[1]郭夏晴,杜娟娇,叶世青,等.中医药调控NF-κB信号通路防治糖尿病足溃疡的研究进展[J].西部中医药,2025,38(06):126-129.[doi:10.12174/j.issn.2096-9600.2025.06.24]
　GUO Xiaqing,DU Juanjiao,YE Shiqing,et al.Advance in TCM Prevention and Treatment of Diabetic Foot Ulcer via NF-κB Signaling Pathway Regulation[J].Western Journal of Traditional Chinese Medicine,2025,38(06):126-129.[doi:10.12174/j.issn.2096-9600.2025.06.24]
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中医药调控NF-κB信号通路防治糖尿病足溃疡的研究进展()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年06期
页码:
126-129
栏目:
研究进展
出版日期:
2025-06-15

文章信息/Info

Title:
Advance in TCM Prevention and Treatment of Diabetic Foot Ulcer via NF-κB Signaling Pathway Regulation
作者:
郭夏晴1, 杜娟娇2, 叶世青1, 王茜茜1, 曹妍1, 陈仲件1
1.广西中医药大学研究生院，广西 南宁 530001
2.广西中医药大学第一附属医院，广西 南宁 530001
Author(s):
GUO Xiaqing1, DU Juanjiao2, YE Shiqing1, WANG Xixi1, CAO Yan1, CHEN Zhongjian1
关键词:
糖尿病足溃疡; 核因子B; 信号通路; 中医药
Keywords:
diabetic foot ulcer; NF-B; signaling pathway; TCM
分类号:
R255.4
DOI:
10.12174/j.issn.2096-9600.2025.06.24
文献标志码:
A
摘要:
对核因子κB（nuclear factor-κB，NF-κB）置信度均大于0.9的信号通路及其与糖尿病足溃疡（diabetic foot ulcer，DFU）的关系作一综述，探讨中药通过NF-κB信号通路防治DFU的研究现状，指出NF-κB信号通路上游受体介导的炎症反应广泛参与DFU的形成及愈合阶段，而中药防治DFU具有多层次、多靶点、多途径优势，其主要通过抑制炎症反应，促进血管新生等防治DFU。
Abstract:
The article summarized the signaling pathway with the confidence level of NF-κB greater than 0.9 and its connection with diabetic foot ulcer (DFU), and surveyed research status of TCM prevention and treatment of DFU via NF-κB signaling pathway. Inflammatory response mediated by upstream receptors of NF-κB signaling pathway has widely participated in the formation of DFU and its healing stage, while TCM therapy, with the advantages of multiple levels, multiple targets and multiple pathways, could prevent DFU mainly through inhibiting inflammatory reaction and promoting angiogenesis.

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备注/Memo

备注/Memo:
郭夏晴（1992—），女，硕士学位，医师。研究方向：烧伤与体表溃疡的中医治疗。国家自然科学基金（81360572）。
更新日期/Last Update: 2025-06-15