夏枯草提取物对糖脂代谢异常大鼠的影响-《西部中医药》

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Title:: Effects of the Extracts of Xiakucao on Abnormal Glucose-lipid Metabolism in Rats

作者:: 李晶, 姚进龙, 刘生肸, 王一强; 甘肃卫生职业学院，甘肃兰州 730207

Author(s):: LI Jing, YAO Jinlong, LIU Shengxi, WANG Yiqiang; Gansu Health Vocational College, Lanzhou730207, China

关键词:: 糖脂代谢异常; 总胆固醇; 甘油三酯; 夏枯草; 大鼠

Keywords:: abnormal glucose-lipid metabolism; total cholesterol; triglyceride; rats

分类号:: R259

DOI:: 10.12174/j.issn.2096-9600.2025.01.02

文献标志码:: A

摘要:: 目的探讨夏枯草提取物对糖脂代谢异常大鼠的影响机制。方法按随机数字表法将SPF级Wistar雄性大鼠分为7组，即空白组、模型组、洛伐他汀组、二甲双胍组及夏枯草提取物高、中、低剂量组。常规饲养1周后，空白组继续给予普通饲料饲养，其余6组均给予高糖高脂饲料饲养30天，建立糖脂代谢异常大鼠模型。造模成功后，药物组分别灌胃5.00、2.50、1.25 g/kg的夏枯草提取物浓缩，3.0 mg/kg洛伐他汀溶液，200 mg/kg二甲双胍溶液，空白组和模型组灌胃10 mL/kg蒸馏水，每天1次，连续15天。末次给药24 h、禁食不禁水12 h 后，大鼠腹腔注射2%戊巴比妥钠麻醉。眼眶取血，测定大鼠血糖、糖化血红蛋白水平；股动脉取血，测定血清总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）含量。结果与空白组比较，模型组大鼠体质量、血清TC和TG、空腹血糖、糖化血红蛋白水平升高（P＜0.05）；与模型组比较，洛伐他汀组及夏枯草高、中剂量组大鼠体质量、血清TC和TG含量降低（P＜0.05），洛伐他汀组及夏枯草高、中、低剂量组血清LDL-C含量、血糖、糖化血红蛋白水平降低（P＜0.05），HDL-C含量升高（P＜0.05）；与洛伐他汀组比较，夏枯草低剂量组大鼠体质量、血清TC和TG含量、空腹血糖、糖化血红蛋白含量升高（P＜0.05）。结论夏枯草提取物能有效调节和控制糖脂代谢异常大鼠体质量、血脂和血糖水平，且夏枯草高、中剂量组对糖脂代谢异常大鼠的调节作用更明显。

Abstract:: ObjectiveTo discuss the effects of the extracts of Xiakucao (Prunellae spica) on rats with abnormal glucose-lipid metabolism. MethodsSPF-grade Wistar male rats were divided into seven groups according to random number table method, that is, the blank group, the model group, lovastatin group, metformin group, high, moderate and low doses groups of the extracts of Xiakucao, after one week of routine feeding, the blank group was given conventional feeding, and the remaining six groups accepted high-sugar, high-fat diet for 30 days, to prepare the rat models with abnormal glucose-lipid metabolism. After successfully modeling, the medicine groups were drenched with 5.00, 2.50 and 1.25 g/kg of the extract concentrate of Xiakucao, 3.0 mg/kg of lovastatin and 200 mg/kg of metformin respectively, the blank group and the model group were given 10 mL/kg of distilled water by gavage, once each day, for 15 days in a row. Rats were anaesthetised with 2% pentobarbital sodium by intraperitoneal injection 24 h after the last dose and 12 h after fasting. The levels of blood glucose and glycated haemoglobin were detected after orbital blood sampling; femoral artery blood collection was adopted to measure the contents of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in the serum. ResultsCompared with the blank group, body mass, the levels of TC and TG, fasting blood glucose (FBG) and glycated haemoglobin were increased in the model group (P<0.05); compared with the model group, body mass, the contents of serum TC and TG were reduced in lovastatin group, high and moderate doses groups of the extracts of Xiakucao (P<0.05), the contents of serum LDL-C, blood glucose and glycated haemoglobin were lowered in lovastatin group, high, moderate and low doses groups of the extracts of Xiakucao (P<0.05), the contents of HDL-C were elevated (P<0.05); compared with lovastatin group, the increase in body mass, the contents of serum TC and TG, FBG and glycated haemoglobin could be seen in low dose group of Xiakucao (P<0.05). ConclusionThe extract of Xiakucao could effectively regulate and control body mass, blood lipid and blood glucose in rats with abnormal glucose-lipid metabolism, and the regulatory effects of high and moderate doses groups of the extracts of Xiakucao on the rats were more significant.

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

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