[1]林燕,林伟国,程变巧,等.芒硝外敷预防ERCP术后胰腺炎临床效果[J].西部中医药,2025,38(09):128-130.[doi:10.12174/j.issn.2096-9600.2025.09.24]
　LIN Yan,LIN Weiguo,CHENG Bianqiao,et al.Clinical Effects of Mirabilite for External Application in Preventing Pancreatitis after ERCP[J].Western Journal of Traditional Chinese Medicine,2025,38(09):128-130.[doi:10.12174/j.issn.2096-9600.2025.09.24]
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芒硝外敷预防ERCP术后胰腺炎临床效果()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年09期
页码:
128-130
栏目:
临床研究
出版日期:
2025-09-15

文章信息/Info

Title:
Clinical Effects of Mirabilite for External Application in Preventing Pancreatitis after ERCP
作者:
林燕1, 林伟国1, 程变巧1, 曹雯1, 李海涛2
1.厦门大学附属福州第二医院消化内科，福建 福州 350007
2.联勤保障部队第九〇〇医院消化内科，福建 福州 350025
Author(s):
LIN Yan1, LIN Weiguo1, CHENG Bianqiao1, CAO Wen1, LI Haitao2
1.Department of Gastroenterology, Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou 350007, China
2.Department of Gastroenterology, Hospital 900 of PLA Joint Logistics Support Force, Fuzhou 350025, China
关键词:
胰腺炎; 高淀粉酶血症; 内镜下逆行胰胆管造影术; 吲哚美辛; 芒硝
Keywords:
pancreatitis; hyperamylasemia; ERCP; indometacin; mirabilite
分类号:
R269
DOI:
10.12174/j.issn.2096-9600.2025.09.24
文献标志码:
B
摘要:
目的探讨芒硝外敷预防内镜下逆行胰胆管造影术（endoscopic retrograde cholangiopancreatography，ERCP）术后胰腺炎的效果。 方法回顾性分析167例ERCP术前评估为术后发生胰腺炎风险属高危患者（ERCP术后胰腺炎高危患者）的临床资料，其中95例患者ERCP术前接受吲哚美辛栓纳肛干预（吲哚美辛组），72例患者ERCP术前接受吲哚美辛栓联合术后芒硝外敷干预（吲哚美辛+芒硝组）。比较两组患者ERCP术后胰腺炎、高淀粉酶血症、腹痛、腹胀发生率及术后即刻、2 h、6 h、12 h肠鸣音次数。 结果吲哚美辛+芒硝组患者ERCP术后胰腺炎、高淀粉酶血症、腹痛、腹胀发生率分别为2.8%（2/72）、8.3%（6/72）、6.9%（5/72）和9.7%（7/72），分别低于吲哚美辛组的11.6%（11/95）、20.0%（19/95）、18.9%（18/95）和23.2%（22/95）；吲哚美辛+芒硝组患者ERCP术后2、6 h肠鸣音次数均高于吲哚美辛组（P＜0.05）。 结论芒硝外敷有助于降低ERCP术后胰腺炎和高淀粉酶血症发生率，可能与增加胃肠蠕动、减轻胃肠胀气、促进局部组织水肿消退有关。
Abstract:
ObjectiveTo discuss the effects of mirabilite for external application in the prevention of pancrea-titis after ERCP. MethodsWe respectively analyzed clinical data of 167 patients at high risk for postoperative pancreatitis in ERCP preoperative evaluation (patients at high risk of pancreatitis after ERCP), among them, 95 patients accepted indometacin suppository by rectal administration before ERCP (indometacin group), and 72 patients were given indometacin before ERCP and mirabilite for external application after the operation (indometacin+mirabilite group). To compare incidences of pancreatitis, hyperamylasemia, abdominal pain and abdominal distention after ERCP, the times of borborygmus right after the surgery, two, six and twelve hours after ERCP between the two groups. ResultsThe incidences of pancreatitis, hyperamylasemia, abdominal pain and abdominal distention after ERCP in indometacin+mirabilite group were 2.8% (2/72), 8.3%(6/72), 6.9%(5/72) and 9.7% (7/72) respectively, lower than 11.6% (11/95), 20.0% (19/95), 18.9% (18/95) and 23.2% (22/95) of indome-tacin group; the times of borborygmus two and six hours after ERCP in indometacin+mirabilite group were higher compared with indometacin group (P<0.05). ConclusionMirabilite for external use is conducive to the decrease of the incidences of pancreatitis and hyperamylasemia after ERCP, possibly related to increasing gastrointestinal motility, relieving flatulence and facilitating the resolution of local tissue edema.

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备注/Memo

备注/Memo:
林燕（1980—），女，硕士学位，主治医师。研究方向：消化内科疾病的诊治。福建省自然科学基金面上项目（2017J01321）；福州市科技计划项目（2021-S-157）。
更新日期/Last Update: 2025-09-15