[1]杨开银,薛建军,梁曦,等.甘草喷雾剂预防全麻气管插管应激反应及术后并发症临床观察[J].西部中医药,2021,34(09):103-107.[doi:10.12174/j.issn.2096-9600.2021.09.28]
　YANG Kaiyin,XUE Jianjun,LIANG Xi,et al.Clinical Observation on Licorice Spray in the Prevention of Stress Response of Endotracheal Intubation Under General Anesthesia and Postoperative Complications[J].Western Journal of Traditional Chinese Medicine,2021,34(09):103-107.[doi:10.12174/j.issn.2096-9600.2021.09.28]
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甘草喷雾剂预防全麻气管插管应激反应及术后并发症临床观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年09期
页码:
103-107
栏目:
衷中参西
出版日期:
2021-09-15

文章信息/Info

Title:
Clinical Observation on Licorice Spray in the Prevention of Stress Response of Endotracheal Intubation Under General Anesthesia and Postoperative Complications
作者:
杨开银, 薛建军, 梁曦, 张杰, 李文娟, 张凌云
甘肃省中医院麻醉科，甘肃 兰州 730050
Author(s):
YANG Kaiyin, XUE Jianjun, LIANG Xi, ZHANG Jie, LI Wenjuan, ZHANG Lingyun
Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
应激反应; 术后并发症; 气管插管; 甘草喷雾剂; 利多卡因
Keywords:
stress response; postoperative complications; endotracheal intubation; licorice spray; lidocaine
分类号:
R473
DOI:
10.12174/j.issn.2096-9600.2021.09.28
摘要:
目的观察甘草喷雾剂预防全麻气管插管应激反应及术后并发症的临床效果。 方法将行腹腔镜胆囊切除术住院且全麻气管插管患者300例随机分为生理盐水组、利多卡因组和甘草喷雾剂组各100例。3组分别于气管插管前10 min将0.9%生理盐水、2%利多卡因及甘草喷雾剂各2 mL，分别喷入患者口腔，充分浸润咽喉部位；3组诱导方案、麻醉维持和呼吸机参数设置相同。观察3组患者气管插管应激反应及术后并发症。 结果利多卡因组和甘草喷雾剂组在插管即刻(T2)、插管后1 min(T3)、3 min(T4)、5 min(T5)各时间点收缩压（systolic blood pressure，SBP）、舒张压（diastolic blood pressure，DBP）、心率（heart rate，HR）值和血浆去甲肾上腺素（norepinephrine，NE）、肾上腺素（epinephrine，E）浓度均低于生理盐水组（P＜0.05）；利多卡因组和甘草喷雾剂组患者各时间点咽痛和声嘶发生率低于生理盐水组（P＜0.05）；甘草喷雾剂组在T2和T3各时间点咽痛和声嘶发生率低于利多卡因组（P＜0.05）；利多卡因组和甘草喷雾剂组呛咳发生率和躁动发生率低于生理盐水组（P＜0.05）；各时间点血清白细胞介素1(interleukin-1，IL-1)、IL-6和IL-8水平利多卡因组和甘草喷雾剂组低于生理盐水组（P＜0.05），甘草喷雾剂组低于利多卡因组（P＜0.05）。 结论甘草喷雾剂可减轻全麻气管插管应激反应和术后并发症。
Abstract:
ObjectiveTo observe clinical effects of licorice spray in the prevention of stress response of endotracheal intubation under general anesthesia and postoperative complications. MethodsAll 300 patients who accepted laparoscopic cholecystectomy and endotracheal intubation under general anesthesia were randomized into physiological saline group, lidocaine group and licorice spray group, 100 cases in each group. All 0.9% physiological saline, 2% lidocaine and licorice spray were sprayed into the mouth to infiltrate the throat competely ten minutes before endotracheal intubation in three groups respectively; induction scheme, anesthesia maintenance and ventilator parameter setting were same in three groups. To observe stress response of endotracheal intubation under general anesthesia and postoperative complications in three groups. ResultsSBP, DBP and HR and the concentrations of NE and E at T2, T3, T4 and T5 of lidocaine group and licorice spray group were lower than these of physiological saline group (P<0.05); the incidence of sore throat and hoarseness at different time in lidocaine group and licorice spray group were lower than these of physiological saline group (P<0.05); the incidences of sore throat and hoarseness at T2 and T3 in licorice spray group were notably lower than these of lidocaine group (P<0.05); the incidences of choking cough and dysphoria in lidocaine group and licorice spray group were lower than these of physiological saline group (P<0.05); the levels of IL-1, IL-6 and IL-8 at different times in lidocaine group and licorice spray group were lower than these of physiological saline group (P<0.05), licorice spray group was lower than lidocaine group (P<0.05). ConclusionLicorice spray could relieve stress response of endotracheal intubation under general anesthesia and postoperative complications.

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备注/Memo

备注/Memo:
杨开银（1979—），男，硕士学位，主治医师。研究方向：临床麻醉与器官保护。甘肃省中医药管理局科研课题（GZK-2017-30）。
更新日期/Last Update: 2021-09-15