[1]张迎春,何海艳,杨欣,等.PPIs联合半夏厚朴汤治疗胃食管反流病疗效与安全性Meta分析[J].西部中医药,2023,36(01):62-70.[doi:10.12174/j.issn.2096-9600.2023.01.16]
 ZHANG Yingchun,HE Haiyan,YANG Xin,et al.Meta-analysis of the Efficacy and the Safety of PPIs Combined with Banxia Houpo Tang in the Treatment of Gastroesophageal Reflux Disease[J].Western Journal of Traditional Chinese Medicine,2023,36(01):62-70.[doi:10.12174/j.issn.2096-9600.2023.01.16]
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PPIs联合半夏厚朴汤治疗胃食管反流病疗效与安全性Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年01期
页码:
62-70
栏目:
出版日期:
2023-01-15

文章信息/Info

Title:
Meta-analysis of the Efficacy and the Safety of PPIs Combined with Banxia Houpo Tang in the Treatment of Gastroesophageal Reflux Disease
作者:
张迎春, 何海艳, 杨欣, 朱惠萍, 黄雪, 孙宏文
南京中医药大学附属苏州市中医医院,江苏 苏州 215009
Author(s):
ZHANG Yingchun, HE Haiyan, YANG Xin, ZHU Huiping, HUANG Xue, SUN Hongwen
Suzhou Hospital of Traditional Chinese Medicine, Suzhou 215009, China
关键词:
胃食管反流病气郁痰阻质子泵抑制剂半夏厚朴汤Meta分析
Keywords:
gastroesophageal reflux diseasedepression and phlegm obstruction patternPPIsMeta-analysis
分类号:
R2-03
DOI:
10.12174/j.issn.2096-9600.2023.01.16
文献标志码:
A
摘要:
目的对质子泵抑制剂(proton pump inhibitors,PPIs)联合半夏厚朴汤治疗胃食管反流病(gastroesophageal reflux disease,GERD)的疗效和安全性进行系统评价。 方法检索中国知网、万方、维普、中国生物医学文献服务系统、中国临床试验注册中心、Web of Science、Cochrane Library、PubMed、Embase,文种限制为中文及英文,收集自建库至2020年4月的PPIs联合半夏厚朴汤治疗GERD的临床随机对照试验(RCTs)。根据纳入和排除标准筛选文献,提取资料后采用RevMan5.3软件进行疗效和安全性的Meta分析。 结果共纳入14篇文献,Meta分析结果显示:在临床疗效(P<0.00001,RR=1.23,95%CI[1,17,1.29])、内镜下有效率(P<0.00001,RR=1.21,95%CI[1,12,1.31])、不良反应发生率(P=0.03,RR=0.38,95%CI[0.15,0.92])、临床症状RDQ评分(WMD=-0.96,95%CI[-1.12,-0.80],P<0.00001)、GerdQ评分(WMD=-2.17,95%CI[-2.79,-1.56],P<0.00001)、食管括约肌静息压(WMD=3.57,95%CI[1,15,6.00],P=0.004)方面试验组均优于对照组,差异有统计学意义。 结论PPIs联合半夏厚朴汤治疗GERD的疗效及安全性较好,优于单纯PPIs等西药治疗,在改善患者症状、食管黏膜炎症方面具有一定优势。
Abstract:
ObjectiveTo systematically assess clinical efficacy and the safety of PPIs and Banxia Houpo Tang in the treatment of gastroesophageal reflux disease (GERD). MethodsRCTs on PPIs and Banxia Houpo Tang in treating GERD were retrieved from CNKI, Wanfang, VIP, SinoMed, Chinese clinical trial registry, Web of Science, Cochrane Library, PubMed and Embase, the language limit is Chinese and English, between database building time and April, 2020. The papers were screened according to the inclusion and exclusion criteria, after extracting the data, RevMan 5.3 software was used to conduct Meta-analysis of clinical efficacy and the safety. ResultsAltogether 14 papers were included, Meta analysis showed that clinical efficacy (P<0.00001, RR=1.23, 95%CI[1.17, 1.29]), endoscopic effective rate (P<0.00001, RR=1.21, 95%CI[1.12, 1.31]), the incidence of adverse reaction (P=0.03, RR=0.38, 95%CI[0.15, 0.92]), RDQ scores of clinical symptoms (WMD=-0.96, 95%CI[-1.12, -0.80], P<0.00001), GerdQ scores (WMD=-2.17, 95%CI[-2.79, -1.56], P<0.00001), and the resting pressure of esophageal sphincter (WMD=3.57, 95%CI[1.15, 6.00], P=0.004), the trial group was superior to the control group, and the difference had statistical meaning. ConclusionPPIs and Banxia Houpo Tang show better clinical efficacy and safety in the treatment of GERD, superior to these of Western medicine therapy of single PPIs, and it possesses certain advantages in improving the patients' symptoms and esophageal mucosal inflammation.

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备注/Memo

备注/Memo:
张迎春(1997—),女,硕士研究生。研究方向:胃食管反流病的中西医结合诊治。国家中医药管理局吴门医派杂病流派传承工作室第二批项目([2019]62);苏州市卫生计生委科技项目(LCZX201817)。
更新日期/Last Update: 2023-01-15