[1]姜小帆,李娟娥,吉海旺,等.类风湿关节炎血瘀证素量化诊断标准探索性研究[J].西部中医药,2021,34(09):138-142.[doi:10.12174/j.issn.2096-9600.2021.09.38]
　JIANG Xiaofan,LI Juane,JI Haiwang,et al.Exploratory Study on Quantitative Diagnostic Criteria for Syndrome Elements of Rheumatoid Arthritis of Blood Stasis Pattern[J].Western Journal of Traditional Chinese Medicine,2021,34(09):138-142.[doi:10.12174/j.issn.2096-9600.2021.09.38]
点击复制

类风湿关节炎血瘀证素量化诊断标准探索性研究
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年09期
页码:
138-142
栏目:
诊断剖析
出版日期:
2021-09-15

文章信息/Info

Title:
Exploratory Study on Quantitative Diagnostic Criteria for Syndrome Elements of Rheumatoid Arthritis of Blood Stasis Pattern
作者:
姜小帆, 李娟娥, 吉海旺, 雷鹏
陕西省人民医院，陕西 西安 710068
Author(s):
JIANG Xiaofan, LI Juane, JI Haiwang, LEI Peng
Shaanxi Provincial People’s Hospital, Xi’an 710068, China
关键词:
类风湿关节炎; 血瘀证; 证素; 最大似然判别分析法; 量化诊断标准
Keywords:
rheumatoid arthritis; blood stasis pattern; syndrome element; maximum likelihood discriminant analysis; quantitative diagnostic criteria
分类号:
R287
DOI:
10.12174/j.issn.2096-9600.2021.09.38
摘要:
目的建立类风湿关节炎（rheumatoid arthritis，RA）血瘀证素量化诊断标准。 方法运用最大似然判别分析法确定血瘀证素评定量表中各条目下属二级指标的权重，依此建立各证素量化诊断指数表。将待判患者对各条目（一级指标）的选择结果（二级指标）代入诊断指数表，分别纵向相加两列中所选数字，求出“是”和“非”两类指数和，以较大者判断其诊断为该证素或不诊断为该证素。根据临床流行病学诊断试验的评价原则，通过计算敏感度、特异度、准确度、阳性预测值、阴性预测值等指标对建立的各证素量化诊断标准进行前瞻性检验。 结果建立的各证素量化诊断标准具有较高的灵敏度和特异度，相应的漏诊率和误诊率均较低，其准确度、阳性预测值、阴性预测值结果均较理想。 结论建立的RA血瘀证素量化诊断标准具有较好的诊断效能。
Abstract:
ObjectiveTo establish the quantitative diagnostic criteria for syndrome elements of rheumatoid arthritis (RA) of blood stasis pattern. MethodsMaximum likelihood discriminant analysis was used to determine the weight of subordinate secondary indexes of each item in blood stasis syndrome element rating scale, based on this, to establish quantitative diagnostic index of each syndrome element. Substitute the selection result (secondary index) of each item (primary index) of the patients to be judged into the diagnostic index table, add the selected numbers in the two columns vertically respectively, and calculate the sum of “yes” and “non” indexes, so as to judge whether the patient is diagnosed as the syndrome element or not. According to the evaluation principle of clinical epidemiological diagnostic test, the established quantitative diagnostic criteria of each syndrome element were prospectively tested by calculating the sensitivity, specificity, accuracy, positive predictive value and negative predictive value. ResultsThe established quantitative diagnostic criteria of each syndrome element possessed higher sensitivity and specificity, the corresponding miss rate and misdiagnosis rate were lower, and the results of accuracy, positive predictive value and negative predictive value were ideal. ConclusionThe established quantitative diagnostic criteria of blood stasis syndrome elements in RA owns better diagnostic efficiency.

