[1]孙雪,梁鹏,梁建庆,等.基于数据挖掘分析名老中医治疗帕金森病的临证经验[J].西部中医药,2024,37(03):32-38.[doi:10.12174/j.issn.2096-9600.2024.03.07]
　SUN Xue,LIANG Peng,LIANG Jianqing,et al.TCM Experts' Clinical Experience in Treating Parkinson's Disease based on Data Mining[J].Western Journal of Traditional Chinese Medicine,2024,37(03):32-38.[doi:10.12174/j.issn.2096-9600.2024.03.07]
点击复制

基于数据挖掘分析名老中医治疗帕金森病的临证经验
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年03期
页码:
32-38
栏目:
二次研究
出版日期:
2024-03-15

文章信息/Info

Title:
TCM Experts' Clinical Experience in Treating Parkinson's Disease based on Data Mining
作者:
孙雪1, 梁鹏2, 梁建庆1, 何建成3
1.甘肃中医药大学基础医学院/敦煌医学与转化教育部重点实验室，甘肃 兰州 730000
2.兰州大学第二临床医学院,甘肃 兰州 730030
3.上海中医药大学基础医学院，上海 201203
Author(s):
SUN Xue1, LIANG Peng2, LIANG Jianqing1, HE Jiancheng3
1.School of Basic Medicine, Gansu University of TCM/Key Laboratory of Education Ministry Dunhuang Medicine and Translation from Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
2.The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, China
3.School of Basic Medicine, Shanghai University of TCM, Shanghai 201203, China
关键词:
帕金森病; 中医专家; 临证经验; 数据挖掘
Keywords:
Parkinson's disease; Chinese medicine experts; clinical experience; data mining
分类号:
R256.46
DOI:
10.12174/j.issn.2096-9600.2024.03.07
文献标志码:
A
摘要:
目的运用数据挖掘技术分析名老中医治疗帕金森病（Parkinson's disease，PD）的临证经验及用药规律。 方法检索1989至2020年中国知网（China national knowledge infrastructure，CNKI）数据库收载的中医药治疗PD的相关文献，经整理、筛选后纳入符合标准的文献，运用Excel及VOS viewer软件对文献中描述的证型、舌象、脉象及中药进行数据挖掘分析。 结果本研究通过证型名称规范后得到44种证型，最常见的前三种证型分别为肝肾阴虚证28.45%（33/116）、肝风内动证6.90%（8/116）、筋脉失养证5.17%（5/116）；舌象分布：舌色以红22.86%（16/70）、暗/黯17.14%（12/70）、暗/黯红17.14%（12/70）常见，舌形以齿痕40.00%（6/15）、胖大33.33%（5/15）舌常见，苔质以薄44.00%（33/75）、腻24.00%（18/75）苔常见，苔色以黄70.21%（33/47）、白29.79%（14/47）色常见，舌下络脉以络脉青紫75.00%（3/4）、络脉色淡25.00%（1/4）常见；脉象分布：脉象以细27.63%（42/152）、弦27.63%（42/152）脉常见；中药分布：涉及中药128味，总频次为933次，高频中药主要有白芍4.61%（43/933）、天麻3.32%（31/933）、茯苓3.11%（29/933）、当归3.11%（29/933）、熟地黄3.00%（28/933）、牡蛎2.68%（25/933）、山萸肉2.57%（24/933）、全蝎2.47%（23/933）、牛膝2.25%（21/933）、龙骨2.14%（20/933）、黄芪2.14%（20/933）等。 结论PD病因病机复杂，属本虚标实证，本虚为肝肾亏损，标实为风、瘀、痰、热、毒互结，蕴塞脑窍；临床用药以补虚药为主，以平肝熄风药、活血化瘀药、祛湿化痰药为辅。
Abstract:
ObjectiveTo analyze the clinical experience of traditional Chinese medicine experts in treating Parkinson's disease (PD) using data mining. MethodsBy searching the papers related to TCM therapy for PD from CNKI between 1989 and 2020, the papers met the inclusion criteria were included after the sorting and screening, data mining of the patterns, tongue and pulse, pulse and the herbs described in the literature was performed using Excel and VOS viewer software. ResultsIn the study, 44 patterns were obtained by standardising the names of the patterns, the first three most common patterns were liver and kidney Yin deficiency pattern 28.45% (33/116), endogenous liver wind pattern 6.90% (8/116), tendon dystrophy pattern 5.17% (5/116); the distribution of tongue manifestations: the tongue color: red 22.86% (16/70), dark 17.14% (12/70), dark/dark red 17.14% (12/70), the tongue shape: with tooth marks 40.00% (6/15), and plump 33.33% (5/15); tongue coating: thin 44.00% (33/75) and greasy 24.00%(18/75), yellow 70.21% (33/47) and white 29.79% (14/47), sublingual vessel: bruise 75.00% (3/4), pale 25.00% (1/4); the distribution of pulse manifestations: thin 27.63% (42/152) and string-like 27.63% (42/152); the distribution of the herbs: 128 herbs were involved, total frequency was 933 times, high frequency herbs mainly contained Baishao (Paeoniae radix alba, 4.61%, 43/933), Tianma (Gastrodiae rhizoma, 3.32%, 31/933), Fuling (Poria, 3.11%, 29/933), Danggui (Angelicae sinensis radix, 3.11%, 29/933), Shudihuang(Rehmanniae radix praeparata, 3.00%, 28/933), Muli (Ostreae concha, 2.68%, 25/933), Shanyurou(Fructus Corni, 2.57%, 24/933), Quanxie (Scorpio, 2.47%, 23/933), Niuxi (Achyranthis bidentatae radix, 2.25%, 21/933), fossil fragments (2.14%, 20/933) and Huangqi(Astragali radix, 2.14%, 20/933). ConclusionWith the complicated cause and pathogenesis, PD belongs to the syndrome of deficiency in origin and excess in superficiality, deficiency in origin means the depletion of liver and kidney, excess in superficiality is induced by intermingled wind, stasis, phlegm, heat and toxin, obstructing the brain orifices; clinical application of the herbs mainly use the ones of tonifying the deficieny, supplemented with the ones of calming liver to stop the wind, promoting blood circulation to remove blood stasis, dispelling dampness to resolve the phlegm.

