[1]谢文涛,王睿,席菲菲.自拟清肝降脂汤治疗非酒精性脂肪性肝病肝郁脾虚证疗效观察[J].西部中医药,2025,38(09):108-111.[doi:10.12174/j.issn.2096-9600.2025.09.19]
　XIE Wentao,WANG Rui,XI Feifei.Clinical Observation on Selfmade Liver-clearing Lipid-lowering Decoction in the Treatment of NAFLD of Liver-Qi Stagnation and Spleen Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2025,38(09):108-111.[doi:10.12174/j.issn.2096-9600.2025.09.19]
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自拟清肝降脂汤治疗非酒精性脂肪性肝病肝郁脾虚证疗效观察()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年09期
页码:
108-111
栏目:
临床研究
出版日期:
2025-09-15

文章信息/Info

Title:
Clinical Observation on Selfmade Liver-clearing Lipid-lowering Decoction in the Treatment of NAFLD of Liver-Qi Stagnation and Spleen Deficiency Pattern
作者:
谢文涛, 王睿, 席菲菲
蒙城县中医院/亳州市第二中医院感染性疾病(肝病)科，安徽 蒙城 233500
Author(s):
XIE Wentao, WANG Rui, XI Feifei
Department of Infectious and Liver Diseases, Mengcheng County Hospital of TCM/ Bozhou City Second Hospital of TCM, Mengcheng 233500, China
关键词:
脂肪性肝病; 非酒精性; 肝功能; 肝郁脾虚证; 清肝降脂汤
Keywords:
fatty liver disease;  nonalcoholic; liver function; liver- stagnation and spleen deficiency pattern; liver-clearing lipid-lowering decoction
分类号:
R256.49
DOI:
10.12174/j.issn.2096-9600.2025.09.19
文献标志码:
B
摘要:
目的探究自拟清肝降脂汤治疗非酒精性脂肪性肝病（nonalcoholic fatty liver disease，NAFLD）肝郁脾虚证的疗效。 方法将80例NAFLD患者分成对照组和治疗组，每组40例。两组患者均在参考相关指南采取非药物干预措施的基础上，对照组口服水飞蓟宾葡甲胺片，治疗组在对照组基础上口服自拟清肝降脂汤。治疗3个月后比较两组患者肝功能［谷草转氨酶（aspartate aminotransferase，AST）、谷丙转氨酶（alanine aminotransferase，ALT）、谷氨酰转肽酶（glutamyl transpeptidase，GGT）］、血脂水平［总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）］、中医证候症状评分及临床疗效。 结果治疗后两组患者肝功能（AST、ALT、GGT）与血脂水平（TC、TG、LDL-C、HDL-C）均有所改善（P＜0.05），治疗组改善更明显（P＜0.05）；两组患者中医证候症状评分均降低，治疗组降低程度更显著（P＜0.05）；治疗组总有效率为92.50%（37/40），高于对照组的72.50%（29/40）（P＜0.05）。 结论自拟清肝降脂汤治疗NAFLD肝郁脾虚证疗效确切，能改善患者肝功能、血脂状况及中医证候。
Abstract:
ObjectiveTo explore clinical effects of selfmade liver-clearing lipid-lowering decoction in the treatment of NAFLD of liver-Qi stagnation and spleen deficiency pattern. MethodsEighty patients were allocated to the control group and the treatment group with 40 cases in each group. Both groups received non-drug interventions based on relevant guidelines, the control group were given silybin meglumine tablets and the treatment group orally took selfmade liver-clearing lipid-lowering decoction on the foundation of Western medicine. To compare liver functions including AST, ALT and GGT, the levels of blood lipid such as TC, TG, HDL-C and LDL-C, TCM syndrome scores and clinical effects between both groups after three months of the treatment. ResultsAfter the treatment, the improvements in liver functions including AST, ALT and GGT, the levels of blood lipid such as TC, TG, HDL-C and LDL-C were observed in the two groups (P<0.05), the improvements of the treatment group were more significant (P<0.05); TCM syndrome scores decreased in both groups, and the decrease was greater in the treatment group than in the control group (P<0.05); total effective rate of the treatment group was 92.50% (37/40), higher than 72.50% (29/40) of the control group (P<0.05). ConclusionSelfmade liver-clearing lipid-lowering decoction is clinically effective in the treatment of NAFLD of liver-Qi stagnation and spleen deficiency pattern, and it could improve liver function, blood lipid and TCM syndromes.

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备注/Memo

备注/Memo:
谢文涛（1981—），男，主治中医师。研究方向：中医肝病。Email：275936528@qq.com。国家自然科学基金面上项目（81720219）。
更新日期/Last Update: 2025-09-15