[1]曾庆涛,吴红彦,王雅乐,等.基于网络药理学探讨白芍治疗阿尔茨海默病作用机制[J].西部中医药,2024,37(02):111-115.[doi:10.12174/j.issn.2096-9600.2024.02.21]
　ZENG Qingtao,WU Hongyan,WANG Yale,et al.Discussion on the Mechanism of Baishao in the Treatment of Alzheimer′s Disease Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2024,37(02):111-115.[doi:10.12174/j.issn.2096-9600.2024.02.21]
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基于网络药理学探讨白芍治疗阿尔茨海默病作用机制
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年02期
页码:
111-115
栏目:
二次研究
出版日期:
2024-02-15

文章信息/Info

Title:
Discussion on the Mechanism of Baishao in the Treatment of Alzheimer′s Disease Based on Network Pharmacology
作者:
曾庆涛1, 吴红彦1, 王雅乐1, 王斌1, 黄海1, 王虎平2
1.深圳市罗湖区中医院，深圳 罗湖 518000
2.甘肃中医药大学，甘肃 兰州 730000
Author(s):
ZENG Qingtao1, WU Hongyan1, WANG Yale1, WANG Bin1, HUANG Hai1, WANG Huping2
1.Shenzhen City Luohu District TCM Hospital, Shenzhen 518000, China
2.Gansu University of Chinese Medicine, Lanzhou 730000, China
关键词:
阿尔茨海默病; 白芍; 网络药理; 有效成分; 靶点
Keywords:
Alzheimer′s disease; network pharmacology; active ingredients; targets
分类号:
R971
DOI:
10.12174/j.issn.2096-9600.2024.02.21
文献标志码:
A
摘要:
目的利用网络药理学研究方法预测白芍治疗阿尔茨海默病的作用机制。 方法利用中药系统药理学数据库和分析平台（traditional Chinese medicine systems pharmacology database and analysis platform，TCMSP）数据库，挖掘白芍有效成分并预测其作用靶点，通过GeneCards、OMIM等数据库筛选出阿尔茨海默病形成的靶标，运用CytoScape软件构建白芍治疗阿尔茨海默病形成的“成分-靶标-通路-疾病”网络，通过STRING数据库构建靶点蛋白相关作用网络并进行关键靶点的生物功能注释及通路分析。 结果白芍13个有效成分通过干预72个靶点、4条通路发挥治疗阿尔茨海默病的作用。 结论白芍有效成分可能通过抑制炎症、调节免疫功能而达到治疗阿尔茨海默病的作用。
Abstract:
ObjectiveTo explore the mechanism of Baishao (Paeoniae radix alba) in the treatment of Alzheimer's disease (AD) using network pharmacology method. MethodsUsing TCMSP, the active ingredients of Baishao was unearthed and its action targets were predicted, AD targets were screened from OMIM and GeneCards databases, "ingredients-targets-pathway-disease" network of Baishao in the treatment of AD was formed using Cytocape software, target-protein interaction network was constructed, biological function annotation and pathway analysis of the key targets were performed via STRING database. ResultsAll 13 active ingredients of Baishao could play therapeutic roles in treating AD through intervening on 72 targets and four pathways. ConclusionThe active ingredients of Baishao could treat AD possibly through inhibiting inflammation and regulating immunologic function.

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备注/Memo

备注/Memo:
曾庆涛（1987—），男，硕士学位，主治医师。研究方向：老年病的中医药防治。广东省自然科学基金面上项目（2020A1515010217）；第七批全国老中医药专家学术经验继承工作项目（国中局〔2021〕273号）；深圳市“医疗卫生三名工程”项目（SZZYSM202201007）；罗湖区软科学研究计划项目（LX20210203）。
更新日期/Last Update: 2024-02-15