[1]解静,代二庆△.胃萎Ⅰ号冲剂治疗慢性萎缩性胃炎155例[J].西部中医药,2019,32(04):88-90.
　XIE Jing,DAI Erqing.Treating 155 Cases of Chronic Atrophic Gastritis with the Granules WeiWei No.1[J].Western Journal of Traditional Chinese Medicine,2019,32(04):88-90.
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胃萎Ⅰ号冲剂治疗慢性萎缩性胃炎155例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年04期
页码:
88-90
栏目:
出版日期:
2019-04-15

文章信息/Info

Title:
Treating 155 Cases of Chronic Atrophic Gastritis with the Granules WeiWei No.1
文章编号:
1004-6852(2019)04-0088-03
作者:
解静，代二庆△
中国人民武装警察部队后勤学院附属医院，天津 300162
Author(s):
XIE Jing, DAI Erqing△
Affiliated Hospital of Logistics University of Chinese People′s Armed Police Forces, Tianjin 300162, China
关键词:
胃炎; 萎缩性; 慢性; 胃萎Ⅰ号冲剂; 幽门螺杆菌
Keywords:
gastritis;  atrophic;  chronic;  the granules WeiWei No.1;  Hp
分类号:
R573.3+2
文献标志码:
B
摘要:
目的：观察胃萎Ⅰ号冲剂治疗慢性萎缩性胃炎(CAG)的临床疗效。方法：将155例患者随机分为观察组(105例)和对照组(50例）。观察组服用胃萎Ⅰ号冲剂，5 g/次，3次/d；对照组服用三九胃泰冲剂，20 g/次，3次/d。2组均以治疗3个月为1个疗程，治疗期间停用其他相关治疗药物。观察2组治疗后症状改善情况，Hp转阴率，病理组织学改善程度及临床疗效。结果：2组胃脘痛、吞酸、嗳气、大便异常、纳呆有效率比较，差异有统计学意义(P＜0.05)；余无统计学意义(P＞0.05)。Hp转阴率2组比较，差异有统计学意义(P＜0.05)。观察组4证型间Hp转阴率差异无统计学意义(P＞0.05)。胃黏膜萎缩、肠上皮化生和不典型增生等病理改善有效率2组比较，差异均有统计学意义(P＜0.05)。观察组临床总有效率98%；对照组临床总有效率86%。2组比较，差异有统计学意义(P＜0.05)；观察组各证型间比较，差异无统计学意义(P＞0.05)。结论：复方中药胃萎Ⅰ号冲剂能够有效改善CAG患者的临床症状，对清除Hp及改善病理有一定的临床作用。
Abstract:
Objective: To observe clinical effects of the granules WeiWei No.1 in the treatment for chronic atrophic gastritis (CAG). Methods: A total of 155 patients were randomized into 105 cases of the observation group and 50 cases of the control group, the observation group took the granules WeiWei No.1, 5 g each time, three times each day, and the control group took SanJiu WeiTai granules, 20 g each time, three times each day, three months were one course, no therapy-related herbs were given during therapeutic period. To observe the improvement of the symptoms, Hp negative-conversion rate, the improvements of pathological tissue and clinical effects in both groups after treating. Results: The difference had statistical meaning in the effective rates of epigastralgia, acid regurgitation, belching, abnormal stool and anorexia (P＜0.05); and no difference had been found in the other indexes (P＞0.05). The difference had statistical meaning in the comparisons of Hp negative-conversion rates between both groups (P＜0.05). No obvious difference had been found in the comparisons of Hp negative-conversion rates among four patterns in the observation group(P＞0.05). The difference had statistical meaning in the comparisons of the effective rates of gastric mucosal atrophy, intestinal metaplasia, atypical hyperplasia between both groups(P＜0.05). Total effective rate of the observation group, was 98%, higher than 86% of the control group. The difference had statistical meaning in the comparisons between both groups(P＜0.05); the difference had no statistical meaning in the comparisons of different patters in the observation group(P＞0.05). Conclusion: Compound herbs the granules WeiWei No.1 could effectively improve clinical symptoms of CAG patients, which shows certain clinical effects on eliminating Hp and improving the pathology.

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备注/Memo

备注/Memo:
收稿日期：2018-07-22 *基金项目：国家自然科学基金资助项目(编号81273745)；天津市自然科学基金资助项目(编号11JCYBJC10900)。 作者简介：解静(1989—)，女，在读博士研究生。研究方向：消化系统疾病的中西医结合诊治。 △通讯作者：代二庆(1969—)，男，主任医师。研究方向：消化系统疾病的中西医结合诊治及实验研究。
更新日期/Last Update: 2019-04-15