[1]仪凡,王晓旭,赵子慧,等.基于数据挖掘的银屑病伴焦虑抑郁状态的用药规律探究[J].西部中医药,2025,38(04):41-46.[doi:10.12174/j.issn.2096-9600.2025.04.09]
　YI Fan,WANG Xiaoxu,ZHAO Zihui,et al.Data Mining-based Discussion on the Medication Rules of Psoriasis with Anxiety and Depression[J].Western Journal of Traditional Chinese Medicine,2025,38(04):41-46.[doi:10.12174/j.issn.2096-9600.2025.04.09]
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基于数据挖掘的银屑病伴焦虑抑郁状态的用药规律探究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年04期
页码:
41-46
栏目:
二次研究
出版日期:
2025-04-15

文章信息/Info

Title:
Data Mining-based Discussion on the Medication Rules of Psoriasis with Anxiety and Depression
作者:
仪凡1,2, 王晓旭3, 赵子慧3, 金琦3, 张广中3
1.山东中医药大学附属医院，山东 济南 250014
2.山东中医药大学第一临床医学院，山东 济南 250014
3.首都医科大学附属北京中医医院，北京 100010
Author(s):
YI Fan1,2, WANG Xiaoxu3, ZHAO Zihui3, JIN Qi3, ZHANG Guangzhong3
1.Affiliated Hospital to Shandong University of Traditional Chinese Medicine, Jinan 250014, China
2.First Clinical Medical School, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
3.Beijing Hospital of TCM Affiliated to C
关键词:
银屑病; 焦虑抑郁状态; 数据挖掘; 关联分析; 用药规律
Keywords:
psoriasis; anxiety and depression; data mining; association rules; medication rules
分类号:
R758.63
DOI:
10.12174/j.issn.2096-9600.2025.04.09
文献标志码:
A
摘要:
目的利用数据挖掘技术探究中药治疗银屑病伴焦虑抑郁状态的用药规律，为银屑病伴焦虑抑郁状态的临床治疗提供一定参考。 方法以中国知网、万方、维普数据库收录的文献为资料来源，使用Excel 2019、SPSS Modeler 18.0、SPSS Statistics 20.0等软件对符合纳入标准的中药复方进行频次统计、关联规则分析、系统聚类分析等。 结果共纳入方剂60首，包含药物120味，药性以寒、温、平多见，药味以苦、甘、辛为主，多归肝、肺经；高频中药前10位为生地黄、柴胡、甘草、当归、牡丹皮、土茯苓、紫草、白芍、白鲜皮、黄芩，功效类型主要为清热药和补虚药；关联分析显示常见配伍为生地黄-党参、柴胡-栀子、柴胡-郁金、生地黄-丹皮-柴胡、柴胡-党参-生地黄、黄芩-栀子-柴胡；聚类分析发现从血论治银屑病药物分为3类聚类效果较好。 结论中药论治银屑病伴焦虑抑郁状态以清热凉血、疏肝解郁、养血解毒为治疗大法，初步明确了中药论治银屑病伴焦虑抑郁状态的用药规律，为临床用药及新处方研发提供了一定参考依据。
Abstract:
ObjectiveTo explore the medication rules of traditional Chinese medicine in the treatment of psoriasis with anxiety and depression using data mining technology, so as to provider certain reference for clinical therapy of the disease. MethodsCNKI, Wanfang and VIP were chosen as the source of the data, Excel 2019, SPSS Modeler 18.0 and SPSS Statistics 20.0 and other softwares were applied to perform frequency statistics, association rule analysis and system clustering analysis of herbal compounds that met the inclusion criteria. ResultsSixty prescriptions were included, containing 120 herbs, mostly of cold, warm and neutral nature, with the flavors of mainly bitter, sweet and pungent, and most entering the meridians of liver and lung. The top ten high-frequency herbs were Dihuang(Rehmanniae radix), Chaihu (Bupleuri Radix), and Gancao(Glycyrrhizae radix et rhizoma), Danggui (Angelicae sinensis radix), Mudanpi (Moutan cortex), Tufuling (Smilacis glabrae rhizoma), Zicao (Arnebiae radix), Baishao (Paeoniae radix alba), Baixianpi(Dictamni cortex), and Huangqin (Scutellariae radix) , and they were the ones of clearing heat and tonifying; the analysis of association rules displayed that the common combinations were Dihuang-Dangshen (Codonopsis radix), Chaihu-Zhizi (Gardeniae fructus), Chaihu-Yujin(Curcumae radix), Dihuang-Mudanpi-Chaihu, Chaihu-Dangshen-Dihuang, and Huangqin-Zhizi-Chaihu; cluster analysis displayed that the drugs for treating psoriasis from blood were divided into three categories and the results had good clustering effects. ConclusionThe treatment for psoriasis with anxiety and depression mainly adopts clearing heat and cooling blood, soothing liver for relieving Qi stagnation, nourishing blood and detoxification as the therapeutic methods, and the study has primarily surveyed the medication rules of the treatment, which could provide certain reference for clinical application of herbs and research & development of new prescriptions.

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备注/Memo

备注/Memo:
仪凡（1994—），女，博士学位，主治医师。研究方向：中医药防治皮肤病。甘肃省自然科学基金（21JR1RA054）；甘肃省科技计划项目（18JR2FA001）；省级区域中医（专项）诊疗项目——肿瘤多学科诊疗中心。 国家自然科学基金（81974572，82274523）。
更新日期/Last Update: 2025-04-15