[1]刘欣,唐颖,王亚男,等.巴戟天寡糖联合帕罗西汀对老年抑郁症患者血清FGF-22及ACTH表达的影响[J].西部中医药,2024,37(01):128-131.[doi:10.12174/j.issn.2096-9600.2024.01.25]
　LIU Xin,TANG Ying,WANG Ya'nan,et al.Influence of Morinda Citrifolia Oligosaccharide Joined with Paroxetine on the Expressions of Serum FGF-22 and ACTH in Senile Patients with Depression[J].Western Journal of Traditional Chinese Medicine,2024,37(01):128-131.[doi:10.12174/j.issn.2096-9600.2024.01.25]
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巴戟天寡糖联合帕罗西汀对老年抑郁症患者血清FGF-22及ACTH表达的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年01期
页码:
128-131
栏目:
衷中参西
出版日期:
2024-01-15

文章信息/Info

Title:
Influence of Morinda Citrifolia Oligosaccharide Joined with Paroxetine on the Expressions of Serum FGF-22 and ACTH in Senile Patients with Depression
作者:
刘欣, 唐颖, 王亚男, 赵蕊, 崔璐莎
唐山市开滦精神卫生中心，河北 唐山 063000
Author(s):
LIU Xin, TANG Ying, WANG Ya'nan, ZHAO Rui, CUI Lusha
Tangshan Kailuan Mental Health Center, Tangshan 063000, China
关键词:
抑郁症; 成纤维细胞生长因子22; 促肾上腺皮质激素; 巴戟天寡糖; 帕罗西汀
Keywords:
depression; FGF-22; ACTH; morinda citrifolia oligosaccharide; paroxetine
分类号:
R277.7
DOI:
10.12174/j.issn.2096-9600.2024.01.25
文献标志码:
B
摘要:
目的研究巴戟天寡糖联合帕罗西汀对老年抑郁症患者血清成纤维细胞生长因子22（fibroblast growth factor-22，FGF-22）以及促肾上腺皮质激素（adrenocorticotropic hormone，ACTH）表达的影响。 方法将160例老年抑郁症患者随机分为对照组和研究组各80例，对照组患者每日口服帕罗西汀20 mg，研究组在对照组基础上口服巴戟天寡糖胶囊，每次0.3 g，每天2次。治疗6周后评估两组患者临床疗效；分别于治疗前及治疗后采用汉密尔顿焦虑自评量表（Hamilton anxiety scale，HAMA）评价患者焦虑状态，采用汉密尔顿抑郁量表（Hamilton depression scale，HAMD）评价患者抑郁状态，采用酶联免疫吸附法测定患者血清白细胞介素1β（interleukin-1β，IL-1β）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）、FGF-22以及ACTH表达水平；观察两组患者治疗期间不良反应发生情况。 结果研究组总有效率为90.00%（72/80），高于对照组的65.00%（52/80）（P＜0.05）。治疗后两组患者HAMA及HAMD评分均较治疗前降低，研究组低于对照组（P＜0.05）。治疗后两组患者血清IL-1β和TNF-α水平均较治疗前降低，研究组低于对照组（P＜0.05）。治疗后两组患者血清FGF-22水平均较治疗前升高，ACTH水平均较治疗前降低，研究组改善更明显（P＜0.05）。研究组不良反应发生率为3.75%，低于对照组的12.50%（P＜0.05）。 结论巴戟天寡糖联合帕罗西汀可以改善抑郁症患者抑郁及焦虑状态，降低炎性因子IL-1β、TNF-α及血清ACTH水平，提高FGF-22水平，效果优于单用帕罗西汀，且不良反应发生率低。
Abstract:
ObjectiveTo study the effects of morinda citrifolia oligosaccharide and paroxetine on the expressions of serum FGF-22 and ACTH in patients with depression. MethodsAll 160 patients were randomized into the control group and the study group with 80 cases in each group, the control group took paroxetine orally, 20 mg each day, and the study group morinda citrifolia oligosaccharide capsules based on Western medicine the control group accepted, 0.3 g each time，twice each day. To assess clinical effects after six weeks of treatment; to assess the patients' anxiety using HAMA respectively before and after treatment，to evaluate the patients' depression using HAMD, to detect the levels of IL-1β, TNF-α, FGF-22 and ACTH using ELISA; to observe the patients' incidence of adverse reaction during therapeutic period between both groups. ResultsTotal effective rate of the study group was 90.00%（72/80）, higher than 65.00%（52/80） of the control group (P<0.05).HAMD and HAMA of both groups were lowered after treatment than these before treatment，the study group was lower than the control group (P<0.05).After the treatment, the levels of IL-1β and TNF-α were decreased than these before the treatment，the study group was lower than the control group (P<0.05).After the treatment，the levels of FGF-22 were higher than these before the treatment in both groups，the levels of ACTH were lower than these before the treatment，the improvements of the study group were more noticeable (P<0.05).The incidence of adverse reaction of the study group was 3.75%, lower than 12.50% of the control group (P<0.05). ConclusionMorinda citrifolia oligosaccharide and paroxetine could improve anxiety and depression，reduce the levels of inflammatory factors such as IL-1β and TNF-α and serum ACTH, raise the levels of FGF-22, and its effects are superior to these of paroxetine with low adverse reactions..

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备注/Memo

备注/Memo:
刘欣（1982—），女，主管护师。研究方向：精神疾病的护理。E-mail：zjkfvu344yu98@163.com。河北省医学科学研究课题计划项目（20191324）。
更新日期/Last Update: 2024-01-15