[1]卢健棋,许志亮,朱智德,等.基于网络药理学方法分析稳心颗粒治疗心律失常作用机制[J].西部中医药,2023,36(03):10-18.[doi:10.12174/j.issn.2096-9600.2023.03.03]
　LU Jianqi,XU Zhiliang,ZHU Zhide,et al.The Mechanism of Wenxin Granules in the Treatment of Arrhythmia Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2023,36(03):10-18.[doi:10.12174/j.issn.2096-9600.2023.03.03]
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基于网络药理学方法分析稳心颗粒治疗心律失常作用机制
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年03期
页码:
10-18
栏目:
出版日期:
2023-03-14

文章信息/Info

Title:
The Mechanism of Wenxin Granules in the Treatment of Arrhythmia Based on Network Pharmacology
作者:
卢健棋1, 许志亮2, 朱智德2, 温志浩1, 王庆高1, 潘朝锌1, 庞延1, 林浩2
1.广西中医药大学，广西 南宁 530000
2.广西中医药大学第一附属医院，广西 南宁 530001
Author(s):
LU Jianqi1, XU Zhiliang2, ZHU Zhide2, WEN Zhihao1, WANG Qinggao1, PAN Chaoxin1, PANG Yan1, LIN Hao2
1.Guangxi University of Chinese Medicine, Nanning 530000, China
2.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530001, China
关键词:
心律失常; 网络药理学; 稳心颗粒; 机制
Keywords:
arrhythmia; network pharmacology; granules; mechanism
分类号:
R256.22
DOI:
10.12174/j.issn.2096-9600.2023.03.03
文献标志码:
A
摘要:
目的运用网络药理学方法探讨稳心颗粒治疗心律失常的作用靶点及通路。 方法对收集到的稳心颗粒相关蛋白靶点和心律失常相关基因靶点进行hub基因筛选、基因本体论功能富集分析（gene ontology，GO）和KEGG富集分析（kyoto encyclopedia of genes and genomes，KEGG）。 结果排名前10的基因分别是血管内皮生长因子A(vascular endothelial growth factor A，VEGFA)、丝氨酸/苏氨酸特异性蛋白激酶1（serine/threonine kinase 1,Akt1)、TP53基因(tumor protein P53，TP53)、Jun proto-oncogene（JUN）、白细胞介素6(interleukin-6，IL-6)等。GO富集显示199个生物过程、44个分子功能、29个细胞成分，涉及保护离子通道、抗氧化及抗炎等方面。KEGG通路显示95条通路，其中31条通路与冠心病相关，分别是PI3K-Akt信号通路、HIF-1信号通路、FoxO信号通路、Thyroid hormone信号通路等。 结论稳心颗粒治疗心律失常具有多成分、多靶点的特点，可能通过保护离子通道、抗氧化及保护心肌细胞等发挥作用。
Abstract:
ObjectiveTo explore the targets and pathways of Wenxin granules in the treatment of arrhythmia by using network pharmacology method. MethodsThe relevant protein targets and arrhythmia related gene targets were collected to conduct hub gene screening, GO and KEGG. ResultsThe top ten genes were VEGFA, Akt1, TP53 gene, JUN, IL-6 and others respectively. GO enrichment analysis showed 199 biological processes, 44 molecular functions, 29 molecular ingredients, involving protecting ion channels, antioxidant and anti-inflammatory aspects. KEGG pathways indicated that there were 95 pathways, among them, 31 pathways were related to CHD, and they were PI3k/Akt signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, and thyroid hormone signaling pathway respectively. ConclusionWenxin granules have the characteristics of multi-component and multi-target in the treatment of arrhythmia, and it could develop the effects possibly through protecting ion channels, antioxidant and protecting myocardial cells.

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备注/Memo

备注/Memo:
卢健棋（1963—），男，博士研究生导师，主任医师，教授。研究方向：心血管疾病的中西医结合防治。国家自然科学基金（81560760，81673891）；广西壮族自治区中管局基金（GZZJ16-03）；国家中医临床研究基地业务建设第二批科研专项（JDZX2015146，依托基地：山东省中医院，基地编号：2015C01）；广西壮族自治区卫生计生委计划课题（S2015-32）；广西名老中医工作室建设项目。
更新日期/Last Update: 2023-03-15