[1]韩宇潇,李孟,谢春郁.旭痹舒汤联合来氟米特治疗寒湿痹阻型类风湿关节炎疗效观察[J].西部中医药,2024,37(01):145-149.[doi:10.12174/j.issn.2096-9600.2024.01.29]
　HAN Yuxiao,LI Meng,XIE Chunyu.Observation on Effects of Xubishu Tang Combined with Leflunomide in the Treatment of Rheumatoid Arthritis of Cold Dampness Obstruction Pattern[J].Western Journal of Traditional Chinese Medicine,2024,37(01):145-149.[doi:10.12174/j.issn.2096-9600.2024.01.29]
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旭痹舒汤联合来氟米特治疗寒湿痹阻型类风湿关节炎疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年01期
页码:
145-149
栏目:
衷中参西
出版日期:
2024-01-15

文章信息/Info

Title:
Observation on Effects of Xubishu Tang Combined with Leflunomide in the Treatment of Rheumatoid Arthritis of Cold Dampness Obstruction Pattern
作者:
韩宇潇, 李孟, 谢春郁
黑龙江中医药大学附属第一医院/黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨 150040
Author(s):
HAN Yuxiao, LI Meng, XIE Chunyu
First Affiliated Hospital/First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China
关键词:
类风湿关节炎; 寒湿痹阻型; 血沉; 类风湿因子; C反应蛋白; 旭痹舒汤; 来氟米特
Keywords:
rheumatoid arthritis; cold dampness obstruction pattern; erythrocyte sedimentation rate; rheumatoid factors; CRP; leflunomide
分类号:
R274.9
DOI:
10.12174/j.issn.2096-9600.2024.01.29
文献标志码:
B
摘要:
目的观察旭痹舒汤联合来氟米特治疗寒湿痹阻型类风湿性关节炎（rheumatoid arthritis，RA）的临床疗效。 方法将120例寒湿痹阻型RA患者经随机数字表法分为观察组和对照组各60例，对照组予来氟米特治疗，观察组予旭痹舒汤联合来氟米特治疗，比较两组患者临床疗效、主要症状与体征情况、体液免疫指标［血沉（erythrocyte sedimentation rate，ESR）、类风湿因子（rheumatoid factor，RF）、C反应蛋白（C-reaction protein，CRP）及免疫球蛋白G（immunoglobulin G，IgG）］、世界卫生组织生活质量测定量表简表（WHOQOL-BREF）评分及不良反应发生情况。 结果观察组总有效率为91.67%（55/60），高于对照组的76.67%（46/60）（P＜0.05）；治疗后观察组患者休息痛评分、晨僵时间、关节肿胀数、关节压痛数低于对照组，双手平均握力高于对照组（P＜0.05）；治疗后观察组ESR、RF、CRP、IgG水平低于对照组（P＜0.05）；治疗后观察组WHOQOL-BREF中周围环境、生理健康、社会关系、心理健康4个领域评分高于对照组（P＜0.05）；观察组不良反应发生率为6.67%（4/60），低于对照组的21.67%（13/60）（P＜0.05）。 结论旭痹舒汤联合来氟米特能够改善寒湿痹阻型RA患者临床症状、体征以及体液免疫指标，有利于提高患者临床疗效及生活质量，并且不良反应发生率低。
Abstract:
ObjectiveTo discuss clinical effects of Xubishu Tang and leflunomide in the treatment of rheumatoid arthritis(RA) of cold dampness obstruction pattern. MethodsAll 120 RA patients were separated into the observation group and the control group using random number table method, the control group was treated by leflunomide, and the observation group by Xubishu Tang and leflunomide, to compare clinical effects, main symptoms and body signs, the indicators of humoral immunity including ESR, RF, CRP and IgG, WHOQOL scores and the incidences of adverse reaction between both groups. ResultsTotal effective rate of the observation group was 91.67%（55/60）, higher than 76.67%（46/60） of the control group (P<0.05); after the treatment, rest pain score, morning stiffness time, number of swollen joints and number of joint tenderness of the observation group were lower than these of the control group, average grip strength of both hands higher than that of the control group (P<0.05); after the treatment，the levels of ESR, RF, CRP and IgG of the observation group were lower than these of the control group (P<0.05); after the treatment, the scores of surroundings, physical health, social relationships, mental health of WHOQOL-BREF of the observation group were higher than these of the control group (P<0.05); the incidence of adverse reaction of the observation group was 6.67%（4/60）, lower than 21.67%（13/60） of the control group (P<0.05). ConclusionCompared with single use of leflunomide, its combination with Xubishu Tang could obviously improve clinical symptoms, body signs and the indicators of humoral immunity in RA patients, help improve the patients' clinical effects and quality of life, with low incidence of adverse reaction.

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备注/Memo

备注/Memo:
韩宇潇（1980—），女，硕士学位，主治医师。研究方向：风湿病的中西医结合治疗。E-mail：huligege745@163.com。黑龙江省中医药科研项目（XHY18-056）。
更新日期/Last Update: 2024-01-15