[1]高淑美.基于大数据分析“肺与大肠相表里”理论在新型冠状病毒肺炎中的应用[J].西部中医药,2020,33(08):1-4.[doi:10.12174/j.issn.1004-6852.2020.08.01]
　GAO Shumei.Application of "Exterior-interior Relationship between the Lung and Large Intestine" to COVID-19 Based on Big Data[J].Western Journal of Traditional Chinese Medicine,2020,33(08):1-4.[doi:10.12174/j.issn.1004-6852.2020.08.01]
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基于大数据分析“肺与大肠相表里”理论在新型冠状病毒肺炎中的应用
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年08期
页码:
1-4
栏目:
出版日期:
2020-08-15

文章信息/Info

Title:
Application of "Exterior-interior Relationship between the Lung and Large Intestine" to COVID-19 Based on Big Data
文章编号:
1004-6852(2020)08-0001-04
作者:
高淑美
甘肃医学院，甘肃 平凉 744000
Author(s):
GAO Shumei
Gansu Medical College, Pingliang 744000, China
关键词:
新型冠状病毒肺炎; 肺与大肠相表里; 方药; 基因; 大数据
Keywords:
COVID-19;  exterior-interior relationship between the lung and large intestine;  prescription and herbs; gene;  big data
分类号:
R563.1
DOI:
10.12174/j.issn.1004-6852.2020.08.01
文献标志码:
A
摘要:
目的:整理分析与“肺与大肠相表里”理论相关的研究文献，为新型冠状病毒肺炎(Corona Virus Disease 2019，COVID-19)(简称新冠肺炎)的治疗提供新的思路和参考依据。方法:在中国知识基础设施工程文献数据库检索有关“肺与大肠相表里”“新冠肺炎”的相关研究文献，按照文献纳入标准，使用bibexcel软件绘制关键词矩阵，采用VOSviewer软件绘制网络图谱。分析相关文献中涉及与新冠肺炎有关的方药、核心方剂、基因名称及研究中出现的高频关键词。结果：从该理论所涉及的方药来看，核心中药以生地黄、玄参、火麻仁为主，主要功效是清热凉血、润肠通便。核心方剂以射干麻黄汤、清热化痰通腑方、宣白承气汤为主，其主要功效是清肺泻下止咳；从涉及的基因来看，处于核心地位的有辅助性T细胞17(T helper cell 17,Th17)、干扰素γ(interferon γ，IFN-γ)、白细胞介素6(interleukin-6，IL-6)，其主要机制可能是通过破坏肠道菌群微生态平衡；“肺与大肠相表里”理论与新冠肺炎相关性研究的核心关键词有宣畅气机、开窍醒神、达原饮、肺炎、细胞因子风暴，说明要重视细胞因子风暴参与的机制研究以及在辨证论治的基础上应用达原饮。结论：为了更好地治疗新冠肺炎，应以“肺与大肠相表里”为指导原则，临证中注意调节患者呼吸功能与大肠传导功能，治疗时注重保持患者肠道菌群的平衡，保持大便通畅，达到标本同治的目的。
Abstract:
Objective: To provide new thinking and reference for the therapy of COVID-19 by arranging and analyzing the research literature related to the theory "exterior-interior relationship between the lung and large intestine". Methods: The literature related to the theory "exterior-interior relationship between the lung and large intestine" and COVID-19 were searched in CNKI, according to literature inclusion criteria, bibexcel software was used to draw keyword matrix, VOS viewer software was adopted to draw network map. To analyze the herbs and prescription for COVID-19, core prescription, genetic name and high-frequency keywords appeared in the study in the related literature. Results: According to the prescripions and herbs involved in the theory, the core herbs were Shengdihuang (Rehmannia glutinosa Libosch.), Xuanshen (Scrophulariae Radix) and Huomaren (Cannabis Fructus) mainly, its main effects were heat-clearing blood-cooling, loosening bowel to relieve constipation. The core prescriptions were Shegan Mahuang Tang, Qingre Huatan Tongfu prescription, Xuanbai Chengqi Tang and others, and its main effects were clearing lung, purgation and relieving cough; according to the genes, the core genes were Th17 cells, IFN-γ and IL-6, and its main mechanism might be through destroying the microecological balance of intestinal flora; the core keywords of the related study between the theory and COVID-19 were dispersing Qi movement, inducing resuscitation, Dayuan drink, pneumonia and cytokine storm, which demonstrated that we should emphasize the study on the mechanism that cytokine storm participated in and the application of Dayuan drink based on syndrome differentiation and treatment. Conclusion: In order to treat COVID-19 better, exterior-interior relationship between the lung and large intestine should be chosen as the guiding principle, we should regulate respiratory function and conduction function of large intestine in clinical practice, pay attention to the balance of intestinal flora, keep a normal bowel movement, and achieve the aim of simultaneous treatment of root and tip.

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[11]高淑美.基于大数据分析“肺与大肠相表里”理论在新型冠状病毒肺炎中的应用[J].西部中医药,2020,33(S1):86.
　GAO Shumei.Application of "Exterior-interior Relationship between the Lung and Large Intestine" to COVID-19 Based on Big Data[J].Western Journal of Traditional Chinese Medicine,2020,33(08):86.

备注/Memo

备注/Memo:
收稿日期：2020-06-20*基金项目：全国第四次中药资源普查甘肃省崆峒区中药资源普查项目(GSZYPC201711)。作者简介：高淑美(1963—)，女，硕士学位,讲师。研究方向：医学教育管理、妇产科学研究。
更新日期/Last Update: 2020-08-15