相似文献/References:

[1]李敏,杨明会.补肾活血法治疗帕金森病患者30例临床研究*[J].西部中医药,2013,26(03):1.
　LIMin,YANGMinghui.ClinicalStudyonBuShenHuoXueMethodinTreating30CasesofPatientswithParkinson'sDisease[J].Western Journal of Traditional Chinese Medicine,2013,26(03):1.
[2]盛刚,郭珍△.针刺治疗帕金森病38例[J].西部中医药,2018,31(10):108.
　SHENG Gang,GUO Zhen.Acupuncture in Treating 38 Cases of Parkinson′s Disease[J].Western Journal of Traditional Chinese Medicine,2018,31(03):108.
[3]吴林,陈静,唐农,等.基于人体阴阳本体结构理论探讨帕金森病的治疗[J].西部中医药,2022,35(02):58.[doi:10.12174/j.issn.2096-9600.2022.02.15]
　WU Lin,CHEN Jing,TANG Nong,et al.The Therapy for Parkinson′s Disease on the Foundation of Ontology Structural Theory of Human Yin and Yang[J].Western Journal of Traditional Chinese Medicine,2022,35(03):58.[doi:10.12174/j.issn.2096-9600.2022.02.15]
[4]刘秋平,张雪竹.“三焦针法”治疗帕金森病患者快速动眼睡眠行为障碍思想探微[J].西部中医药,2021,34(05):130.[doi:10.12174/j.issn.2096-9600.2021.05.33]
　LIU Qiuping,ZHANG Xuezhu.Probe into the Thinking of Treating RBD in Parkinson's Disease Patient by “Triple Energizer Acupuncture”[J].Western Journal of Traditional Chinese Medicine,2021,34(03):130.[doi:10.12174/j.issn.2096-9600.2021.05.33]
[5]孙雪,梁建庆,何建成,等.帕金森病的中医辨证治疗[J].西部中医药,2021,34(02):131.[doi:10.12174/j.issn.2096-9600.2021.02.35]
　SUN Xue,LIANG Jianqing,HE Jiancheng,et al.TCM Syndrome Differentiation Treatment of Parkinson′s Disease[J].Western Journal of Traditional Chinese Medicine,2021,34(03):131.[doi:10.12174/j.issn.2096-9600.2021.02.35]
[6]王春玲,罗宁,文晓东,等.乌梅总黄酮通过线粒体自噬对帕金森病大鼠的保护作用[J].西部中医药,2022,35(12):72.[doi:10.12174/j.issn.2096-9600.2022.12.15]
　WANG Chunling,LUO Ning,WEN Xiaodong,et al.Protective Effects of Fructus Mume Total Flavone on Rat Model with Parkinson’s Disease Through Mitophagy[J].Western Journal of Traditional Chinese Medicine,2022,35(03):72.[doi:10.12174/j.issn.2096-9600.2022.12.15]
[7]李庆,张慧,王逍,等.醒脑解郁胶囊治疗帕金森病合并抑郁30例[J].西部中医药,2024,37(06):125.[doi:10.12174/j.issn.2096-9600.2024.06.29]
　LI Qing,ZHANG Hui,WANG Xiao,et al.Treatment of Parkinson′s Disease Combined with Depression with Xingnao Jieyu Capsules: 30 Cases[J].Western Journal of Traditional Chinese Medicine,2024,37(03):125.[doi:10.12174/j.issn.2096-9600.2024.06.29]
[8]杨倩,王灿.人参皂苷Rg3减轻帕金森病小鼠神经系统氧化应激损伤的作用机制[J].西部中医药,2024,37(09):25.[doi:10.12174/j.issn.2096-9600.2024.09.06]
　YANG Qian,WANG Can.The Mechanism of Action of Ginsenoside Rg3 for the Relief from Oxidative Stress Injury in the Nervous System of Mice with Parkinson′s Disease[J].Western Journal of Traditional Chinese Medicine,2024,37(03):25.[doi:10.12174/j.issn.2096-9600.2024.09.06]
[9]邓仙勇,梁健芬,张兴博,等.从中医肝脾肾论治帕金森病的研究进展[J].西部中医药,2024,37(10):82.[doi:10.12174/j.issn.2096-9600.2024.10.18]
　DENG Xianyong,LIANG Jianfen,ZHANG Xingbo,et al.Research Progress in the Treatment of Parkinson′s Disease from Liver, Spleen and Kidney in TCM[J].Western Journal of Traditional Chinese Medicine,2024,37(03):82.[doi:10.12174/j.issn.2096-9600.2024.10.18]

备注/Memo

备注/Memo:
孙雪（1994—），女，硕士学位。研究方向：帕金森病的中医药防治。国家自然科学基金（82160929，81660767）；敦煌医学与转化教育部重点实验室开放课题（DHYX22-06）；甘肃中医药大学中青年科研基金（ZQ2015-17）；甘肃中医药大学引进人才科研启动基金（2016YJRC-07）。
更新日期/Last Update: 2024-03-15