[1]王准.通脉舒络汤治疗老年冠心病的临床观察[J].西部中医药,2020,33(06):81-84.[doi:10.12174/j.issn.1004-6852.2020.06.21]
　WANG Zhun.Observation on Clinical Effects of Tongmai Shuluo Tang in Treating Coronary Atherosclerotic Heart Disease in the Elderly[J].Western Journal of Traditional Chinese Medicine,2020,33(06):81-84.[doi:10.12174/j.issn.1004-6852.2020.06.21]
点击复制

通脉舒络汤治疗老年冠心病的临床观察
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年06期
页码:
81-84
栏目:
出版日期:
2020-06-15

文章信息/Info

Title:
Observation on Clinical Effects of Tongmai Shuluo Tang in Treating Coronary Atherosclerotic Heart Disease in the Elderly
文章编号:
1004-6852(2020)06-0081-04
作者:
王准
应城市人民医院药事管理科，湖北 应城 432400
Author(s):
WANG Zhun
Pharmacy Administration Department, Yingcheng City People′s Hospital, Yingcheng 432400, China
关键词:
冠心病; 动脉粥样硬化; 通脉舒络汤; 颈动脉内-中膜厚度; 机制
Keywords:
coronary heart disease;  atherosclerosis;  Tongmai Shuluo Tang;  carotid intima-media thickness; the mechanism
分类号:
R541.4
DOI:
10.12174/j.issn.1004-6852.2020.06.21
文献标志码:
B
摘要:
目的：探讨通脉舒络汤治疗气虚血瘀兼夹痰瘀证老年冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart，CHD)的临床疗效及作用机制。方法：将88例患者随机分为对照组和观察组，每组44例。对照组给予常规治疗，观察组在对照组基础上给予通脉舒络汤治疗，两组均以治疗4周为1个疗程，治疗2个疗程后评估临床疗效，测定一氧化氮(nitric oxide，NO)、血浆内皮素1(endothelin-1，ET-1)、丙二醛(malonaldehyde,MDA)、过氧化物歧化酶(superoxide dismutase，SOD)，颈动脉超声检测颈动脉内-中膜厚度(intima-media thickness，IMT)及斑块面积。结果：总有效率观察组为86.36%（38/44），对照组为68.18%（30/44），两组比较差异有统计学意义(P＜0.05)。NO、ET-1、MDA、SOD、IMT及斑块面积治疗前后两组组内比较，差异有统计学意义(P＜0.05)。药物不良反应发生率观察组为11.36%（5/44），对照组为9.09%（4/44），两组比较差异无统计学意义(P＞0.05)。结论：通脉舒络汤治疗气虚血瘀兼夹痰瘀证老年CHD，可减小IMT和斑块面积，可能与减轻氧化应激损伤、改善内皮功能障碍有关。
Abstract:
Objective: To explore clinical effects of Tongmai Shuluo Tang in treating the elderly with CHD of Qi-deficiency blood-stasis phlegm-stagnation pattern and study its mechanism. Methods: All 88 patients were randomized into the control group and the observation group, 44 cases each group. The control group accepted conventional therapy, and the observation group Tongmai Shuluo Tang, four weeks were one course, after treating for two courses, to assess clinical effects, detect NO, ET-1, MDA and SOD, to measure IMT and plaque area using carotid ultrasound. Results: Total effective rate of the observation group was 86.36% (38/44), higher than 68.18% (30/44) of the control group, and the difference had statistical meaning between both groups (P＜0.05). The difference was statistically significant in NO, ET-1, MDA, SOD, IMT and plaque area before and after treating between both groups (P＜0.05). The incidence of adverse drug reaction of the observation group was 11.36% (5/44), higher than 9.09% (4/44) of the control group, and the difference had no statistical meaning between both groups (P＞0.05). Conclusion: Tongmai Shuluo Tang in treating the elderly with CHD of Qi-deficiency blood-stasis phlegm-stagnation pattern could reduce IMT plaquearea, and it might be related to oxidative stress injury reduction and improving endothelial dysfunction.

