[1]沈毅韵,庄承.徐氏温阳平喘方治疗小儿寒哮（轻度）临床观察[J].西部中医药,2022,35(05):127-131.[doi:10.12174/j.issn.2096-9600.2022.05.29]
　SHEN Yiyun,ZHUANG Cheng.Clinical Observation on Xu's Warming-Yang Relieving-asthma Prescription in the Treatment of Cold Asthma in Children (Mild)[J].Western Journal of Traditional Chinese Medicine,2022,35(05):127-131.[doi:10.12174/j.issn.2096-9600.2022.05.29]
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徐氏温阳平喘方治疗小儿寒哮（轻度）临床观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年05期
页码:
127-131
栏目:
衷中参西
出版日期:
2022-05-15

文章信息/Info

Title:
Clinical Observation on Xu's Warming-Yang Relieving-asthma Prescription in the Treatment of Cold Asthma in Children (Mild)
作者:
沈毅韵, 庄承
上海中医药大学附属第七人民医院儿科，上海 200137
Author(s):
SHEN Yiyun, ZHUANG Cheng
Pediatrics, Seventh People's Hospital of Shanghai University of TCM, Shanghai 200137, China
关键词:
儿童; 寒性哮喘; 徐氏温阳平喘方; 肺功能; 临床研究
Keywords:
children; cold asthma; warming- relieving-asthma prescription; pulmonary function; clinical study
分类号:
R249.2
DOI:
10.12174/j.issn.2096-9600.2022.05.29
文献标志码:
B
摘要:
目的观察徐氏温阳平喘方治疗小儿寒哮的临床疗效。 方法将寒性哮喘患儿88例随机分为治疗组与对照组各44例，两组均在普米克令舒（吸入用布地奈德混悬液）、博利康尼（硫酸特布他林雾化液）、爱全乐（吸入用异丙脱溴铵溶液）雾化治疗的基础上，治疗组加服徐氏温阳平喘方，对照组加服小青龙汤，两组每天雾化2次，服用中药1剂，共治疗1周。比较两组临床疗效、中医证候积分、嗜酸粒细胞（eosinophil，EOS）百分比、C反应蛋白（C-reactive protein，CRP）、降钙素原（procalcitonin，PCT）、血清总免疫球蛋白E（total immunoglobulin E，TIgE）及肺功能，记录治疗后血尿粪常规、肝肾功能、心电图异常及其他不良反应发生情况。 结果治疗组疗效优于对照组，差异有统计学意义（P＜0.05）。中医证候积分两组治疗后均较治疗前改善，差异有统计学意义（P＜0.05），治疗组次要证候积分低于对照组（P＜0.05）。两组治疗后EOS百分比、TIgE、CRP、PCT均较治疗前改善，差异有统计学意义（P＜0.05），其中治疗组EOS百分比、CRP、PCT改善优于对照组（P＜0.05）。两组治疗后第一秒用力呼气量（forced expiratory volume in the first second,FEV1）、用力肺活量（forced vital capacity,FVC）、第一秒用力呼气量与用力肺活量比值（FEV1/FVC）、呼气峰值流速（peak expiratory flow,PEF）、用力呼气50%肺活量（forced expiratory flow 50，FEF50）、用力呼气75%肺活量（forced expiratory flow 75，FEF75）均较治疗前改善，差异有统计学意义（P＜0.05），治疗后两组肺功能相当，差异无统计学意义（P＞0.05）；两组均未见明显不良反应发生。 结论在西医常规治疗的基础上联合徐氏温阳方治疗小儿寒哮（轻度）疗效优于联合小青龙汤治疗，能够改善患者生活质量及肺功能，且安全性较好。
Abstract:
ObjectiveTo observe clinical effects of Xu's warming-Yang relieving-asthma prescription in the treatment of cold asthma in children. MethodsAll 88 children with cold asthma were randomized into the treatment group and the control group, with 44 cases in each group, based on atomization inhalation of pulmicort, bricanyl and atrovent, the treatment group took Xu's warming-Yang relieving-asthma prescription, and the control group Xiaoqinglong decoction, both groups were atomized twice a day, and took one dose of herb, treating for one week. To compare clinical effects, TCM syndrome scores, the percentage of eosinophils (EOS%), C-reactive protein (CRP), procalcitonin (PCT) and serum total IgE (TIgE), pulmonary function between both groups, to record the incidence of adverse reaction, ECG abnormality, liver and kidney function, blood, urine and fecal routine examinations after the treatment. ResultsThe treatment group was better than the control group in clinical effects, and the difference had statistical meaning (P<0.05). TCM syndrome scores of both groups after treatment were improved than these before treating, and the difference was statistically significant (P<0.05), the treatment group was lower than the control group in the scores of secondary symptons (P<0.05). After treating, EOS%, TIgE, CRP and PCT of both groups were improved than these before treating, and the difference was statistically significant (P<0.05), the treatment group was superior to the control group in EOS%, CRP and PCT (P<0.05). After treatment, FEV1, FVC, FEV1/FVC, PEF, FEF50 and FEF75 of both groups were improved than these before treatment, and the difference was statistically significant (P<0.05), after the treatment, pulmonary function were the same in both groups, and the difference had no statistical meaning (P>0.05); no adverse reaction happened. ConclusionClinical effects of Xu's warming-Yang relieving-asthma prescription on the foundation of conventional therapy are superior to these of conventional therapy jointed with Xiaoqinglong decoction in the treatment of cold asthma in children (mild), it could improve the patients’ quality of life and pulmonary function with better safety.

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备注/Memo

备注/Memo:
沈毅韵（1982—），女，博士学位，副主任医师。研究方向：小儿呼吸系统疾病的中医治疗。浦东新区中医学科建设三年行动计划建设项目（PDZY-2018-0609）；上海市卫计委中发办中西医结合儿科重点专科建设。
更新日期/Last Update: 2022-06-24