[1]石沛薷,李凯,汪晶,等.线粒体自噬在缺血性脑卒中中的作用机制及中医药防治研究现状[J].西部中医药,2026,39(02):111-117.[doi:10.12174/j.issn.2096-9600.2026.02.22]
　SHI Peiru,LI Kai,WANG Jing,et al.The Mechanism of Mitophagy in Ischemic Stroke and the Current State of Research on TCM Prevention and Treatment[J].Western Journal of Traditional Chinese Medicine,2026,39(02):111-117.[doi:10.12174/j.issn.2096-9600.2026.02.22]
点击复制

线粒体自噬在缺血性脑卒中中的作用机制及中医药防治研究现状()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年02期
页码:
111-117
栏目:
研究进展
出版日期:
2026-02-15

文章信息/Info

Title:
The Mechanism of Mitophagy in Ischemic Stroke and the Current State of Research on TCM Prevention and Treatment
作者:
石沛薷1, 李凯1, 汪晶1, 郭源1, 张举昭1, 邵亚2, 曹骅2
1.甘肃中医药大学，甘肃 兰州 730000
2.甘肃省中医院，甘肃 兰州 730050
Author(s):
SHI Peiru1, LI Kai1, WANG Jing1, GUO Yuan1, ZHANG Juzhao1, SHAO Ya2, CAO Hua2
1.Gansu University of Chinese Medicine, Lanzhou 730000, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
缺血性脑卒中; 线粒体自噬; 中医药; 研究进展
Keywords:
ischemic stroke; mitophagy; TCM; research progress
分类号:
R255.2
DOI:
10.12174/j.issn.2096-9600.2026.02.22
文献标志码:
A
摘要:
对线粒体自噬在缺血性脑卒中（ischemic stroke，IS）中的作用机制及中医药防治研究现状进行综述，指出线粒体自噬通过清除受损线粒体、减少氧化应激、缓解钙超载、抑制细胞凋亡及炎症反应，在IS的神经保护中发挥重要作用，而中药活性成分如苯酞类、萜类、酚类、醌类、苷类、酮类化合物等能够通过不同机制调节线粒体自噬，改善细胞功能并促进神经修复。
Abstract:
The article reviewed the mechanism of mitophagy in ischemic stroke (IS) and the current state of research on TCM prevention and treatment, it was pointed out that mitophagy played the key role in neural protection of IS through clearing the damaged mitochondria, reducing oxidative stress, relieving calcium overload, alongside inhibiting apoptosis and inflammatory response, and the active ingredients of the herbs such as benzophenones, terpenes, and phenols, quinones, together with glycosides, ketones and others, could adjust mitophagy via different mechanisms, improve cell function and promote nerve repair.

相似文献/References:

