[1]李闻音,李波,金伶佳,等.基于减毒增效目的探讨复方雷公藤汤最佳制备工艺[J].西部中医药,2025,38(07):1-5.[doi:10.12174/j.issn.2096-9600.2025.07.01]
　LI Wenyin,LI Bo,JIN Lingjia,et al.The Optimum Preparation Process of Compound Leigongteng Decoction Based on Toxicity Reducing and Efficacy Enhancing[J].Western Journal of Traditional Chinese Medicine,2025,38(07):1-5.[doi:10.12174/j.issn.2096-9600.2025.07.01]
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基于减毒增效目的探讨复方雷公藤汤最佳制备工艺()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年07期
页码:
1-5
栏目:
质量分析
出版日期:
2025-07-15

文章信息/Info

Title:
The Optimum Preparation Process of Compound Leigongteng Decoction Based on Toxicity Reducing and Efficacy Enhancing
作者:
李闻音1, 李波2, 金伶佳3, 吴美兰4
1.辽宁中医药大学中医学院，辽宁 沈阳 110847
2.大连市皮肤病医院，辽宁 大连 116021
3.大连市中心医院，辽宁 大连 116033
4.大连市中医医院，辽宁 大连 116013
Author(s):
LI Wenyin1, LI Bo2, JIN Lingjia3, WU Meilan4
1.College of TCM, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China
2.Dalian Dermatosis Hospital, Dalian 116021, China
3.Dalian Central Hospital, Dalian 116033, China
4.Dalian Hospital of Traditional Chinese Medicine, Dalian 116013, China
关键词:
复方雷公藤汤; 制备工艺; 正交设计; 肾病大鼠; 肝脏; 实验研究
Keywords:
compound decoction; preparation process; the orthogonal design; nephrotic rats; liver; experimental study
分类号:
R945
DOI:
10.12174/j.issn.2096-9600.2025.07.01
文献标志码:
A
摘要:
目的探究复方雷公藤汤最佳制备工艺的正交设计对肾病大鼠肝脏的减毒增效作用。 方法复制肾病模型后，将肾病模型大鼠随机分为9组，每组10只，均连续灌服不同制备工艺的复方雷公藤汤20日。测量大鼠24 h尿蛋白定量、谷丙转氨酶、谷草转氨酶。筛选出复方雷公藤汤最佳制备工艺组合。 结果影响肝脏毒性因素大小的排序为雷公藤先煎时间＞煎煮时间＞浸泡时间＞加水量；影响24 h尿蛋白定量因素大小的排序为雷公藤先煎时间＞煎煮时间＞加水量＞浸泡时间，浸泡时间无影响。 结论复方雷公藤汤治疗肾病以减低肝脏毒性为主，采用A3B2C1D3的煎煮工艺；治疗肾病以降低24 h尿蛋白为主，采用A1B3C3D3的煎煮工艺，两种煎煮工艺均能起到减毒增效作用。
Abstract:
ObjectiveTo explore the toxicity-reducing and efficacy-enhancing effects of the orthogonal design of the optimum preparation process of compound Leigongteng (Tripterygium wilfordii Hook. f.) decoction on the liver of nephrotic rats. MethodsAfter replicating the nephropathy models, the model were randomized into nine groups with ten in each, and they were drenched with the decoction prepared by different methods for 20 days continuously. To detect 24-hour urine total protein quantity (24 hUTP), the levels of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase of the rats, and to screen the optimum preparation process of compound Leigongteng decoction. ResultsThe factors influencing hepatotoxicity ranked in the descending order: the time of Leigongteng decocting first>decocting time>soaking time>water addition. The factors influencing 24 hUTP showed in the descending order: the time of Leigongteng decocting first>decocting time>water addition>soaking time, and no influence was found in soaking time. ConclusionWhen compound Leigongteng decoction in the treatment of nephropathy is used to reduce liver toxicity, A3B2C1D3 boiling process is adopted; when it is applied to lower 24hUTP, it’s appropriate to adopt A1B3C3D3 boiling process, the two kinds of processes could reduce the toxicity and enhance clinical effects.

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备注/Memo

备注/Memo:
李闻音（2003—），女，学生。研究方向：中西医治疗皮肤病及中药减毒增效。国家自然科学基金（81250027）。
更新日期/Last Update: 2025-07-15