相似文献/References:

[1]朱晓娜,李天浩.调脂柔脉颗粒治疗动脉粥样硬化性脑梗死的疗效评价[J].西部中医药,2012,25(10):77.
　ZHU Xiao-na,LI Tian-hao.Evaluation on Clinical Efficacy of TiaoZhi RouMai Granules in Treating Atherosclerotic Cerebral Infarction[J].Western Journal of Traditional Chinese Medicine,2012,25(06):77.
[2]马思清 指导：谢春毅.瓜蒌薤白三方防治冠心病的研究现状[J].西部中医药,2012,25(10):118.
　MA Si-qing Director: XIE Chun-yi.Exploration on Three Pieces of GuaLou XieBaiFang in the Prevention of Coronary Heart Disease[J].Western Journal of Traditional Chinese Medicine,2012,25(06):118.
[3]马乔娟.银杏叶提取物对绝经后冠心病妇女冠脉血流及血管弹性的影响[J].西部中医药,2013,26(02):24.
　MA Qiaojuan.Effects of Ginaton on Coronary Blood Flow and Vascular Elasticity of Postmenopausal Women with Coronary Heart Disease[J].Western Journal of Traditional Chinese Medicine,2013,26(06):24.
[4]东红.中风膏对动脉粥样硬化模型家兔血脂水平、血管内皮功能的影响*[J].西部中医药,2013,26(03):25.
　DONG Hong.Effects of ZhongFengGao on Level of Blood Fat and Vascular Endothelial Function of Rabbits with Atherosclerosis[J].Western Journal of Traditional Chinese Medicine,2013,26(06):25.
[5]王龙,王化良.王化良主任巧用经方治疗冠心病合并焦虑状态经验浅析[J].西部中医药,2013,26(03):39.
　WANG Long,WANG Hualiang.Analysis on Director WA NG Hualiang's Experience of Applying Classic Prescriptions to Coronary Heart Disease Complicated to Anxiety[J].Western Journal of Traditional Chinese Medicine,2013,26(06):39.
[6]马丽.冠心病二级预防用药出院带药情况分析[J].西部中医药,2013,26(07):58.
　MA Li.Analysis on Prescribed Medications for Discharged Patients in Secondary Prevention of Coronary Heart Disease[J].Western Journal of Traditional Chinese Medicine,2013,26(06):58.
[7]潘雪晖.综合护理干预对冠心病患者不良生活方式的影响[J].西部中医药,2013,26(07):105.
　PAN Xuehui.Impact of Comprehensive Nursing Intervention on Lifestyles of Patients with Coronary Heart Disease[J].Western Journal of Traditional Chinese Medicine,2013,26(06):105.
[8]袁春玲.家庭病床冠心病护理可行性探讨[J].西部中医药,2012,25(07):109.
　YUAN Chun-ling.Probe into Feasibility of Nursing for Patients with Coronary Heart Disease in Family Practice[J].Western Journal of Traditional Chinese Medicine,2012,25(06):109.
[9]王凯,林文.丹红与丹参酮ⅡA治疗冠心病心绞痛疗效比较[J].西部中医药,2013,26(08):88.
　WANG Kai,LIN Wen.Comparison between DanHong Injection and Tanshinone ⅡA in Treating Angina Pectoris of Patients with Coronary Heart Disease[J].Western Journal of Traditional Chinese Medicine,2013,26(06):88.
[10]董瑞萍.阿昔莫斯胶囊对冠心病PCI术后血液流变学及血脂的调节作用[J].西部中医药,2012,25(05):6.
　DONG Rui-ping.Adjustment of Acipimox Capsule on Hemorheology and Blood Lipid in Patients after PCI[J].Western Journal of Traditional Chinese Medicine,2012,25(06):6.

备注/Memo

备注/Memo:
收稿日期：2019-07-08*基金项目：武汉市科技计划项目［2(10951999575)］。作者简介：王准(1980—)，男，主管药师。研究方向：药学。
更新日期/Last Update: 2020-06-15