人知降糖胶囊质量标准研究-《西部中医药》

文章信息/Info

作者:: 陈衍斌1，2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2，方欢乐3，卢新义1，2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2，刘峰1，2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2，马久太1，2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2; 1 陕西国际商贸学院，陕西咸阳 712000； 2 陕西步长制药有限公司； 3 西安培华学院医学院

Author(s):: CHEN Yanbin1,2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2, FANG Huanle3, LU Xinyi1,2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2, LIU Feng1,2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2, MA Jiutai1,2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2' target="_blank" rel="external">2; 1 Shaanxi Institute of International Trade & Commerce, Xianyang 712000, China; 2 Shaanxi Buchang Pharmaceuticals Company, Ltd.; 3 Medical School, Xi′an Peihua University

Keywords:: RenZhi glucose-lowering capsules; sarsasapogenin; quality standard

摘要:: 目的：对人知降糖胶囊的质量标准进行研究，建立TLC鉴别方法和菝葜皂苷元的含量测定方法。方法：以甲醇-水(94∶6)为流动相；流速：1.0 mL/min；采用蒸发光散射检测器：漂移管温度80℃，氮气流速每分钟1.7 L。结果：薄层鉴别系统分离度好，专属性强；菝葜皂苷元含量在0.3610～3.610 μg范围内呈良好的线性关系，回归方程：Y=1.514 4X+5.088 3(r=0.999 8)，平均加样回收率为100.15%，RSD为1.26%。结论：该质量标准分离效果好、专属性强、结果准确可靠，可以有效控制人知降糖胶囊质量。

Abstract:: Objective:To study quality standard of RenZhi glucose-lowering capsules, establish TLC identification method and content determination methods for sarsasapogenin. Methods: Methanol-water (94:6) was selected as the mobile phase, flow rate: 1.0mL/min; HPLC-ELSD was used; the temperature of drift tube was 80℃, nitrogen flow velocity was 1.7L/min. Results: TLC identification system showed good separation effects and strong specificity, the contents of sarsasapogenin were in the good linear relationship ranged from 0.3610 to 3.610 μg, regression equation: Y=1.514 4X+5.088 3(r=0.999 8), average recovery rate was 100.15%, RSD was 1.26%. Conclusion: The quality standard, showing good separation effects, strong specificity, accurate and reliable results, could effectively control the quality of RenZhi glucose-lowering capsules.