[1]陈果,刘显,彭丽珊,等.复方扶芳藤合剂作为治疗性和预防性给药的选择研究[J].西部中医药,2025,38(07):12-17.[doi:10.12174/j.issn.2096-9600.2025.07.03]
　CHEN Guo,LIU Xian,PENG Lishan,et al.Study on Selection of Compound Fufangteng Mixture for Therapeutic and Preventive Administration[J].Western Journal of Traditional Chinese Medicine,2025,38(07):12-17.[doi:10.12174/j.issn.2096-9600.2025.07.03]
点击复制

复方扶芳藤合剂作为治疗性和预防性给药的选择研究()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年07期
页码:
12-17
栏目:
基础研究
出版日期:
2025-07-15

文章信息/Info

Title:
Study on Selection of Compound Fufangteng Mixture for Therapeutic and Preventive Administration
作者:
陈果1, 刘显2, 彭丽珊2, 李建明2,3, 吴展帅1,2,3, 肖健1,2
1.广西高发传染病中西医结合转化医学重点实验室，广西 南宁 530200
2.广西中医药大学，广西 南宁 530200
3.广西中医药大学教学实验实训中心，广西 南宁 530200
Author(s):
CHEN Guo1, LIU Xian2, PENG Lishan2, LI Jianming2,3, WU Zhanshuai1,2,3, XIAO Jian1,2
1.Guangxi Key Laboratory of Translational Medicine for Treating High-Incidence Infectious Diseases with Integrative Medicine, Nanning 530200, China
2.Guangxi University of Chinese Medicine, Nanning 530200, China
3.Teaching Experiment and Training Center, Guangxi University of Chinese Medicine, Nanning 530001, China
关键词:
复方扶芳藤合剂; 免疫抑制; T淋巴细胞
Keywords:
compound mixture; immunosuppression; T lymphocytes
分类号:
R289
DOI:
10.12174/j.issn.2096-9600.2025.07.03
文献标志码:
A
摘要:
目的研究复方扶芳藤合剂（compound fufangteng mixture，CFM）对环磷酰胺（cyclophosphamide，CTX）诱导的免疫抑制小鼠作为治疗性给药还是预防性给药的最佳方式。 方法将BALB/c小鼠随机分为空白组（Blank），CTX+CFM高、中、低剂量治疗组（CTX+CFM-1、2、3），CFM+CTX高、中、低剂量预防组（CFM+CTX-1、2、3），每组5只。通过腹腔注射给予Blank组生理盐水（0.02 mL/g），CTX+CFM-1、2、3通过腹腔注射给予70 mg/kg环磷酰胺，每日1次，连续3天，自第4天起，3组分别灌胃15、7.5、3.75 g/kg CFM，连续10天；CFM+CTX-1、2、3灌胃15、7.5、3.75 g/kg CFM，连续10天，自第11天起，通过腹腔注射给予70 mg/kg环磷酰胺，每日1次，连续3天。观察小鼠状态，监测小鼠体质量，检测末次小鼠血常规、胸脾指数、T淋巴细胞比例。 结果CFM+CTX预防组和CTX+CFM治疗组在改善CTX诱导的小鼠体质量、脾脏指数、T淋巴细胞比例方面无明显差异（P＞0.05），而CTX+CFM治疗组在改善免疫抑制小鼠的胸腺指数和淋巴细胞数量方面优于CFM+CTX预防组（P＜0.05）。 结论CFM作为治疗性给药，更有利于改善CTX诱导的免疫抑制小鼠的免疫状态。
Abstract:
ObjectiveTo investigate the best method of compound Fufangteng mixture (CFM) given through therapeutic or preventive administration to the mice with cyclophosphamide (CTX) induced immunosuppression. MethodsBALB/c mice were randomized into the blank group (Blank), the treatment groups of high, moderate and low doses of CTX+CFM (CTX+CFM-1, 2, 3), and the prevention groups of high, moderate and low doses of CFM+CTX (CFM+CTX-1, 2, 3), five mice in each group. Physiological saline was administered to Blank group through peritoneal injection (0.02 mL/g), CTX+CFM-1, 2 and 3 were given 70 mg/kg CTX by intraperitoneal injection, once each day, for three days in a row, from the 4th day, the three groups were given 15 g/kg, 7.5 g/kg and 3.75 g/kg CFM, for ten consecutive days. CFM+CTX-1, 2 and 3 were drenched with 15 g/kg, 7.5 g/kg and 3.75 g/kg CFM for ten days continuously, three groups accepted intraperitoneal injection of 70 mg/kg CTX since the 11th day, once each day, for three days consecutively. To observe the state of the mice, to monitor the body weight, and to detect routine blood test, spleen index and the proportions of T lymphocytes in mice. ResultsNo significant difference has been found in the improvements of body weights, spleen indexes, and the proportions of T lymphocytes in mice with CTX - induced immunosuppression between the prevention groups of CFM+CTX and the treatment groups of CTX+CFM (P>0.05), while the treatment groups of CTX+CFM was obviously better than the prevention groups of CFM+CTX in improving thymus index and the lymphocytes count in immunosuppres-sion mice (P<0.05). ConclusionCFM as preventive administration is more beneficial to improve the immune state of CTX-induced immunosuppressed mice.

相似文献/References:

[1]李雪嫣,张李峰,桂曼曼,等.复方玉屏风散对小鼠细胞免疫力的增强作用研究[J].西部中医药,2013,26(08):11.
　LI Xueyan,ZHANG Lifeng,GUI Manman,et al.Study on Compound YuPingFengSan Oral Liquid Improving Cellular Immunity of Mice[J].Western Journal of Traditional Chinese Medicine,2013,26(07):11.
[2]胡君茹,姜华△.镰形棘豆黄酮苷元对免疫抑制小鼠细胞因子的影响[J].西部中医药,2017,30(11):12.
　HU Junru,JIANG Hua.The Effects of Flavonoid Glycosides Extracted from LianXing JiDou on the Cytokines of the Immunosuppressive Mice[J].Western Journal of Traditional Chinese Medicine,2017,30(07):12.
[3]李钦,范强,胡继宏,等.富硒黄芪提取物对免疫抑制大鼠细胞因子IL-2、IL-4、IFN-γ及TNF-α的影响[J].西部中医药,2018,31(03):22.
　LI Qin,FAN Qiang,HU Jihong,et al.The Effects of Extract of Selenium-enriched Astragalus Membranaceus on Cytokines IL-2, IL-4, IFN-γ and TNF-α of Immunosuppressive Rats[J].Western Journal of Traditional Chinese Medicine,2018,31(07):22.

备注/Memo

备注/Memo:
陈果（1994—），女，硕士学位。研究方向：抗感染免疫和免疫调节。国家自然科学基金（81860780）；国家自然科学基金地区基金（82460863）；广西自然科学基金（2020GXNSFAA297162）；广西自然科学基金青年科学基金（2020GXNSFBA159064）；2018年广西中医药大学校级课题（2018QN028）；2018年广西博士科研启动金（2018BS015）。
更新日期/Last Update: 2025-07-15