[1]朱建坤,温晓辉,梁玉杰△.敦煌葆元膏对下丘脑-垂体-肾上腺轴作用的实验研究*[J].西部中医药,2013,26(11):13-15.
 ZHU Jiankun,WEN Xiaohui,LIANG Yujie.Experimental Study on the Effects of DunHuang BaoYuan Ointment on Hypothalamic-pituitary-adrenal Axis[J].Western Journal of Traditional Chinese Medicine,2013,26(11):13-15.
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敦煌葆元膏对下丘脑-垂体-肾上腺轴作用的实验研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年11期
页码:
13-15
栏目:
出版日期:
2013-11-15

文章信息/Info

Title:
Experimental Study on the Effects of DunHuang BaoYuan Ointment on Hypothalamic-pituitary-adrenal Axis
文章编号:
1004-6852(2013)11-0013-03
作者:
朱建坤温晓辉梁玉杰△
甘肃中医学院,甘肃 兰州730000
Author(s):
ZHU Jiankun, WEN Xiaohui, LIANG Yujie△
Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
关键词:
疲劳综合征慢性下丘脑-垂体-肾上腺轴五羟色胺皮质酮敦煌葆元膏
Keywords:
chronic fatigue syndrome hypothalamic-pituitary-adrenal axis serotonin corticosteroneDunHuang BaoYuan ointment
分类号:
R285.5
文献标志码:
A
摘要:
目的:探讨敦煌葆元膏对慢性疲劳综合征模型大鼠下丘脑-垂体-肾上腺轴的影响,以了解敦煌葆元膏补肾功能的生理基础点。方法:将40只慢性疲劳模型大鼠随机分为高(4.2 g/kg)、中(1.4 g/kg)、低(0.7 g/kg)剂量组及模型对照组各10只,另设空白对照组10只,灌胃1周后大鼠股动脉采血检测血清中促肾上腺皮质激素释放激素(CRH)、五羟色胺(5-HT)以及皮质酮(Cort.)的含量。结果:敦煌葆元膏高、中、低剂量组血清CRH、5-HT以及Cort.含量较高,模型对照组与空白对照组含量较低。结论:敦煌葆元膏可能通过调节HPA中相关激素含量水平,激发其生理功能,从而发挥补肾的药理作用。
Abstract:
Objective: To explore the effects of DunHuang BaoYuan ointment on hypothalamic-pituitary-adrenal axis of the rats with chronic fatigue syndrome and know physiological basic points for kidney-nourishing of DunHuang BaoYuan ointment. Method: Forty rats were randomized into four groups: high(4.2 g/kg) dosage group, moderate(1.4g/kg) dosage group, low(0.7g/kg) dosage group and model control group. Another ten rats were established as blank control group. After lavage for one week, the contents of corticosterone(Cort.), serotonin (5-HT) and corticotrophin releasing hormone(CRH) were detected in the serum of femoral blood. Result: The contents of CRH, 5-HT and Cort. were higher in the groups of high dosage, moderate dosage and low dosage. The contents of the indexes in model control group and blank control group were lower. Conclusion: DunHuang BaoYuan ointment could play the function of kidney-nourishing by regulating associated hormone level in PHA that motivates its physiological function.

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备注/Memo

备注/Memo:
收稿日期:2013-04-01 *基金项目:兰州市科技计划项目(编号BH2011-106) 作者简介:朱建坤(1970—),男,硕士学位,讲师。研究方向:儿科疾病的中医诊治。 △通讯作者:梁玉杰(1962—),男,教授。研究方向:医史文献。
更新日期/Last Update: 2013-11-15