[1]周黎黎,柳春玲,沈玉鹏,等.运脾颗粒对幼龄厌食模型大鼠胃肠激素水平的影响[J].西部中医药,2017,30(03):12-15.
　ZHOU Lili,LIU Chunling,SHEN Yupeng,et al.Effect of YunPi Granule on Gastrointestinal Hormone Levels in Juvenile Anorexia Rat Models[J].Western Journal of Traditional Chinese Medicine,2017,30(03):12-15.
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运脾颗粒对幼龄厌食模型大鼠胃肠激素水平的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年03期
页码:
12-15
栏目:
出版日期:
2017-03-15

文章信息/Info

Title:
Effect of YunPi Granule on Gastrointestinal Hormone Levels in Juvenile Anorexia Rat Models
文章编号:
1004-6852(2017)03-0012-04
作者:
周黎黎1，柳春玲2，沈玉鹏1，牛亭惠3，杜丽东3，4' target="_blank" rel="external">4，吴国泰3，4' target="_blank" rel="external">4
1 甘肃省中医院，甘肃 兰州 730050； 2 兰州市中医医院；3 甘肃中医药大学； 4 甘肃省中药药理与毒理学重点实验室
Author(s):
ZHOU Lili1, LIU Chunling2, SHEN Yupeng1, NIU Tinghui 3, DU Lidong 3,4' target="_blank" rel="external">4, WU Guotai 3,4' target="_blank" rel="external">4
1 Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Lanzhou Municipality TCM Hospital; 3 Gansu University of Traditional Chinese Medicine; 4 Gansu Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine
关键词:
厌食; 运脾颗粒; 胃肠激素水平
Keywords:
anorexia;  YunPi granules;  gastrointestinal hormone level
分类号:
R442
文献标志码:
A
摘要:
目的：探讨运脾颗粒对幼龄厌食模型大鼠胃肠激素水平和小肠吸收功能的影响。方法：将60只SD幼龄大鼠随机分为正常对照组、模型对照组、阳性对照组(儿宝颗粒，1.75g/kg)、运脾颗粒高、中、低剂量组(4.20、2.10、1.05 g/kg)，每组10只，采用特制高脂饲料喂养建立厌食症大鼠模型，造模和给药期间监测大鼠的体质量和摄食量，采用ELISA法测定各组大鼠血清胃泌素(GAS)及生长抑素(SS)含量，取胃窦部胃壁组织，制备组织匀浆，ELISA法测定胃窦GAS及SS含量。结果：造模后大鼠体质量和24小时摄食量明显减少，血清和胃窦GAS含量明显降低、SS含量明显升高(P＜0.05)；给药后，运脾颗粒不同剂量组大鼠体质量和24小时摄食量均有不同程度的增加，高、中剂量组血清GAS均升高，胃窦GAS升高，胃窦SS降低(P＜0.05)。结论：运脾颗粒对幼龄厌食模型大鼠胃肠激素水平具有一定的调节作用。
Abstract:
Objective: To explore the effect of YunPi granule on gastrointestinal hormone and intestinal absorption function of juvenile anorexia rat models. Methods: All 60 SD young rats were randomly divided into normal control group, model control group, positive control group (Erbao granule, 1.75 g/kg), high-dose group of YunPi granule (4.20 g/kg), middle-dose group of YunPi granule (2.10 g/kg), and low-dose group of YunPi granule (1.05 g/kg) with ten rats in each group. Rat model with anorexia was established by feeding special high fat diet. The body weight and food intake were monitored during the course of modeling and administration. The serum GAS and SS contents were determined by ELISA method. At the same time, antral gastric tissue was taken, and tissue homogenate was prepared. Antral GAS and SS contents were determined by ELISA method. Results: After modeling, the body weight and the 24-hour feeding amounts of rats significantly reduced. GAS contents of serum and gastric antrum remarkably decreased. Moreover, the content of SS obviously increased (P＜0.05); After administration, the body weight and the 24-hour feeding amounts of rats in different dosage groups increased in different degrees. The levels of the serum GAS and the GAS of gastric antrum in the high and middle dose groups increased, and SS contents of gastric antrum decreased (P＜0.05). Conclusion: YunPi granule has a regulatory effect on gastrointestinal hormone levels in juvenile anorexia rat models.

相似文献/References:

[1]周黎黎,任耀全,柳春玲.运脾颗粒治疗脾虚型小儿厌食的临床观察[J].西部中医药,2015,28(03):110.
[2]柳春玲,周黎黎,牛亭惠,等.运脾颗粒对幼龄厌食模型大鼠消化功能的影响[J].西部中医药,2016,29(02):9.
　LIU Chunling,ZHOU Lili,NIU Tinghui,et al.Influence of YunPi Granules on Digestive Function of Juvenile Rats with Anorexia[J].Western Journal of Traditional Chinese Medicine,2016,29(03):9.
[3]马国珍,舒劲,王煜,等.运脾颗粒对功能性消化不良大鼠胃肠激素的影响[J].西部中医药,2018,31(04):20.
　MA Guozhen,SHU Jin,WANG Yu,et al.Effects of Spleen-activating Granules on Gastrointestinal Hormone of the Rats with Functional Dyspepsia[J].Western Journal of Traditional Chinese Medicine,2018,31(03):20.
[4]陈燕云,李初谊,李竞.运脾颗粒对功能性消化不良小鼠胃肠运动和胃泌素、抑胃肽的影响[J].西部中医药,2021,34(07):44.[doi:10.12174/j.issn.2096-9600.2021.07.10]
　CHEN Yanyun,LI Chuyi,LI Jing.Effects of Spleen-activating Granules on Gastrointestinal Motility, Gastrin, Gastric Inhibitory Polypeptide in the Mice with Functional Dyspepsia[J].Western Journal of Traditional Chinese Medicine,2021,34(03):44.[doi:10.12174/j.issn.2096-9600.2021.07.10]

备注/Memo

备注/Memo:
收稿日期：2016-07-15 *基金项目：甘肃省中医药管理局科研立项课题(编号GZK-2014-28)。 作者简介：周黎黎(1983—)，女，硕士学位，主治医师。研究方向：儿科常见病的中医诊治。
更新日期/Last Update: 2017-03-15