[1]席晓蓉,程羽,羊忠山,等.玉屏风散加味方中“涤痰”“逐瘀”作用药对对COPD大鼠肺组织TGF-β1/Smad通路的影响[J].西部中医药,2018,31(03):9-11.
　XI Xiaorong,CHENG Yu,YANG Zhongshan,et al.The Influence of Couplet Medicines of ″Washing Away the Phlegm″ and ″Expelling the Stasis″ in Modified YuPingFeng Powder on TGF-β1/Smad Pathway in Lung Tissue of COPD Rat Model[J].Western Journal of Traditional Chinese Medicine,2018,31(03):9-11.
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玉屏风散加味方中“涤痰”“逐瘀”作用药对对COPD大鼠肺组织TGF-β1/Smad通路的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年03期
页码:
9-11
栏目:
出版日期:
2018-03-15

文章信息/Info

Title:
The Influence of Couplet Medicines of ″Washing Away the Phlegm″ and ″Expelling the Stasis″ in Modified YuPingFeng Powder on TGF-β1/Smad Pathway in Lung Tissue of COPD Rat Model
文章编号:
1004-6852(2018)03-0009-03
作者:
席晓蓉，程羽，羊忠山，赵文娟，潘晶晶，袁嘉丽△
云南中医学院，云南 昆明 650500
Author(s):
XI Xiaorong, CHENG Yu, YANG Zhongshan, ZHAO Wenjuan, PAN Jingjing, YUAN Jiali△
Yunnan University of TCM, Kunming 650500, China
关键词:
慢性阻塞性肺疾病; TGF-β1/Smad信号转导通路; 玉屏风散加味方; “涤痰”; “逐瘀”; 药对
Keywords:
COPD;  TGF-β1/Smad signal transduction pathway;  modified YuPingFeng powder;  "washing away the phlegm";  "expelling the stasis";  couplet medicines
分类号:
R285
摘要:
目的：探讨玉屏风散加味方中“涤痰”和“逐瘀”作用药对对慢性阻塞性肺疾病（COPD）大鼠TGF-β1/Smad信号转导通路的影响。方法：将雄性SPF级Wistar大鼠90只随机分为正常组、模型组、罗红霉素组及“涤痰”作用药对高、中、低剂量组和“逐瘀”作用药对高、中、低剂量组。采用酶联免疫吸附试验(ELISA)检测大鼠转化生长因子β1(TGF-β1)，采用蛋白质印迹法(Western blot)检测大鼠肺组织Smad2/3、Smad7表达水平。结果：“涤痰”作用药对和“逐瘀”作用药对低、中剂量组及罗红霉素组TGF-β1表达水平较模型组降低；“涤痰”作用药对低剂量组Smad2/3水平低于模型组；“涤痰”作用药对高剂量组和“逐瘀”作用药对各剂量组Smad7水平高于模型组。结论：玉屏风散加味方中“涤痰”和“逐瘀”作用药对对COPD大鼠TGF-β1/Smad信号转导通路有调节作用。
Abstract:
Objective: To discuss the influence of couplet medicines of "washing away the phlegm" and "expelling the stasis" in modified YuPingFeng powder on TGF-β1/Smad signal transduction pathway in lung tissue of COPD rat model. Methods: Ninety Wistar male SPF rats were randomized into the normal group, the model group, roxithromycin group, high, moderate and low dose groups of couplet medicines of "washing away the phlegm" as well as high, moderate and low dose groups of couplet medicines of "expelling the stasis". The expressions of Smad2/3 and Smad7 in lung tissue of the rats were detected by Western blot, and the expression of TGF-β1 by ELISA method. Results: The expression of TGF-β1 in moderate and low dose groups of couplet medicines of "washing away the phlegm" and "expelling the stasis" and roxithromycin group was lower compared with the model group; low dose group of couplet medicines of "washing away the phlegm" was lower than the model group in the expressions of Smad2/3, high dose group of couplet medicines of "washing away the phlegm" and different doses groups of couplet medicines of "expelling the stasis" were higher than the model group in the levels of Smad7.Conclusion: Couplet medicines of "washing away the phlegm" and "expelling the stasis" in modified YuPingFeng powder could regulate TGF-β1/Smad signal transduction pathway in lung tissue of COPD rat model.

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备注/Memo

备注/Memo:
收稿日期：2017-05-10 *基金项目：国家自然科学基金项目(编号81460684)；云南省教育厅重大项目(编号2014Z121)。 作者简介：席晓蓉(1978—)，女，硕士学位，副教授。研究方向：中西医结合基础。 △通讯作者：袁嘉丽(1963—)，女，博士学位，教授。研究方向：中医药调节免疫及微生态平衡防治感染性疾病应用基础研究。
更新日期/Last Update: 2018-03-15