[1]程汝珍,倪道艳,张伟,等.中药调控细胞死亡防治阿尔茨海默病机制研究进展[J].西部中医药,2025,38(06):117-121.[doi:10.12174/j.issn.2096-9600.2025.06.22]
　CHENG Ruzhen,NI Daoyan,ZHANG Wei,et al.Research Progress in the Mechanism of Preventing and Treating Alzheimer?s Disease with Herbs via the Regulation of Cell Death[J].Western Journal of Traditional Chinese Medicine,2025,38(06):117-121.[doi:10.12174/j.issn.2096-9600.2025.06.22]
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中药调控细胞死亡防治阿尔茨海默病机制研究进展()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年06期
页码:
117-121
栏目:
研究进展
出版日期:
2025-06-15

文章信息/Info

Title:
Research Progress in the Mechanism of Preventing and Treating Alzheimer?s Disease with Herbs via the Regulation of Cell Death
作者:
程汝珍1, 倪道艳2, 张伟1, 王凯2
1.天津中医药大学，天津 300193
2.天津中医药大学第二附属医院，天津 300150
Author(s):
CHENG Ruzhen1, NI Daoyan2, ZHANG Wei1, WANG Kai2
关键词:
阿尔茨海默病; 细胞死亡; 自噬; 程序性坏死; 综述
Keywords:
Alzheimer’s disease; cell death; autophagy; programmed necrosis; review
分类号:
R256.29
DOI:
10.12174/j.issn.2096-9600.2025.06.22
文献标志码:
A
摘要:
对中药调控细胞死亡防治阿尔茨海默病（Alzheimer?s disease，AD）的主要作用机制进行综述，指出细胞死亡受多种因素调节，包括凋亡、自噬、程序性坏死和焦亡等。中药主要通过外源性和内源性信号途径调节细胞凋亡，通过雷帕霉素靶蛋白（mammalian target of rapamycin，mTOR）和非mTOR途径双向调节自噬，并通过抑制RIPK1-RIPK3-MLKL信号通路，减轻程序性坏死，保护神经元；中药还能通过半胱天冬氨酸蛋白酶1（cysteinyl aspartate specific proteinase 1，Caspase-1）激活的经典途径和Caspase-4、Caspase-5、Caspase-11激活的非经典途径抑制细胞焦亡，减轻炎症反应，从而发挥改善AD认知功能的作用。
Abstract:
By reviewing the mechanism of the prevention and regulation of Alzheimer’s disease (AD) with herbs via regulating cell death, cell death is regulated by a variety of factors, including apoptosis, autophagy, programmed necrosis and pyroptosis. Materia medica could regulate cellular apoptosis mainly by exogenous and endogenous signaling pathways, and bidirectionally adjust autophagy via mTOR and non-mTOR pathways, relieve programmed necrosis and protect the neurons by inhibiting RIPK1-RIPK3-MLKL signaling pathway; meanwhile materia medica could restrain cellular pyroptosis and alleviate inflammatory reaction mainly through Caspase1-activated classical pathway and Caspase-4/5/11-activated non-classical pathway, thereby improving cognitive function in AD.

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备注/Memo

备注/Memo:
程汝珍（1991—），女，在读博士研究生，医师。研究方向：脑血管疾病的中西医结合诊治。国家自然科学基金面上项目（81973797）；国家自然科学基金青年基金项目（82104801）。
更新日期/Last Update: 2025-06-15