[1]周婷,侯怀晶,张杰,等.甘草防治全麻气管插管相关呼吸道并发症临床疗效Meta分析[J].西部中医药,2025,38(04):89-94.[doi:10.12174/j.issn.2096-9600.2025.04.17]
　ZHOU Ting,HOU Huaijing,ZHANG Jie,et al.Therapeutic Effects of Licorice in the Preventing and Treating Respiratory Complication in Patients with Tracheal Intubation under General Anesthesia:A Meta Analysis[J].Western Journal of Traditional Chinese Medicine,2025,38(04):89-94.[doi:10.12174/j.issn.2096-9600.2025.04.17]
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甘草防治全麻气管插管相关呼吸道并发症临床疗效Meta分析()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年04期
页码:
89-94
栏目:
二次研究
出版日期:
2025-04-15

文章信息/Info

Title:
Therapeutic Effects of Licorice in the Preventing and Treating Respiratory Complication in Patients with Tracheal Intubation under General Anesthesia:A Meta Analysis
作者:
周婷1, 侯怀晶2, 张杰2, 张笑佳2, 崔一阳2, 张斌森2, 薛建军2
1.荆门市人民医院，湖北 荆门 448000
2.甘肃省中医院，甘肃 兰州 730050
Author(s):
ZHOU Ting1, HOU Huaijing2, ZHANG Jie2, ZHANG Xiaojia2, CUI Yiyang2, ZHANG Binsen2, XUE Jianjun2
1.Jingmen People’s Hospital, Jingmen 448000, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
甘草; 全身麻醉; 气管插管; 呼吸道; 并发症; Meta分析
Keywords:
licorice; general anesthesia; tracheal intubation; respiratory tract; complications; Meta analysis
分类号:
R285
DOI:
10.12174/j.issn.2096-9600.2025.04.17
文献标志码:
A
摘要:
目的系统评价甘草用于防治全麻气管插管相关呼吸道并发症的疗效。 方法计算机检索PubMed、The Cochrane Library、Web of Science、EMbase、中国生物医学文献数据库（CBM）、中国知网（CNKI）、维普（VIP）、万方数据库，检索从建库至2022年4月符合纳入标准的随机对照研究。由两名评价者分别进行文献筛选和资料提取，并对所纳入文献进行偏倚风险评价。采用Revman 5.3软件和Stata 17.0软件进行Meta分析。 结果共纳入11篇研究，1122名患者。术后静息和吞咽状态下，甘草组的咽痛发生率显著低于对照组（RR=0.46，95%CI：0.39～0.54，P＜0.05）；RR=0.40，95%CI：0.33～0.49，P＜0.05）；术后静息状态下，甘草组咽痛评分显著低于对照组（SMD=-1.21，95%CI：-1.50～-0.92，P＜0.05）；甘草组拔管后咳嗽的发生率显著低于对照组（RR=0.56，95%CI：0.48～0.64，P＜0.05）；两组术后声嘶的发生率差异无统计学意义（RR=0.48，95%CI：0.12～1.96，P=0.31）。Begg?s检验（Z=0.89，P=0.37）显示无明显发表偏倚。 结论与对照组相比，术前口咽部局部应用甘草制剂可减少术后咽痛和拔管后咳嗽的发生率，并可降低咽痛评分，有效地防治全麻气管插管相关呼吸道并发症。
Abstract:
ObjectiveTo systematically assess clinical effects of licorice (Glycyrrhizae radix et rhizoma) in the prevention and treatment of respiratory complication in patients with tracheal intubation under general anesthesia. MethodsRandomized controlled trials that met the inclusion criteria were retrieved from the time of database establishment to April, 2022 by searching PubMed, The Cochrane Library, Web of Science, EMbase and CBM, CNKI, VIP and Wanfang database via computer. Literature screening and data extraction were carried out by two researchers respectively, and the risk of bias was evaluated for the included literature. Revman 5.3 software and Stata 17.0 software were applied to perform Meta analysis. ResultsThe study has included 11 studies and 1122 patients. Under rest conditions after the operation or when the patients were swallowing, the incidence of pharyngalgia of licorice group was evidently lower than that of the control group (RR=0.46, 95%CI:0.39 - 0.54, P<0.05); (RR=0.40, 95%CI:0.33 - 0.49, P<0.05); when the patients were at rest after the surgery, the scores of pharyngalgia in licorice group were lower than these in the control group (SMD=-1.21, 95%CI:-1.50 - -0.92, P<0.05); the incidences of postextubation coughing (PEC) in licorice group were lower than these in the control group apparently (RR=0.56, 95%CI:0.48 - 0.64, P<0.05); the difference had no statistical meaning in the incidences of postoperative cerchnus between both groups (RR=0.48, 95%CI:0.12 - 1.96, P=0.31). Begg’s test (Z=0.89, P=0.37) showed no significant publication bias. ConclusionCompared with the control group, preoperative topical applica-tion of licorice preparation to the oropharynx could reduce the incidence rates of postoperative pharyngalgia and PEC, decrease the scores of pharyngalgia, and effectively prevent and treat respiratory complication related to general anesthesia tracheal intubation.

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备注/Memo

备注/Memo:
周婷（1989—），女，硕士学位，主治医师。研究方向：临床麻醉与术后疼痛。兰州市人才创新创业项目（2018-RC-93）。
更新日期/Last Update: 2025-04-15