[1]杨丽娟,莫婷,何婷,等.消痤乳膏制剂工艺及初步质量评价研究[J].西部中医药,2024,37(09):35-41.[doi:10.12174/j.issn.2096-9600.2024.09.08]
　YANG Lijuan,MO Ting,HE Ting,et al.Study on Preparation Technology and Preliminary Quality Evaluation of Acne-eliminating Cream[J].Western Journal of Traditional Chinese Medicine,2024,37(09):35-41.[doi:10.12174/j.issn.2096-9600.2024.09.08]
点击复制

消痤乳膏制剂工艺及初步质量评价研究
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年09期
页码:
35-41
栏目:
质量分析
出版日期:
2024-09-15

文章信息/Info

Title:
Study on Preparation Technology and Preliminary Quality Evaluation of Acne-eliminating Cream
作者:
杨丽娟1, 莫婷1, 何婷1, 杨森1, 徐静1, 马力2
1.宁夏回族医药研究所，宁夏 银川 750021
2.宁夏中医医院暨中医研究院，宁夏 银川 750021
Author(s):
YANG Lijuan1, MO Ting1, HE Ting1, YANG Sen1, XU Jing1, MA Li2
1.Ningxia Hui Medicine Research Institute, Yinchuan 750021, China
2.Ningxia Chinese Medicine Research Center, Yinchuan 750021, China
关键词:
痤疮; 乳膏; 处方工艺; 质量评价
Keywords:
acne; cream; prescription technology; quality evaluation
分类号:
R284.1
DOI:
10.12174/j.issn.2096-9600.2024.09.08
文献标志码:
A
摘要:
目的优选消痤乳膏的处方工艺并对其进行初步质量评价。 方法根据消痤方中药物的特点及乳膏基质的特点，筛选处方组成，研究制备工艺，考察乳膏的外观性状肤感和离心、高低温稳定性等指标，筛选最佳处方组成，制备消痤乳膏，进行初步质量评价。 结果优选制剂工艺为：油相中加入乳化剂2 g M68，3 g A165，水相中加入0.15 g卡波姆U20，于85 ℃将水相缓慢加入油相中，用乳化均质机25 000 r/min均质5 min，边均质边加入中药提取物粉末，40～50 ℃时加入0.5 g305乳化剂、祛痘复方精油和多元醇抗菌剂即得100 g乳膏。制得乳膏pH为5.5～6.5，粒度＜50 μm；乳膏中芍药苷、黄芩苷、盐酸小檗碱、丹皮酚在各自线性范围内与峰面积呈良好的线性关系，平均加样回收率分别为：100.13%（RSD=2.19%）、99.59%（RSD=1.98%）、98.62%（RSD=2.17%）、101.72%（RSD=2.41%）。 结论制得的消痤乳膏，重现性好，乳膏色泽较纯正，均匀细腻，稠度适宜，易涂布、稳定性好，该工艺可作为最佳配比制备消痤乳膏。
Abstract:
ObjectiveTo optimize the preparation technology of acne-eliminating cream (Xiaocuo Rugao) and to conduct preliminary quality evalution. MethodsAccording to the characteristics of acne-eliminating prescription and cream matrix, the best prescription composition was established by screening the composition, studying the preparation process, and investigating the appearance, property, feeling, centrifugation, high and low temperature stability, thus preparing the cream, meanwhile, the preliminary quality evaluation was carried out. ResultsThe optimized preparation process is as follows: adding 2 g M68 and 3 g A165 emulsifiers to the oil phase, adding 0.15 g carbomer U20 to the water phase, slowly adding the water phase to the oil phase at 85 ℃, homo-genizing for 5 minutes with an emulsifier homogenizer at 25 000 r/min, and adding traditional Chinese medicine extract powder while homogenizing, At 40-50 ℃, mixing 0.5 g 305 emulsifier, acne reducing compound essential oil, and polyol antibacterial agent to obtain 100 g cream. The prepared cream has a pH of 5.5 to 6.5 and the particle size of <50 μm; baicalin, baicalin, berberine hydrochloride and paeonol in cream showed the good linear rela-tionship within peak area and their respective linear ranges, and their average recovery rates were 100.13% (RSD=2.19%), 99.59% (RSD=1.98%), 98.62% (RSD=2.17%), and 101.72% (RSD=2.41%). ConclusionThe prepared cream represents good reproducibility, pure color, fine uniformity, appropriate consistency, easy coating and good stability, and the process could be used as the optimal preparation of the cream.