相似文献/References:

[1]马建辉,雷学峰,吕健△.中西医药物配合手法治疗类风湿性关节炎60例临床观察[J].西部中医药,2013,26(01):97.
　MA Jianhui,LEI Xuefeng,LV Jian.Integrative Medicine and Manipulation in the Treatment for 60 Cases of Rheumatoid Arthritis[J].Western Journal of Traditional Chinese Medicine,2013,26(09):97.
[2]张晓琴,何东初.复方玄驹胶囊联合甲氨蝶呤、来氟米特治疗类风湿关节炎40例[J].西部中医药,2012,25(05):78.
　ZHANG Xiao-qin,HE Dong-chu.Treatment of Rheumatoid Arthritis with Compound XuanJu Capsule combined with Methotrexate and Leflunomide: A Report of 40 Cases[J].Western Journal of Traditional Chinese Medicine,2012,25(09):78.
[3]王佳,王钢,王丽琴,等.秦艽醇提物治疗类风湿关节炎的实验研究[J].西部中医药,2015,28(07):11.
[4]杨华,曾娟花.血清TNF与2型糖尿病肾病及其中医证型关系的临床研究[J].西部中医药,2014,27(01):11.
　YANG Hua,ZENG Juanhua.Clinical Study on the Relationship between Serum TNF and Type 2 Diabetic Nephropathy[J].Western Journal of Traditional Chinese Medicine,2014,27(09):11.
[5]刘佳,盛丽,张宝洲,等.类风湿性关节炎膝关节病变的高频超声评价[J].西部中医药,2015,28(10):134.
[6]陈慕芝,孙红艳,照日格图△.223例类风湿关节炎患者中医证候及实验室指标分析[J].西部中医药,2016,29(05):67.
　CHEN Muzhi,SUN Hongyan,ZHAORI Getu.The Analysis of Lab Indicators and TCM Patterns of 223 Patients with Rheumatoid Arthritis[J].Western Journal of Traditional Chinese Medicine,2016,29(09):67.
[7]李拥军,郭玉荣,尹智功,等.瑶药包热敷熨对类风湿关节炎患者血清白细胞介素1β及肿瘤坏死因子α的影响[J].西部中医药,2016,29(03):61.
　LI Yongjun,GUO Yurong,YIN Zhigong,et al.Influence of Yao Medicine Package Hot Ironing Therapy on IL-1β and TNF-α of the Patients with Rheumatoid Arthritis[J].Western Journal of Traditional Chinese Medicine,2016,29(09):61.
[8]张蓓蓓,赵智明,蔡 辉△.论王清任调气活血的组方思想[J].西部中医药,2017,30(04):36.
　ZHANG Beibei,ZHAO Zhiming,CAI Hui.Study of WANG Qingren＇s Compatibility Thought of Regulating Qi and Promoting Blood Circulation[J].Western Journal of Traditional Chinese Medicine,2017,30(09):36.
[9]徐萍,章鹏,于笑霞△.通痹胶囊治疗寒湿痹阻型类风湿性关节炎35例[J].西部中医药,2017,30(08):92.
　XU Ping,ZHANG Peng,YU Xiaoxia.TongBi Capsules in Treating 35 Cases of Rheumatoid Arthritis of Cold-dampness Impediment Pattern[J].Western Journal of Traditional Chinese Medicine,2017,30(09):92.
[10]何奕坤,杨光辉△,胥晓芳,等.类风湿关节炎继发肺间质病变的中医药治疗进展[J].西部中医药,2018,31(03):140.
　HE Yikun,YANG Guanghui,XU Xiaofang,et al.TCM Therapeutic Progress of Rheumatoid Arthritis/Interstitial Lung Disease[J].Western Journal of Traditional Chinese Medicine,2018,31(09):140.

备注/Memo

备注/Memo:
姜小帆（1979—），女，博士学位，博士后。研究方向：中医风湿病学及中药新药临床评价研究。陕西省自然科学基础研究计划项目（2021JM-544）；陕西省中医药管理局中医药科研课题（15-LC038）；中国博士后科学基金会资助项目（2019M663752）。
更新日期/Last Update: 2021-09-15