[1]余胜.脉络舒通丸口服联合肛泰栓纳肛对混合痔切除术后患者的影响[J].西部中医药,2021,34(03):130-134.[doi:10.12174/j.issn.2096-9600.2021.03.33]
　YU Sheng.Impacts of Oral Administration of Mailuo Shutong Pills Combined with Anorectal Gangtai Suppository on the Patients after Mixed Hemorrhoidectomy[J].Western Journal of Traditional Chinese Medicine,2021,34(03):130-134.[doi:10.12174/j.issn.2096-9600.2021.03.33]
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脉络舒通丸口服联合肛泰栓纳肛对混合痔切除术后患者的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年03期
页码:
130-134
栏目:
出版日期:
2021-03-15

文章信息/Info

Title:
Impacts of Oral Administration of Mailuo Shutong Pills Combined with Anorectal Gangtai Suppository on the Patients after Mixed Hemorrhoidectomy
作者:
余胜
安徽医科大学第一附属医院中医科，安徽 合肥 230000
Author(s):
YU Sheng
TCM Department, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, China
关键词:
混合痔; 切除术; 脉络舒通丸; 肛泰栓
Keywords:
mixed hemorrhoids; excision; pills; suppository
分类号:
R657
DOI:
10.12174/j.issn.2096-9600.2021.03.33
摘要:
目的探讨脉络舒通丸口服联合肛泰栓纳肛对混合痔切除术后患者临床症状及创面愈合的影响。 方法将混合痔切除术后患者400例随机分为常规组及研究1、2、3组各100例。常规组予常规方法干预，研究组1、2、3组分别给予常规方法+肛泰栓纳肛、常规方法+脉络舒通丸口服、常规方法+脉络舒通丸口服+肛泰栓纳肛。观察干预前后患者肛门坠胀、肛缘水肿积分，干预前及干预3天、1周疼痛程度，干预1周后肉芽组织生长情况及创面愈合时间；观察干预前后血清白细胞介素6（interleukin-6，IL-6）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）和血管表皮生长因子（vascular epidermal growth factor，VEGF）水平及不良反应。 结果干预后各组患者肛门坠胀、肛缘水肿积分均降低（P＜0.05），研究1、2、3组低于常规组（P＜0.05），研究3组低于研究1、2组（P＜0.05）。各组患者疼痛评分均随干预时间的延长而降低（P＜0.05），干预后研究1、2、3组评分均低于常规组（P＜0.05），研究3组低于研究1、2组（P＜0.05）。干预1周后各组肉芽组织生长情况分级与干预前比较差异显著（P＜0.05），且研究1、2、3组优良率高于常规组（P＜0.05），研究3组高于研究1、2组（P＜0.05）。研究1、2、3组创面愈合时间均短于常规组（P＜0.05），研究3组短于研究1、2组（P＜0.05）。各组干预后血清IL-6和TNF-α水平均降低（P＜0.05），研究1、2、3组均低于常规组（P＜0.05），研究3组低于研究1、2组（P＜0.05）。干预后各组血清VEGF水平均升高，研究1、2、3组均高于常规组（P＜0.05），研究3组高于研究1、2组（P＜0.05）。各组均未见不良反应发生。 结论在常规治疗的基础上口服脉络舒通丸、纳肛肛泰栓能够减轻混合痔切除术后患者肛门坠胀、肛缘水肿和疼痛感，能促进肉芽组织生长和创面愈合，改善血清IL-6、TNF-α和VEGF水平，二者联用效果更佳，且安全可靠。
Abstract:
ObjectiveTo explore the effects of oral administration of Mailuo Shutong pills and anorectal Gangtai suppository on clinical symptoms and wound healing of the patients after mixed hemorrhoidectomy. MethodsAll 400 patients were allocated to conventional group and the study groups of No. 1, 2 and 3 randomly, 100 cases each group. Conventional group were intervened by conventional method, the study groups of No. 1, 2 and 3 accepted conventional method+anorectal Gangtai suppository, conventional method+oral administration of Mailuo Shutong pills and conventional method+oral administration of Mailuo Shutong pills+anorectal Gangtai suppository respectively. To observe anal distension, perianal edema score of the patients before and after the intervention, pain degrees before the intervention, after three-day intervention and one-week intervention, the growth of granulation tissue and wound healing time after one-week intervention; to observe the levels of IL-6, TNF-α and VEGF, and adverse reaction before and after the intervention. ResultsThe scores of anal distension and perianal edema lowered in different groups after the intervention (P<0.05), the study groups of No. 1, 2 and 3 were lower than conventional group (P<0.05), the study group No.3 was lower than the study groups of No.1 and 2 (P<0.05). Pain scores reduced in different groups as the intervention time prolonged (P<0.05), the scores of the study groups of No. 1, 2 and 3 were lower than these of conventional group (P<0.05), the study group No.3 was lower than the study groups of No.1 and 2 (P<0.05). The difference was significant when grading of granulation tissue growth in different groups one week after the intervention was compared with these before the intervention (P<0.05), the excellent rates of the study groups of No. 1, 2 and 3 were higher than that of the conventional group (P<0.05), the study group No.3 was higher than the study groups of No.1 and 2 (P<0.05). Wound healing time of the study groups of No. 1, 2 and 3 were shorter than that of the conventional group (P<0.05), the study group No.3 was shorter than the study group No,1 and 2 (P<0.05). After the intervention, the levels of IL-6 and TNF-α in different groups lowered (P<0.05), the study groups of No. 1, 2 and 3 were lower than conventional group (P<0.05), the study group No.3 was shorter than the study group No,1 and 2 (P<0.05). The levels of VEGF in the serum rose after the intervention, the study groups of No. 1, 2 and 3 were higher than conventional group (P<0.05), the study group No.3 was higher than the study group No,1 and 2 (P<0.05). No adverse reaction occur in different groups. ConclusionBased on conventional therapy, oral administration of Mailuo Shutong pills and anorectal Gangtai suppository could relieve anal distension, perianal edema and pain, promote granulation tissue growth and wound healing, improve the levels of IL-6, TNF-α and VEGF, the combination of both drugs could gain better effects, which is safe and reliable.

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备注/Memo

备注/Memo:
余胜（1983—），男，硕士学位，主治医师。研究方向：肛肠疾病的中医诊治。
更新日期/Last Update: 2021-03-05