[1]李建国,白璧辉,李鼎鹏,等.绝经后女性血清25羟维生素D水平与骨转换标志物相关性分析[J].西部中医药,2026,39(07):41-45.[doi:10.12174/j.issn.2096-9600.2026.07.10]
　LI Jianguo,BAI Bihui,LI Dingpeng,et al.Analysis of the Correlation between Serum 25-Hydroxyvitamin D Levels and Bone Turnover Markers in Postmenopausal Women[J].Western Journal of Traditional Chinese Medicine,2026,39(07):41-45.[doi:10.12174/j.issn.2096-9600.2026.07.10]
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绝经后女性血清25羟维生素D水平与骨转换标志物相关性分析()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年07期
页码:
41-45
栏目:
调查分析
出版日期:
2026-07-12

文章信息/Info

Title:
Analysis of the Correlation between Serum 25-Hydroxyvitamin D Levels and Bone Turnover Markers in Postmenopausal Women
作者:
李建国1,2, 白璧辉3, 李鼎鹏1,2, 贾元霞3, 苏积亮1,2, 丁聚贤1,2, 黄委委4, 林德明4, 谢兴文5
1.西北民族大学附属医院，甘肃 兰州 730030
2.甘肃省第二人民医院，甘肃 兰州 730030
3.甘肃省中医院，甘肃 兰州 730050
4.甘肃中医药大学，甘肃 兰州 730030
5.甘肃省中医院，甘肃 兰州 730050
Author(s):
LI Jianguo1,2, BAI Bihui3, LI Dingpeng1,2, JIA Yuanxia3, SU Jiliang1,2, DING Juxian1,2, HUANG Weiwei4, LIN Deming4, XIE Xingwen5
1.Affiliated Hospital of Northwest Minzu University, Lanzhou 730030, China
2.Gansu Provincial Second People’s Hospital, Lanzhou 730030, China
3.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
4.Gansu University of Chinese Medicine, Lanzhou 730030, China
5.Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730050, China
关键词:
绝经后骨质疏松症; 绝经后女性; 25羟维生素D; 骨转化标志物; 相关性分析
Keywords:
postmenopausal osteoporosis; postmenopausal women; 25-(OH)D; bone turnover markers; correlation analysis
分类号:
R681.1
DOI:
10.12174/j.issn.2096-9600.2026.07.10
文献标志码:
A
摘要:
目的探讨不同骨量绝经后女性血清25羟维生素D［25-hydroxyvitamin D，25-（OH）D］水平与血清骨转换标志物（bone turnover markers，BTMs）间的相关性，为制定早期防治策略提供依据。 方法通过横断面调查对兰州市45岁以上社区常住女性进行问卷调查，采用双能X线吸收法（dual-energy X-ray absorptiometry，DXA）测定骨密度（bone mineral density，BMD），收集患者清晨空腹血清并检测25-（OH）D、骨钙素（osteocalcin，OST）、甲状旁腺素（parathyroid hormone，PTH）、碱性磷酸酶（alkaline phosphatase，ALP）、β-Ⅰ型胶原羧基端肽（β-crosslinked C-terminal telopeptide of typeⅠcollagen，β-CTX）、Ⅰ型前胶原N端前肽（procollagen typeⅠN-terminal propeptide，PINP）水平，采用Spearman相关分析观察指标间的相关性。 结果1）兰州地区45岁以上绝经后女性骨量减少检出率50.25%，绝经后骨质疏松症（postmenopausal osteoporosis，PMOP）患病率35.91%；2）骨量正常组的血清25-（OH）D与OST、PTH、ALP、β-CTX、PINP无相关性（P＞0.05）；骨量减少组的血清25-（OH）D与PTH呈负相关（r=-0.20，P＜0.01）；PMOP组的血清25-（OH）D与PTH、ALP呈负相关（r=-0.19，P＜0.01；r=-0.14，P＜0.05）。 结论血清25-（OH）D与PTH、ALP关系密切，检测PMOP患者血清25-（OH）D水平可反映机体PTH、ALP水平。
Abstract:
ObjectiveTo investigate the correlation between serum 25-hydroxyvitamin D [25-(OH)D] levels and serum bone turnover markers (BTMs) in postmenopausal women with different bone mass statuses, and to provide a basis for the development of early prevention and treatment strategies. MethodsA cross-sectional survey was conducted among community-dwelling female residents aged 45 years and older in Lanzhou City. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DXA). Fasting morning serum samples were collected to measure levels of 25-(OH)D, osteocalcin (OST), parathyroid hormone (PTH), alkaline phosphatase (ALP), β-crosslinked C-terminal telopeptide of type I collagen (β-CTX), and procollagen type I N-terminal propeptide (PINP). Spearman correlation analysis was used to examine the correlations among these parameters. Results1) The detection rate of osteopenia among postmenopausal women aged over 45 years in the Lanzhou area was 50.25%, and the prevalence of postmenopausal osteoporosis (PMOP) was 35.91%; 2) In the normal bone mass group, serum 25-(OH)D showed no correlation with OST, PTH, ALP, β-CTX, or PINP (P0.05). In the osteopenia group, serum 25-(OH)D was negatively correlated with PTH (r = -0.20, P0.01). In the PMOP group, serum 25-(OH)D was negatively correlated with PTH and ALP (r = -0.19, P 0.01; r = -0.14, P0.05, respectively). ConclusionSerum 25-(OH)D is closely correlated with PTH and ALP. Measuring serum 25-(OH)D levels in patients with PMOP may reflect the levels of PTH and ALP in the body.

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备注/Memo

备注/Memo:
国家自然科学基金地区科学基金项目（81860864，82160911）；甘肃省自然科学基金（25JRRA834，24JRRA1159，23JRRA1787）；兰州市科技计划项目（2022-3-9，2025-2-101）。李建国（1989—），男，硕士学位，硕士研究生导师，主治医师。研究方向：骨伤科疾病的中医药防治及研究。
更新日期/Last Update: 2026-07-15