[1]林宁,王嘉俊,廖伍萍,等.中西医结合治疗桥本甲状腺炎疗效的Meta分析[J].西部中医药,2022,35(05):62-67.[doi:10.12174/j.issn.2096-9600.2022.05.16]
 LIN Ning,WANG Jiajun,LIAO Wuping,et al.Meta Analysis of Clinical Effects of Integrative Medicine in the Treatment of Hashimoto's Thyroiditis[J].Western Journal of Traditional Chinese Medicine,2022,35(05):62-67.[doi:10.12174/j.issn.2096-9600.2022.05.16]
点击复制

中西医结合治疗桥本甲状腺炎疗效的Meta分析
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年05期
页码:
62-67
栏目:
循证医学
出版日期:
2022-05-15

文章信息/Info

Title:
Meta Analysis of Clinical Effects of Integrative Medicine in the Treatment of Hashimoto's Thyroiditis
作者:
林宁 王嘉俊 廖伍萍 文莹
广东省第二人民医院中医科,广东 广州 510317
Author(s):
LIN Ning WANG Jiajun LIAO Wuping WEN Ying
TCM Department, Guangdong Second Provincial People's Hospital, Guangzhou 510317, China
关键词:
桥本甲状腺炎随机对照试验中西医结合Meta分析
Keywords:
Hashimoto's thyroiditisrandomized controlled trialintegrative medicineMeta analysis
分类号:
R581
DOI:
10.12174/j.issn.2096-9600.2022.05.16
文献标志码:
A
摘要:
目的系统评价中西医结合治疗桥本甲状腺炎(Hashimoto's thyroiditis,HT)的疗效,为临床治疗桥本甲状腺炎提供循证医学证据。 方法搜索2009年1月至2019年12月发表的中西医结合与单纯西药治疗HT的随机对照试验(RCTs)。对这些文献进行筛选,提取符合纳入标准的数据。采用Stata 15.0软件分析数据,并对纳入研究进行发表偏倚分析和敏感性分析。 结果共纳入文献11篇,包括932例患者。观察组临床疗效明显优于单纯西药组(OR=1.24,95%CI[1.02,1.50],P<0.005)。观察组在改善甲状腺过氧化酶抗体(thyroid peroxidase antibody,TPOAb)和甲状腺球蛋白抗体(thyroglobulin antibody,TGAb)方面明显优于单纯西药组(SMD=-2.70,95%CI[-3.56,-1.83],P<0.01;SMD=-2.08,95%CI[-3.03,-1.34],P<0.05)。 结论中西医联合治疗桥本甲状腺炎临床疗效优于单纯西药组,可明显降低TGAb、TpoAb浓度。
Abstract:
ObjectiveTo provide evidence-based medicine evidence for clinical therapy of Hashimoto's thyroiditis (HT) by systematically assessing clinical effects of integrative medicine in the treatment of HT. MethodsAfter searching RCTs on integrative medicine and single Western medicine in treating HT between January, 2009 and December, 2019, the data were screened to extract the data met the inclusion criteria. Stata 15.0 software was adopted to analyze the data, publication bias analysis and sensitivity analysis were performed for the included studies. ResultsAll 11 articles were included, involving 932 patients. Clinical effects of the observation group were notably better than these of single Western medicine group (OR=1.24, 95%CI[1.02, 1.50], P<0.005). The observation group was better than single Western medicine group in improving TPOAb and TGAb notably (SMD=-2.70,95%CI[-3.56,-1.83], P<0.01; SMD=-2.08, 95%CI[-3.03,-1.34],P<0.05). ConclusionIntegrative medicine is superior to single Western medicine group in the treatment of HT, it could notably decrease the concentrations of TGAb and TpoAb.