[1]令丽梅,王智先,王玲.高同型半胱氨酸血症与缺血性脑卒中的相关性探讨[J].西部中医药,2013,26(12):142.
　LING Limei,WANG Zhixian,WANG Ling.Exploration on the Relativity between Hyperhomocystinemia and Ischemic Stroke[J].Western Journal of Traditional Chinese Medicine,2013,26(02):142.
[2]张黎珍.缺血性脑卒中患者实施早期康复护理效果观察[J].西部中医药,2015,28(01):87.
[3]赵东科,刘志华,吴启元,等.补阳还五汤加减联合通脑活络针刺疗法治疗急性缺血性脑卒中临床观察[J].西部中医药,2025,38(10):127.[doi:10.12174/j.issn.2096-9600.2025.10.22]
　ZHAO Dongke,LIU Zhihua,WU Qiyuan,et al.Clinical Observation on Modified Buyang Huanwu Decoction Combined with Consciousness-restoring Collateral-reinforcing Needling in the Treatment of Acute Ischemic Stroke[J].Western Journal of Traditional Chinese Medicine,2025,38(02):127.[doi:10.12174/j.issn.2096-9600.2025.10.22]
[4]张谦,秦晓光.郑氏“温通针法”对缺血性脑卒中患者肢体功能的影响[J].西部中医药,2022,35(01):124.[doi:10.12174/j.issn.2096-9600.2022.01.30]
　ZHANG Qian,QIN Xiaoguang.Effects of Zheng’s “Warming-dredging Needling” on Limb Function in Patients with Ischemic Stroke[J].Western Journal of Traditional Chinese Medicine,2022,35(02):124.[doi:10.12174/j.issn.2096-9600.2022.01.30]
[5]邓志云,任小巧,赵慧辉.基于藏医不同时辰组合用药治疗隆滞布病（缺血性脑卒中）临床观察[J].西部中医药,2022,35(04):77.[doi:10.12174/j.issn.2096-9600.2022.04.17]
　DENG Zhiyun,REN Xiaoqiao,ZHAO Huihui.Clinical Observation on the Treatment of Longzhibu Disease (Ischemic Stroke) by the Combination of Tibetan Medicine at Different Time[J].Western Journal of Traditional Chinese Medicine,2022,35(02):77.[doi:10.12174/j.issn.2096-9600.2022.04.17]
[6]朱穆朗玛,陈珂,钟兆怡,等.中西医结合分期辨证治疗缺血性脑卒中研究进展[J].西部中医药,2022,35(07):135.[doi:10.12174/j.issn.2096-9600.2022.07.35]
　ZHU Mulangma,CHEN Ke,ZHONG Zhaoyi,et al.Progress in the Treatment of Ischemic Stroke by Stage Differentiation of TCM and Western Medicine[J].Western Journal of Traditional Chinese Medicine,2022,35(02):135.[doi:10.12174/j.issn.2096-9600.2022.07.35]
[7]韦辉燕,徐玉婷,杨丽燕,等.熄风化痰通络汤治疗老年缺血性脑卒中患者临床观察[J].西部中医药,2021,34(04):88.[doi:10.12174/j.issn.2096-9600.2021.04.22]
　WEI Huiyan,XU Yuting,YANG Liyan,et al.Clinical Observation of Xifeng Huatan Tongluo Tang in Treating in the Elderly Patients with Ischemic Stroke[J].Western Journal of Traditional Chinese Medicine,2021,34(02):88.[doi:10.12174/j.issn.2096-9600.2021.04.22]
[8]冯春燕,康煜炜,张春红,等.丘墟透照海对缺血性脑卒中患者足内翻表面肌电RMS Mean值的影响[J].西部中医药,2022,35(11):4.[doi:10.12174/j.issn.2096-9600.2022.11.02]
　FENG Chunyan,KANG Yuwei,ZHANG Chunhong,et al.Penetration Needling on RMS Mean Value of the Surface Myoelectricity of the Foot Varus in Ischemic Stroke[J].Western Journal of Traditional Chinese Medicine,2022,35(02):4.[doi:10.12174/j.issn.2096-9600.2022.11.02]
[9]王春玲,罗宁,文晓东,等.乌梅总黄酮通过线粒体自噬对帕金森病大鼠的保护作用[J].西部中医药,2022,35(12):72.[doi:10.12174/j.issn.2096-9600.2022.12.15]
　WANG Chunling,LUO Ning,WEN Xiaodong,et al.Protective Effects of Fructus Mume Total Flavone on Rat Model with Parkinson’s Disease Through Mitophagy[J].Western Journal of Traditional Chinese Medicine,2022,35(02):72.[doi:10.12174/j.issn.2096-9600.2022.12.15]
[10]莫雨晓,陈楚云,张去飞,等.基于脑功能磁共振成像系统评价针灸治疗缺血性脑卒中的疗效[J].西部中医药,2023,36(05):61.[doi:10.12174/j.issn.2096-9600.2023.05.14]
　MO Yuxiao,CHEN Chuyun,ZHANG Qufei,et al.Systematic Evaluation of Clinical Effects of Acupuncture in the Treatment of Ischemic Stroke Based on Brain Functional Magnetic Resonance Imaging[J].Western Journal of Traditional Chinese Medicine,2023,36(02):61.[doi:10.12174/j.issn.2096-9600.2023.05.14]

备注/Memo

备注/Memo:
甘肃省自然科学基金（20JR10RA355）；国家中医优势专科建设项目（甘卫中医函〔2023〕63号）；甘肃省卫生健康行业科研（GSWSKY2022-27，GSWSHL2023-24）。石沛薷（1999—），女，在读硕士研究生。研究方向：脑血管疾病的中西医结合诊治。
更新日期/Last Update: 2026-02-15