[1]曹一钦,文昌晖,王秀琳,等.基于网络药理学的金银花-连翘药对干预银屑病的分子机制[J].西部中医药,2022,35(11):8-15.[doi:10.12174/j.issn.2096-9600.2022.11.03]
　CAO Yiqin,WEN Changhui,WANG Xiulin,et al.Molecular Mechanism of Jinyinhua-Lianqiao Couplet Medicines in the Intervention for Psoriasis Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2022,35(11):8-15.[doi:10.12174/j.issn.2096-9600.2022.11.03]
点击复制

基于网络药理学的金银花-连翘药对干预银屑病的分子机制
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年11期
页码:
8-15
栏目:
出版日期:
2022-11-15

文章信息/Info

Title:
Molecular Mechanism of Jinyinhua-Lianqiao Couplet Medicines in the Intervention for Psoriasis Based on Network Pharmacology
作者:
曹一钦1, 文昌晖1,2, 王秀琳1, 张玲丽1, 贾敏2, 李斌3
1.贵州中医药大学，贵州 贵阳 550001
2.贵州中医药大学第一附属医院皮肤科
3.上海中医药大学附属岳阳中西医结合医院
Author(s):
CAO Yiqin1, WEN Changhui1,2, WANG Xiulin1, ZHANG Lingli1, JIA Min2, LI Bin3
1.Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China
2.Department of Dermatology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
3.Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
关键词:
银屑病; 网络药理学; 金银花-连翘; 机制
Keywords:
psoriasis; network pharmacology; -; mechanism
分类号:
R275.9
DOI:
10.12174/j.issn.2096-9600.2022.11.03
文献标志码:
A
摘要:
目的基于网络药理学原理探讨消疕汤核心药对金银花-连翘干预银屑病的分子通路及作用机制。 方法应用中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmaco-logy database and analysis platform，TCMSP)检索金银花、连翘化学成分、作用靶点，并通过GeneCards数据库获取银屑病差异性靶点基因，预测中药与银屑病相关的作用靶点，通过STRING平台构建蛋白质-蛋白质相互作用信息网络（PPI），运用DAVID数据库对筛选出的靶点基因进行基因富集分析，获得基因本体论功能富集分析（gene ontology，GO）和KEGG富集分析（kyoto encyclopedia of genes and genomes，KEGG）信号通路注释结果，构建“中药成分-关键靶标-主要通路”的可视化网络图，探究金银花-连翘药对干预银屑病的分子作用机制。 结果金银花-连翘药对干预银屑病，共预测得到28个活性成分，涉及核心靶标基因127个，生物功能138个和信号通路155个。 结论金银花-连翘药对主要活性成分通过多靶点、多通路干预银屑病，主要涉及核受体的活性、转录因子活性、细胞因子受体结合、细胞因子生物功能等和白细胞介素17(interleukin-17，IL-17)信号通路、肿瘤坏死因子(tumor necrosis factor,TNF)信号通路、磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase，PI3K)-蛋白激酶B(protein kinase B，Akt)信号通路等。
Abstract:
ObjectiveTo discuss molecular pathway and mechanism of Xiaobi Tang core couplet medicine Jinyinhua (Lonicerae japonicae flos)-Lianqiao (Forsythiae fructus) in the intervention of psoriasis based on network pharmacology. MethodsChemical ingredients and targets of Jinyinhua and Lianqiao were retrieved from TCMSP, and differential target genes of psoriasis were obtained from GeneCards database, to predict psoriasis-related targets in the herbs, to construct PPI via STRING platform, gene enrichment of the screened targets were analyzed by using DAVID database, to obtain the annotation notes of GO biological function and KEGG signaling pathway, to construct visual network diagram of “herbal ingredients-key targets-main pathway” and explore the molecular mechanism of materia medica in the intervention of psoriasis. ResultsIn the intervention of psoriasis by couplet medicine Jinyinhua-Lianqiao, 28 active ingredients were gained by the prediction, involving 127 core target genes, 138 biological function and 155 signaling pathway. ConclusionJinyinhua-Lianqiao could intervene psoriasis by many targets and pathways, mainly involving the activity of nuclear receptor, the activity of transcription factors, cytokine receptor binding, cytokine biological function and others, as well as IL-17 signaling pathway, TNF signaling pathway and P13K-Akt signaling pathway.

