[1]李珺,张玮,王高强,等.实脾固肾化瘀方对慢性心肾综合征患者AMPK/SIRT1/NF-κB信号通路的影响[J].西部中医药,2021,34(10):107-110.[doi:10.12174/j.issn.2096-9600.2021.10.26]
　LI Jun,ZHANG Wei,WANG Gaoqiang,et al.Impacts of Spleen-kidney-strengthening Stasis-removing Prescription on AMPK/SIRT1/NF-κB Signaling Pathway in Patients with Chronic Cardiorenal Syndrome[J].Western Journal of Traditional Chinese Medicine,2021,34(10):107-110.[doi:10.12174/j.issn.2096-9600.2021.10.26]
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实脾固肾化瘀方对慢性心肾综合征患者AMPK/SIRT1/NF-κB信号通路的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年10期
页码:
107-110
栏目:
出版日期:
2021-10-15

文章信息/Info

Title:
Impacts of Spleen-kidney-strengthening Stasis-removing Prescription on AMPK/SIRT1/NF-κB Signaling Pathway in Patients with Chronic Cardiorenal Syndrome
作者:
李珺, 张玮, 王高强, 岳艳利, 杨盼, 刘涵荫, 沈丽萍
上海市杨浦区中医医院，上海 200090
Author(s):
LI Jun, ZHANG Wei, WANG Gaoqiang, YUE Yanli, YANG Pan, LIU Hanyin, SHEN Liping
Shanghai City Yangpu District Hospital of TCM, Shanghai 200090, China
关键词:
心肾综合征; 慢性; 实脾固肾化瘀方; 核因子B; 信号通路; 炎症
Keywords:
cardiorenal syndrome;  chronic; spleen-kidney-strengthening stasis-removing prescription; NF-B; signaling pathway; inflammation
分类号:
R714.14+4
DOI:
10.12174/j.issn.2096-9600.2021.10.26
摘要:
目的探讨实脾固肾化瘀方治疗慢性心肾综合征的疗效及其对AMP活化蛋白激酶（AMP-activated protein kinase，AMPK）/沉默调节蛋白1（silencing regulator 1，SIRT1）/核因子κB（nuclear factor κB，NF-κB）信号通路的影响。 方法选择慢性心肾综合征患者96例，根据随机数字法分为观察组和对照组，每组48例。对照组予以常规治疗，观察组在对照组的基础上予以实脾固肾化瘀方治疗。观察两组治疗后的疗效，治疗前后内生肌酐清除率（creatinine clearance，Ccr）、24 h尿蛋白、尿白蛋白排泄率（urinary albumin excretion rate，UAER）、胱抑素C（cystatin C，CysC）、NT-proBNP、左室射血分数（left ventricular ejection fraction，LVEF）、左室收缩末期内径（left ventricular end-systolic diameter，LVESD）、左室舒张末期内径（left ventricular end-diastolic diameter，LVEDD）、肾脏动脉内径（renal artery diameter，D）、肾血流量（renal blood flow volume，V）、阻力指数（resistance index，RI），AMPK，SIRT1和NF-κB水平的变化。 结果治疗后观察组总有效率［85.42%（41/48）］明显高于对照组［64.58%（31/48）］（P＜0.05）；治疗后两组Ccr、D、V、AMPK及SIRT1较治疗前明显升高（P＜0.01），而24 h尿蛋白、UAER、CysC、RI及NF-κB水平较治疗前明显降低（P＜0.01），观察组改善水平较对照组更明显（P＜0.01）。 结论实脾固肾化瘀方治疗慢性心肾综合征疗效显著，能够改善心肾功能，增加肾脏血流量，抑制机体的炎症，其机制与抑制AMPK/SIRT1/NF-κB信号通路有关。
Abstract:
ObjectiveTo discuss clinical effects of spleen-kidney-strengthening stasis-removing prescription in treating chronic cardiorenal syndrome and its influence on AMPK/SIRT1/NF-κB signaling pathway. MethodsAll 96 patients were chosen, divided into the observation group and the control group according to random number table method, 48 cases in each group. The control group accepted conventional therapy, the observation group took spleen-kidney-strengthening stasis-removing prescription orally on the foundation of conventional therapy. To observe clinical effects after treating of the two groups, Ccr, 24 h urinary protein, UAER, CysC, NT-proBNP, LVEF, LVESD, LVEDD, D, V, RI, the levels of AMPK, SIRT1 and NF-κB before and after treating. ResultsAfter treating, total effective rate of the observation group was [85.42%(41/48)], notably higher than [64.58%(31/48)] (P<0.05); after treating, Ccr, D, V, AMPK and SIRT1 of both groups increased notably than these before treating (P<0.01), while the levels of 24 h urinary protein, UAER, CysC, RI and NF-κB lowered notably than these before treating (P<0.01), the improvements of the observation group were more notable than these of the control group (P<0.01). ConclusionSpleen-kidney-strengthening stasis-removing prescription is effective in treating chronic cardiorenal syndrome, it could improve cardiorenal function, increase renal blood flow, inhibit the inflammation of human body, and its mechanim might be related to inhibiting AMPK/SIRT1/NF-κB signaling pathway.

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备注/Memo

备注/Memo:
李珺（1983—），女，硕士学位，主治医师。研究方向：糖尿病肾病、慢性肾脏病的诊治。上海市杨浦区卫生计生系统“好医师”建设工程项目［ZY（2018-2020）-FWTX-6018］。
更新日期/Last Update: 2021-10-15