因子和基质金属蛋白酶-9的表达及Wnt通路活性转录激活过程等来抑制乳腺癌的侵袭转移。
Abstract:
ObjectiveTo discuss the mechanism of Shancigu in treating breast cancer based on network pharmacology. MethodsTCMSP, OMIM and GeneCards databases were used to unearth the targets of Shancigu and breast cancer, Cytoscape3.7.2 software was utilized to construct herbal ingredients-target network, topology analysis was conducted on the foundation of STRING database, to screen out core targets, biological function and enrichment analysis were performed on herb-disease intersection targets after importing the targets into Metascape database. ResultsThe network of Shancigu-breast cancer-targets contained three active ingredients, four core targets and three biological pathways. ConclusionThe mechanism of Shancigu in the treatment of breast cancer is: estrogen, androgen, progesterone, and prostaglandin (PG) and other core target genes are enriched in 4T1, MDA-mb-231, T-47D and other positive regulation of inhibiting cell proliferation and promoting apoptosis; it inhibits the metastasis and invasion of breast cancer by up regulating p53 pathway, PG interfering with vascular development and cell differentiation, and down regulating the expressions of VEGF and MMP-9, and activating Wnt pathway activity and transcription.

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备注/Memo

备注/Memo:
杨婷婷（1994—），女，硕士学位。研究方向：乳腺、甲状腺疾病及疮疡的中西医结合诊治及研究。山东省中医药科技发展计划项目（2019-0160，2019-0090）。
更新日期/Last Update: 2022-12-15