[1]张励航,窦丹波.六郁汤治疗反流性食管炎临床疗效观察[J].西部中医药,2024,37(06):107-110.[doi:10.12174/j.issn.2096-9600.2024.06.25]
　ZHANG Lihang,DOU Danbo.Observation on Clinical Efficacy of Liuyu Tang in the Treatment of Reflux Esophagitis[J].Western Journal of Traditional Chinese Medicine,2024,37(06):107-110.[doi:10.12174/j.issn.2096-9600.2024.06.25]
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六郁汤治疗反流性食管炎临床疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年06期
页码:
107-110
栏目:
临床研究
出版日期:
2024-06-15

文章信息/Info

Title:
Observation on Clinical Efficacy of Liuyu Tang in the Treatment of Reflux Esophagitis
作者:
张励航, 窦丹波
上海中医药大学附属曙光医院，上海 201203
Author(s):
ZHANG Lihang, DOU Danbo
Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China
关键词:
食管炎; 六郁汤; 奥美拉唑; 白细胞介素6; 肿瘤坏死因子α; 胃动素
Keywords:
esophagitis; omeprazole; interleukin 6; tumor necrosis factor α; motilin
分类号:
R571
DOI:
10.12174/j.issn.2096-9600.2024.06.25
文献标志码:
B
摘要:
目的观察六郁汤治疗反流性食管炎的临床疗效。 方法选取反流性食管炎患者200例，根据不同治疗方案分为两组，每组100例。观察组给予六郁汤联合奥美拉唑治疗；对照组给予奥美拉唑治疗，两组均连续治疗8周。观察两组临床疗效、治疗期间副作用发生情况及治疗前后胃泌素（gastrin，GAS）、白细胞介素6（interleukin-6，IL-6）、肿瘤坏死因子α（tumor necrosis factor-alpha，TNF-α）、胃动素（motilin，MTL
Abstract:
ObjectiveTo observe the clinical efficacy of Liuyu Tang in the treatment of reflux esophagitis(RE). MethodsTwo hundred patients with RE were selected and divided into two groups of 100 cases each according to different treatment plans. The observation group was treated with Liuyu Tang combined with omeprazole; the control group was treated with omeprazole, and both groups were treated continuously for eight weeks. To observe the clinical efficacy, the occurrence of side effects and the changes of gastrin (GAS), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and motilin (MTL) before and after treatment in both groups. ResultsThe total effective rate of the observation group was [87.0% (87/100)], higher than [59.0% (59/100)] of the control group (P<0.05); compared with the pre-treatment period, the levels of IL-6, TNF-α, and GAS were reduced and the level of MTL was elevated in the two groups after treatment (P<0.05), and the magnitude of the above indexes decreasing or elevating in the observation group was greater than that in the control group after treatment (P<0.05). When comparing the incidences of drug side effects between the two groups, the difference was not statistically significant (P>0.05). ConclusionThe treatment of gastroesophageal reflux with Liuyu Tang can significantly improve the clinical efficacy, reduce the serum inflammatory indexes, and increase the level of motilin without increasing the adverse reactions.

相似文献/References:

[1]刘明儒.半夏泻心汤治疗反流性食管炎50例[J].西部中医药,2014,27(10):98.
[2]姚柳伊,田旭东,舒劲△.近5年反流性食管炎中医研究进展[J].西部中医药,2014,27(04):140.
　YAO Liuyi,TIAN Xudong,SHU Jin.TCM Study of Reflux Esophagitis in Recent Five Years[J].Western Journal of Traditional Chinese Medicine,2014,27(06):140.
[3]王红梅,杨小茜,刘晶,等.健脾降逆法治疗脾虚型反流性食管炎疗效评价[J].西部中医药,2019,32(08):85.
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[4]马琼,闫龙腾,赵茜,等.砂仁对反流性食管炎大鼠食管黏膜的保护作用[J].西部中医药,2023,36(10):1.[doi:10.12174/j.issn.2096-9600.2023.10.01]
　MA Qiong,YAN Longteng,ZHAO Xi,et al.The Protective Effects of Sharen on Esophageal Mucosa in Rats with Reflux Esophagitis[J].Western Journal of Traditional Chinese Medicine,2023,36(06):1.[doi:10.12174/j.issn.2096-9600.2023.10.01]

备注/Memo

备注/Memo:
张励航（1995—），男，硕士学位，医师。研究方向：中医脾胃病学临床研究。北京市社科基金青年项目（18YYC021）；北京中医药大学2020年度基本科研业务费项目重点攻关项目（2020-ZDGG-089）；北京中医药大学2020年度基本科研业务费重点攻关项目（2020-JYB-ZDGG-083）。 上海市进一步加快中医药事业发展三年行动计划项目［ZY（2018-2020）-GJHZ-1001］。
更新日期/Last Update: 2024-06-15