[1]陈威,黄庆仪,蒙宇华.大黄附子汤对急性胰腺炎患者血清IL-22及IL-13表达的影响[J].西部中医药,2016,29(05):1-4.
　CHEN Wei,HUANG Qingyi,MENG Yuhua.The Influence of DaHuang FuZi Tang on the Expressions of IL-22 and IL-13 of the Patients with Acute Pancreatitis[J].Western Journal of Traditional Chinese Medicine,2016,29(05):1-4.
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大黄附子汤对急性胰腺炎患者血清IL-22及IL-13表达的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年05期
页码:
1-4
栏目:
出版日期:
2016-05-15

文章信息/Info

Title:
The Influence of DaHuang FuZi Tang on the Expressions of IL-22 and IL-13 of the Patients with Acute Pancreatitis
文章编号:
1004-6852(2016)05-0001-04
作者:
陈威，黄庆仪，蒙宇华
广西中医药大学附属瑞康医院，广西 南宁 530011
Author(s):
CHEN Wei, HUANG Qingyi, MENG Yuhua
Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China
关键词:
急性胰腺炎; 白细胞介素-22; 白细胞介素-13; 大黄附子汤
Keywords:
acute pancreatitis;  IL-22;  IL-13;  DaHuang FuZi Tang
分类号:
R576
文献标志码:
A
摘要:
目的：观察急性胰腺炎患者血清白细胞介素-22(IL-22)和白细胞介素-13(IL-13)水平变化情况，探讨大黄附子汤防治急性胰腺炎的作用机制。方法：将急性胰腺炎患者40例按就诊顺序以1∶1分为2组。对照组采用基础治疗，治疗组在对照组基础上加大黄附子汤治疗，连续治疗2周。观察临床疗效并采用ELISA法检测入院0、7、14天 时患者血清IL-22及IL-13水平；应用荧光定量PCR法检测血清IL-22及IL-13表达。结果：总有效率治疗组为85.00%，对照组为60.00%；病死率治疗组为5.00%，对照组为20.00%，2组临床疗效比较差异有统计学意义（P＜0.05)。治疗前治疗组患者血清IL-22及IL-13水平呈上升趋势，治疗后呈下降趋势，与治疗前比较差异有统计学意义（P＜0.05)。对照组血清IL-22及IL-13水平较治疗前无明显变化（P＞0.05)。结论：大黄附子汤可通过下调患者血清IL-22和IL-13等炎性因子的表达，降低炎症反应，起到缓解急性胰腺炎的作用。
Abstract:
Objective: To explore the mechanism of DaHuang FuZi Tang in preventing and treating acute pancreatitis(AP) by observing the changes of IL-22 and IL-13 of the patients. Methods: Forty patients were divided into two groups according to the visiting order 1:1. The control group adopted routine treatment, and the treatment group took DaHuang FuZi Tang on the foundation of routine treatment for two weeks consecutively. The levels of IL-22 and IL-13 of the patients were detected at the admission day, the seventh day and 14th day with ELISA method; the expressions of IL-22 and IL-13 were measured by fluroscent quantitation PCR method. Results: Total effective rate of the treatment group was 85.00%, higher than 60.00% of the control group; mortality rate of the treatment group was 5.00%, lower than 20.00% of the control group, and the difference showed statistical meaning (P＜0.05). The levels of IL-22 and IL-13 of the patients in the treatment group rose before treating, while decreased after treating, and the difference had statistical meaning compared with before treating(P＜0.05). The levels of IL-22 and IL-13 showed no obvious changes in the control group after treating compared with before treating(P＞0.05). Conclusion: DaHuang FuZi Tang could alleviate acute pancreatitis by down regulating the expressions of IL-22 and IL-13, and decreasing inflammatory reactions.

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备注/Memo

备注/Memo:
收稿日期：2015-02-11作者简介：陈威(1980—)，男，主治医师。研究方向：急危重症的中西医结合治疗。
更新日期/Last Update: 2016-05-15