相似文献/References:

[1]尚亚婷,指导：孙其斌.耳穴放血、贴压及面部拔罐治疗痤疮30例临床观察[J].西部中医药,2013,26(05):114.
　SHANG Yating,Director: SUN Qibin.Clinical Observation on Treatment for 30 Cases of Acne with Ear Acupoint Bloodletting, Pressing and Facial Cupping[J].Western Journal of Traditional Chinese Medicine,2013,26(09):114.
[2]刘君奇.针刺、拔罐联合耳穴贴压治疗痤疮68例临床观察[J].西部中医药,2012,25(07):81.
　LIU Jun-qi.Clinical Observation on Acupuncture and Cupping Combined with Auricular Plaster Therapy in Treating 68 Cases of Acnes[J].Western Journal of Traditional Chinese Medicine,2012,25(09):81.
[3]鄢卫东.痤疮辨治刍议[J].西部中医药,2012,25(05):62.
　YAN Wei-dong.On Experience of Syndrome Differentiation of Acne[J].Western Journal of Traditional Chinese Medicine,2012,25(09):62.
[4]周荣,彭琪,张敏.胃苓汤治疗痤疮53例[J].西部中医药,2014,27(04):98.
　ZHOU Rong,PENG Qi,ZHANG Min.WeiLing Tang in Treating 53 Cases of Acne[J].Western Journal of Traditional Chinese Medicine,2014,27(09):98.
[5]李强强,赵统秀,张晓国,等.白虎消痤汤加减治疗湿热蕴结型痤疮47例[J].西部中医药,2014,27(06):91.
　LI Qiangqiang,ZHAO Tongxiu,ZHANG Xiaoguo Director: ZHANG Dinghua.Modified BaiHu XiaoCuo Tang in Treating 47 Patients with Acne of Damp-heat Accumulation Pattern[J].Western Journal of Traditional Chinese Medicine,2014,27(09):91.
[6]马景和,张海玉,指导：潘星宇.潘星宇辨治痤疮经验辑要[J].西部中医药,2014,27(07):25.
　MA Jinghe,ZHANG Haiyu Director: PAN Xingyu.Pan Xingyu′s Experience of Syndrome Differentiation and Treatment for Acne[J].Western Journal of Traditional Chinese Medicine,2014,27(09):25.
[7]石云.痤疮患者焦虑状态与中医体质类型的相关性研究[J].西部中医药,2015,28(05):87.
[8]林峥嵘,周 文,游世芬,等.刺血加穴位注射治疗痤疮临床观察[J].西部中医药,2016,29(03):102.
　LIN Zhengrong,ZHOU Wen,YOU Shifeng,et al.Clinical Observation on Pricking Blood and Acupoint Injection in Treating Acne[J].Western Journal of Traditional Chinese Medicine,2016,29(09):102.
[9]杨伟丽,刘青△.芦荟多糖乳膏的制备及其性能研究[J].西部中医药,2016,29(01):44.
　YANG Weili,LIU Qing.Study on Preparation and Properties of Aloe Polysaccharide Cream[J].Western Journal of Traditional Chinese Medicine,2016,29(09):44.
[10]安维新,张正华.中药茶饮结合耳穴治疗中学生痤疮120例疗效观察[J].西部中医药,2016,29(05):101.
　AN Weixin,ZHANG Zhenghua.Curative Observation on Herbal Tea Combined with Ear Acupoint in Treating 120 Middle School Students with Acne[J].Western Journal of Traditional Chinese Medicine,2016,29(09):101.

备注/Memo

备注/Memo:
杨丽娟（1982—），女，硕士学位，副主任药师。研究方向：中药与民族药研究。E-mail：66595335@qq.com。宁夏自然科学基金（2019AAC03262）。
更新日期/Last Update: 2024-09-15