[1]韦辉燕,徐玉婷,杨丽燕,等.熄风化痰通络汤治疗老年缺血性脑卒中患者临床观察[J].西部中医药,2021,34(04):88-92.[doi:10.12174/j.issn.2096-9600.2021.04.22]
　WEI Huiyan,XU Yuting,YANG Liyan,et al.Clinical Observation of Xifeng Huatan Tongluo Tang in Treating in the Elderly Patients with Ischemic Stroke[J].Western Journal of Traditional Chinese Medicine,2021,34(04):88-92.[doi:10.12174/j.issn.2096-9600.2021.04.22]
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熄风化痰通络汤治疗老年缺血性脑卒中患者临床观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年04期
页码:
88-92
栏目:
出版日期:
2021-04-15

文章信息/Info

Title:
Clinical Observation of Xifeng Huatan Tongluo Tang in Treating in the Elderly Patients with Ischemic Stroke
作者:
韦辉燕, 徐玉婷, 杨丽燕, 符文雄
海口市中医医院，海南 海口，570216
Author(s):
WEI Huiyan, XU Yuting, YANG Liyan, FU Wenxiong
Haikou Hospital of Traditional Chinese Medicine, Haikou 570216, China
关键词:
缺血性脑卒中; 老年; 熄风化痰通络汤; 脑源性神经生长因子; 溶血磷脂酸; 神经因子; 高凝状态; 炎症反应; 神经功能
Keywords:
ischemic stroke;  the elderly; BDNF; LPA; nerve growth factor; hypercoagulable state; inflammatory reaction; neurological function
分类号:
R255.2
DOI:
10.12174/j.issn.2096-9600.2021.04.22
摘要:
目的探讨熄风化痰通络汤对老年缺血性脑卒中（风痰瘀阻型）患者血浆溶血磷脂酸（lysophosphatidic acid，LPA）、基质金属蛋白酶9（matrix metalloproteinase-9，MMP-9）、脑源性神经生长因子（brain-derived nerve growth factor，BDNF）水平和临床疗效的影响。 方法选择老年缺血性脑卒中（风痰瘀阻型）患者93例，按照随机数字表法分为观察组（47例）和对照组（46例）。对照组采用单纯缺血性脑卒中常规治疗，观察组联合熄风化痰通络汤口服治疗，治疗2周后比较两组临床疗效。 结果治疗后观察组血清神经元特异性烯醇化酶（neuron specific enolase，NSE）水平及纤维蛋白原（fibrinogen，Fib）低于对照组，BDNF高于对照组（P＜0.05）；治疗后观察组MMP-9、LPA、超敏C反应蛋白（high-sensitive C-reactive protein，hs-CPR）、同型半胱氨酸（homocysteine，Hcy）水平低于对照组（P＜0.05）；治疗后观察组日常生活能力评分（ability of daily living，ADL）高于对照组，神经功能评分（neurological functional score，NIHSS）低于对照组（P＜0.05）；总有效率观察组91.49%（43/47），高于对照组的73.91%（34/46）（P＜0.05）；不良反应总发生率观察组与对照组比较差异无统计学意义（P＞0.05）。 结论熄风化痰通络汤联合西药治疗老年缺血性脑卒中，可有效减轻患者炎症反应，促进神经功能恢复，改善血液高凝状态，且安全性高。
Abstract:
ObjectiveTo discuss the influence of Xifeng Huatan Tongluo Tang (wind phlegm stagnation pattern) on the levels of LPA, MMP-9 and BDNF in the elderly with ischemic stroke and clinical effects. MethodsAll 93 patients were chosen, divided into the observation group (47 cases) and the control group (46 cases) according to random number table method. The control group adopted conventional therapy of single ischemic stroke, and the observation group took Xifeng Huatan Tongluo Tang orally, to compare clinical effects between two groups after treating for two weeks. ResultsAfter treating, the observation group was lower than the control group in the levels of NSE and Fib, higher than the control group in BDNF (P<0.05); after the treatment, the levels of MMP-9, LPA, hs-CRP and Hcy of the observation group were lower than these of the control group (P<0.05); after the treatment, the observation group was higher than the control group in ADL scores, lower than the control group in NIHSS scores (P<0.05); total effective rate of the observation group was 91.49% (43/47), higher than 73.91% (34/36) of the control group (P<0.05); total incidence of adverse reaction of the observation group was no significant with control group (P>0.05). ConclusionXifeng Huatan Tongluo Tang combined with Western medicine in treating the elderly with ischemic stroke could effectively relieve inflammatory reaction, promote the recovery of neurological function and improve hypercoagulable state with high safety.

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备注/Memo

备注/Memo:
韦辉燕（1985—），女，主治医师。研究方向：脑病的中西医结合诊治。海南省自然科学基金青年基金（818QN324）。
更新日期/Last Update: 2021-04-15