相似文献/References:

[1]冯德海,更桑,安维梅.藏药治疗银屑病60例临床疗效观察[J].西部中医药,2012,25(05):46.
　FENG De-hai,GENG Sang,AN Wei-mei.Observation on Curative Effects of Tibetan Medicine in Treating 60 Cases of Psoriasis[J].Western Journal of Traditional Chinese Medicine,2012,25(11):46.
[2]沈雷鸣,殷洁,刘元林△,等.消银汤对寻常型银屑病患者血清白介素18的影响[J].西部中医药,2014,27(01):20.
　SHEN Leiming,YIN Jie,LIU Yuanlin,et al.The Effects of XiaoYin Tang on Serum IL-18 of the Patients Suffering from Psoriasis[J].Western Journal of Traditional Chinese Medicine,2014,27(11):20.
[3]汪雪晴.解毒消银汤配合青黛散外敷治疗寻常型银屑病疗效观察[J].西部中医药,2014,27(03):100.
　WANG Xueqing.Curative Observation on Treating Psoriasis Vulgaris by JieDu XiaoYin Tang and QingDai Powder for External Use[J].Western Journal of Traditional Chinese Medicine,2014,27(11):100.
[4]张保恒.清肺凉血汤联合阿维A治疗寻常型银屑病36例[J].西部中医药,2014,27(10):106.
[5]吴爱萍,李湘君,张丽,等.银屑病相关危险因素的病例对照研究[J].西部中医药,2015,28(08):64.
[6]高军,任万明,指导：强志鹏.雷公藤多甙对银屑病患者NF-кB及细胞因子的影响[J].西部中医药,2013,26(09):26.
　GAO Jun,REN Wanming,Director: QIANG Zhipeng.Effects of Glucosidorum Tripterygii Tororum on NF-κB and Cytokines of Patients with Psoriasis[J].Western Journal of Traditional Chinese Medicine,2013,26(11):26.
[7]宋红霞,薛晓东△.消银汤对银屑病样模型小鼠TNF-α及IL-10的影响[J].西部中医药,2018,31(01):16.
　SONG Hongxia,XUE Xiaodong.Effects of XiaoYin Decoction on IL-10 and TNF-α of Psoriasis like Mice Model[J].Western Journal of Traditional Chinese Medicine,2018,31(11):16.
[8]薛晓东,宋红霞△.消银汤联合NB-UVB对寻常型银屑病血热证疗效及血清中Th1/Th2型细胞因子的影响[J].西部中医药,2018,31(01):86.
　XUE Xiaodong,SONG Hongxia.Clinical Effects of XiaoYin Decoction Combined with NB-UVB in Treating Psoriasis Vulgaris of Blood-heat Pattern and the Influence on Th1/Th2 Cytokine in the Serum[J].Western Journal of Traditional Chinese Medicine,2018,31(11):86.
[9]张伟.十皮饮联合卡泊三醇软膏治疗银屑病38例[J].西部中医药,2017,30(08):123.
　ZHANG Wei.ShiPi Drink Combined with Calcipotriol Cream in Treating 38 Patients with Psoriasis[J].Western Journal of Traditional Chinese Medicine,2017,30(11):123.
[10]武鑫,陈敬△.专利中药治疗银屑病的用药规律分析[J].西部中医药,2018,31(07):73.
　WU Xin,CHEN Jing.Analysis of Drug Use Laws of Treating Psoriasis by Patent Herbs[J].Western Journal of Traditional Chinese Medicine,2018,31(11):73.

备注/Memo

备注/Memo:
曹一钦（1991—），男，硕士学位。研究方向：皮肤病及性病的中西医结合诊治。国家自然科学基金（82160908）；国家重点研发计划“中医药现代化研究”重点专项课题（2018YFC1705301）；贵州省科学技术厅基金项目（黔科合LH字20167504号）。
更新日期/Last Update: 2022-11-15