[1]陈锡康,田华琴△.三阴性乳腺癌的治疗现状及进展[J].西部中医药,2018,31(11):135-140.
　CHEN Xikang,TIAN Huaqin.Therapeutic Status and Progress of Triple Negative Breast Cancer[J].Western Journal of Traditional Chinese Medicine,2018,31(11):135-140.
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三阴性乳腺癌的治疗现状及进展()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年11期
页码:
135-140
栏目:
出版日期:
2018-11-15

文章信息/Info

Title:
Therapeutic Status and Progress of Triple Negative Breast Cancer
文章编号:
1004-6852(2018)11-0135-06
作者:
陈锡康1，2，田华琴2△
1 广州中医药大学，广东 广州 510000； 2 广州中医药大学附属佛山市中医院
Author(s):
CHEN Xikang1, 2, TIAN Huaqin 2△
1 Guangzhou University of Chinese Medicine, Guangzhou 510000, China; 2 Foshan Hospital of TCM Affiliated to Guangzhou University of Chinese Medicine
关键词:
三阴性乳腺癌; 治疗现状; 综述
Keywords:
triple negative breast cancer;  therapeutic status;  review
分类号:
R737.9
文献标志码:
A
摘要:
对三阴性乳腺癌(triple negative breast cancer，TNBC）相关治疗的国内外研究现状及进展作一综述，指出TNBC是乳腺癌其中的一个亚型，其雌激素受体(estrogen receptor，ER)、孕激素受体(progesterone receptor，PR)以及人类表皮生长因子受体2(human epidermal growth factor receptor 2，HER-2)的表达状态均为阴性。TNBC具有独特的生物学及临床特征，较其他亚型的乳腺癌有更强的侵袭性，而且无病生存期较短，软组织及内脏转移率高，5年内死亡率较非TNBC患者高。目前治疗乳腺癌主要以ER，PR，HER2为靶点，但TNBC患者因为缺少靶点，不能从内分泌治疗及靶向治疗中获益，导致其预后差、复发转移率及死亡率高。因此TNBC成为近年乳腺癌研究和关注的焦点。
Abstract:
By reviewing the status and the progress of the studies at home and abroad related to the treatment for triple negative breast cancer (TNBC), it was pointed out that TNBC is one subtype of breast cancer, the expressions of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2) are negative. Compared with other subtype of breast cancer, TNBC owned the unique biological and clinical characteristics, and it possessed the features of being more aggressive, shorter disease-free survival period, high soft tissue and visceral metastasis rates, the mortality rate within five years higher than that of the patients with NTNBC. Currently, the treatment of breast cancer mainly is mainly targeted at ER, PR and HER2, since the patients with TNBC lacked the target spots, they couldn't benefit from endocrine therapy and targeted therapy, which caused poor prognosis, high recurrence and metastasis rate and mortality rate. Therefore, TNBC has become the focus of the study on breast cancer in recent years.

相似文献/References:

[1]张佳慧,于明薇,王笑民,等.三阴性乳腺癌中西医治疗研究进展[J].西部中医药,2024,37(04):91.[doi:10.12174/j.issn.2096-9600.2024.04.18]
　ZHANG Jiahui,YU Mingwei,WANG Xiaomin,et al.Progress of Research on Chinese and Western Medicine Treatment of Triple-negative Breast Cancer[J].Western Journal of Traditional Chinese Medicine,2024,37(11):91.[doi:10.12174/j.issn.2096-9600.2024.04.18]

备注/Memo

备注/Memo:
收稿日期：2017-10-20 *基金项目：佛山市科技局科研课题(编号2015AB00342)。 作者简介：陈锡康(1992—)，男，硕士学位。研究方向：肿瘤疾病的中西医结合治疗。 △通讯作者：田华琴(1963—)，女，主任医师。研究方向：肿瘤疾病的中西医结合治疗。
更新日期/Last Update: 2018-11-15