相似文献/References:

[1]王军,邓军红△,指导:张剑锋.针刺治疗面肌痉挛随机对照临床试验Meta分析[J].西部中医药,2013,26(08):61.
 WANG Jun,DENG Junhong,Director: ZHANG Jianfeng.Meta Analysis on Randomized Controlled Trials of Acupuncture in Treating Facial Spasm[J].Western Journal of Traditional Chinese Medicine,2013,26(05):61.
[2]任芳,徐厚谦△.黄芪注射液治疗糖尿病肾病随机对照试验报告质量评价[J].西部中医药,2013,26(12):1.
 REN Fang,XU Houqian.Quality Evaluation of the Report for Randomized Controlled Trials of HuangQi Injection in Treating Diabetic Nephropathy[J].Western Journal of Traditional Chinese Medicine,2013,26(05):1.
[3]任芳,徐厚谦△.黄芪注射液治疗糖尿病肾病有效性及安全性的系统评价[J].西部中医药,2014,27(01):77.
 REN Fang,XU Houqian.Systematic Review of the Effectiveness and Safety of HuangQi Injection in Treating Diabetic Nephropathy[J].Western Journal of Traditional Chinese Medicine,2014,27(05):77.
[4]蹇文渊,路雪婧,段俊国△.单病例随机对照设计研究现状与中医辨证论治的思考[J].西部中医药,2015,28(05):47.
[5]王倩,孙远岭△,李继君.七味白术散治疗小儿脾虚泄泻临床研究Meta分析[J].西部中医药,2015,28(09):62.
[6]张旭辉,杨虹.咳喘宁胶囊治疗稳定期慢性阻塞性肺疾病的疗效评价[J].西部中医药,2016,29(03):1.
 ZHANG Xuhui,YANG Hong.Evaluation of Clinical Effects of KeChuanNing Capsules in Treating Chronic Obstructive Pulmonary Disease at Stable Stage[J].Western Journal of Traditional Chinese Medicine,2016,29(05):1.
[7]卢如玲,古子娟,袁烁.补肾中药联合达英-35治疗多囊卵巢综合征疗效的Meta分析[J].西部中医药,2018,31(01):64.
 LU Ruling,GU Zijuan,YUAN Shuo.Meta Analysis of Clinical Effects of Kidney-tonifying Herbs Combined with Diane-35 in Treating Polycystic Ovarian Syndrome[J].Western Journal of Traditional Chinese Medicine,2018,31(05):64.
[8]马燕云,陈秋野,唐 红△.健脾消瘿汤治疗桥本甲状腺炎的临床研究[J].西部中医药,2019,32(01):1.
 MA Yanyun,CHEN Qiuye,TANG Hong.Clinical Study on JianPi XiaoYing Decoction in Treating Hashimoto′s Thyroiditis[J].Western Journal of Traditional Chinese Medicine,2019,32(05):1.
[9]滕雅娟,张燕,谭志敏,等.丹参酮联合优甲乐对桥本甲状腺炎伴甲状腺功能减退患者免疫功能的影响[J].西部中医药,2019,32(03):102.
 TENG Yajuan,ZHANG Yan,TAN Zhimin,et al.Effects of Tanshinone and Euthyrox on Immunologic Function of Hashimoto's Thyroiditis Accompanying Hypothyroidism[J].Western Journal of Traditional Chinese Medicine,2019,32(05):102.
[10]贾静,朱秀娟△,安静,等.保妇康栓治疗宫颈人乳头瘤病毒感染临床疗效的Meta分析[J].西部中医药,2019,32(05):51.
 JIA Jing,ZHU Xiujuan,AN Jing,et al.Meta Analysis of Clinical Effects of BaoFuKang Suppository in the Treatment for Cervical HPV Infection[J].Western Journal of Traditional Chinese Medicine,2019,32(05):51.

备注/Memo

备注/Memo:
林宁(1975—),女,博士学位,副主任医师。研究方向:代谢及自身免疫疾病的中西医结合治疗。2016年广东省中医药局常规科研项目(20162005)。
更新日期/Last Update: 2022-06-24