[1]张鑫,朱田田,魏玉婷,等.针刺调节tau蛋白过度磷酸化干预阿尔茨海默病机制的研究进展[J].西部中医药,2025,38(03):98-102.[doi:10.12174/j.issn.2096-9600.2025.03.18]
　ZHANG Xin,ZHU Tiantian,WEI Yuting,et al.Research Progress on the Mechanism of Acupuncture Intervention in Alzheimer′s Disease Via Regulation of tau Protein Hyperphosphorylation[J].Western Journal of Traditional Chinese Medicine,2025,38(03):98-102.[doi:10.12174/j.issn.2096-9600.2025.03.18]
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针刺调节tau蛋白过度磷酸化干预阿尔茨海默病机制的研究进展()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年03期
页码:
98-102
栏目:
研究进展
出版日期:
2025-03-15

文章信息/Info

Title:
Research Progress on the Mechanism of Acupuncture Intervention in Alzheimer′s Disease Via Regulation of tau Protein Hyperphosphorylation
作者:
张鑫1,2, 朱田田1, 魏玉婷1, 严兴科1
1.甘肃中医药大学针灸推拿学院，甘肃 兰州 730000
2.兰州大学第一医院，甘肃 兰州 730000
Author(s):
ZHANG Xin1,2, ZHU Tiantian1, WEI Yuting1, YAN Xingke1
1.School of Acupuncture, Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, China
2.The First Hospital of Lanzhou University, Lanzhou 730000, China
关键词:
阿尔茨海默病; 针刺; tau蛋白; 磷酸化
Keywords:
Alzheimers disease; acupuncture; tau protein; hyperphosphorylation
分类号:
R245.31
DOI:
10.12174/j.issn.2096-9600.2025.03.18
文献标志码:
A
摘要:
整理蛋白激酶糖原合成激酶3β（glycogen synthase kinase 3β，GSK-3β）、丝裂原活化蛋白激酶（mitogen-activated protein kinase，MAPK）、细胞周期蛋白依赖性激酶5（cyclin dependent kinase 5，CDK5）与磷酸酶2A（phosphothreonyl protein phosphatase 2A，PP2A）蛋白酶对微管蛋白相关单位（tubulin-associated unit，tau）蛋白磷酸化，以及针刺调节tau蛋白磷酸化的机制，系统阐述针刺干预阿尔茨海默病（Alzheimer?s disease，AD）进程中的tau蛋白磷酸化机制，为阐明针刺干预AD的tau蛋白途径提供参考。
Abstract:
By sorting out the mechanism of the effects of GSK-3β, MAPK, CDK5 and PP2A protease on tau protein hyperphosphorylation, as well as the regulation of tau protein hyperphosphorylation by acupuncture, the mechanism of tau protein hyperphosphorylation in the process of acupuncture intervention for AD was systematically elucidated, in order to provide the reference for clarifying the tau protein pathway of acupuncture intervention for AD.

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备注/Memo

备注/Memo:
张鑫（1991—），男，硕士学位，主治医师。研究方向：针灸调节效应的生物学机制研究。甘肃省高等学校青年博士基金（2021QB-072）；甘肃中医药大学引进人才科研启动基金（2019YJRC-05）。
更新日期/Last Update: 2025-03-15