[1]王凤清,刘艳春.艾迪注射液联合CAG方案治疗老年急性髓细胞白血病40例疗效观察[J].西部中医药,2012,25(12):85-87.
 WANG Feng-qing,LIU Yan-chun.Observation on AiDi Injection and CAG Plan in Treating 40 Cases of Senile Acute Myelocytic Leukemia[J].Western Journal of Traditional Chinese Medicine,2012,25(12):85-87.
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艾迪注射液联合CAG方案治疗老年急性髓细胞白血病40例疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年12期
页码:
85-87
栏目:
出版日期:
2012-12-15

文章信息/Info

Title:
Observation on AiDi Injection and CAG Plan in Treating 40 Cases of Senile Acute Myelocytic Leukemia
文章编号:
1004-6852(2012)12-0085-03
作者:
王凤清1刘艳春2
1 唐山市丰南区医院,河北 唐山 063300;2 唐山市工人医院
Author(s):
WANG Feng-qing1 LIU Yan-chun2
1 Tangshan Municipality Fengnan District Hospital, Tangshan 063300, China; 2 Tangshan Municipality Labor Hospital
关键词:
髓细胞白血病急性化疗老年人
Keywords:
myelocytic leukemia acute radiotherapy the elderly
分类号:
R733.71
文献标志码:
B
摘要:
目的:观察艾迪注射液联合CAG方案治疗老年急性髓细胞白血病的疗效及安全性。方法:将80例患者随机分为观察组和对照组各40例。2组均采用CAG方案:阿糖胞苷(Ara-c)10mg/m2,皮下注射q12h(第1-14天);阿克拉霉素(Acla)10-14mg/(m2·d),静脉注射(第1-4天);粒系集落刺激因子(G-CSF)200μg/(m2·d),皮下注射(第1-14天)。观察组同时加用艾迪注射液50mL/d,静脉滴注(第1-14天)。结果:完全缓解率观察组75.00%,对照组62.50%,2组差异显著(P<0.05);总有效率观察组85.00%,对照组75.00%,2组差异显著(P<0.05)。1年生存率观察组为65.00%,对照组为45.00%,2组相比差异显著(P<0.05);3年生存率观察组为37.50%,对照组为25.00%,2组相比差异显著(P<0.05)。身心健康、心理健康、社会关系、环境因素等指标治疗后观察组分别(25.7±6.2)(23.3±3.7)(23.7±6.4)(22.4±4.6)分,对照组分别为(15.7±6.2)(14.3±3.7)(14.7±6.4)(17.4±4.6)分,2组均明显好转(P<0.05),观察优于对照组(P<0.05)。结论:艾迪注射液联合CAG方案治疗老年急性髓细胞白血病疗效确切,相对安全,耐受性好。
Abstract:
Objective: To observe clinical effects and safety of AiDi injection and CAG plan in treating senile acute myelocytic leukemia. Method: Eighty Patients were randomly divided into observation group and control group equally. Both groups received CAG plan: cytosine arabinoside (Ara-c) 10 mg/m2, subcutaneous injection q12h, from the first to 14th day; Aclacinomycin (Acla) 10 to 14 mg/(m2·d), intravenous dripping from the 1st to 4th day; granulocyte-colony stimulating factor (G-CSF), 200 μg/ (m2·d), subcutaneous injection, from the first to 14th day. Observation group were also given with intravenous dripping of AiDi injection from the 1st to 14th day,50mL/d. Result: Total remission rate of observation group was 75.00%, higher than 62.50% of control group with significant difference (P<0.05); total effective rate of observation group was 85.00%, superior to 75.00% with significant difference (P<0.05). One-year survival rate of observation group was 65.00%, higher than 45.00% of control group with significant difference (P<0.05); three-year survival rate of observation group was 37.50%, higher than 25.00% of control group with significant difference (P<0.05). Scales of observation group were (25.7±6.2),(23.3±3.7), (23.7±6.4) and (22.4依4.6) in physical and mental health, mental health, social relations, environmental factors and others indexes, superior to (15.7±6.2), (14.3±3.7), (14.7±6.4) and (17.4±4.6) of control group (P<0.05),both groups improved remarkably (P<0.05). Conclusion:AiDi injection and CAG plan are effective and safe in treating senile acute myelocytic leukemia with high tolerance.

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备注/Memo

备注/Memo:
收稿日期:2012-09-27 作者简介:王凤清(1972—),男,主治医师。研究方向:血液疾病的诊治。
更新日期/Last Update: 1900-01-01