[1]邓 毅,任鹏飞,张艳萍△.甘肃不同产地当归对大鼠雌性激素及子宫的影响*[J].西部中医药,2013,26(03):10-13.
 DENG Yi,REN Pengfei,ZHANG Yanping.Effects of DangGui from Different Producing Areas of Gansu on the Uterus and Female Hormone of Rats[J].Western Journal of Traditional Chinese Medicine,2013,26(03):10-13.
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甘肃不同产地当归对大鼠雌性激素及子宫的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年03期
页码:
10-13
栏目:
方药·道地药材
出版日期:
2013-03-15

文章信息/Info

Title:
Effects of DangGui from Different Producing Areas of Gansu on the Uterus and Female Hormone of Rats
文章编号:
1004-6852(2013)03-0010-04
作者:
邓 毅12任鹏飞1张艳萍3△
1 甘肃中医学院,甘肃 兰州 730000;2 甘肃省中药药理与毒理学重点实验室; 3 甘肃中医学院附属医院
Author(s):
DENG Yi12 REN Pengfei1 ZHANG Yanping3△
1 Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; 2 Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicines of Gansu Province; 3 University Hospital of Gansu Traditional Chinese Medicine
关键词:
甘肃当归雌性激素子宫比较
Keywords:
Gansu DangGui(A ngelica sinensis) female hormone uterus compare
分类号:
R285.5
文献标志码:
A
摘要:
目的:比较甘肃不同产地当归对雌性大鼠雌性激素及子宫的影响。方法:采用 Elisa 酶联免疫反应吸附法、重量法、离体子宫法,分别以雌二醇(E2)、促卵泡激素(FSH)、促黄体生成素(LH)、泌乳素(PRL)、卵巢指数、子宫指数及张力、活动力抑制率为指标,观察不同产地当归作用的强弱。结果:与生理盐水组比较,甘肃各当归组均能显著提高大鼠血清 E2的浓度(P<0.01);降低大鼠血清 LH 的浓度,渭源当归作用显著(P<0.01),岷县、临夏当归作用明显(P<0.05);有降低大鼠血清 FSH、PRL 浓度的趋势;提高大鼠子宫指数方面渭源、岷县、礼县当归作用显著(P<0.01),临夏当归作用明显(P<0.05);提高大鼠卵巢指数方面岷县、渭源当归作用显著(P<0.01),礼县、临夏当归作用明显(P<0.05);在降低大鼠离体子宫的频率抑制率(P<0.05)及降低大鼠离体子宫的张力抑制率,礼县、临夏、渭源当归作用显著(P<0.01),岷县当归作用明显(P<0.05)及降低大鼠离体子宫的活动力抑制率方面礼县、临夏、渭源当归作用显著(P<0.01),岷县当归作用明显(P<0.05)。结论:甘肃不同产地当归对大鼠雌性激素及子宫功能均具有不同程度的影响,综合比较以岷县、渭源当归作用较强。
Abstract:
Objective: To compare the effects of DangGui (Angelica sinensis) from different producing areas of Gansu on the uterus and female hormone of rats. Method: Elisa absorption method, gravimetric method and isolated uterus were adopted to observe the function of DangGui from different producing areas by taking estradiol (E2),follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), ovary index, uterine index and tension, activity inhibition ratio as targets. Result: Compared with group of physiological saline, the concentrations of E2 were significantly raised in the groups of Gansu DangGui (P< 0.01); the concentration of serum LH were lowered and WeiYuan DangGui was more effective(P< 0.01), MinXian and LinXia DangGui were effectiv(P< 0.05);showing the tendency of lowering the concentrations of serum FSH, PRL in rats; WeiYuan, MinXian and LiXian DangGui also performed the function of raising uterine index notably (P< 0.01), LinXia DangGui raised uterine index obviously (P<0.05); MinXian and WeiYuan DangGui could raise ovary index of rats significantly (P< 0.01),LiXian and LinXia DangGui could did obviously (P< 0.05); LiXian, LinXia and W eiY uan DangGui could decrease frequency inhibition rate of isolated uterus (P< 0.05) and tension inhibition rate (P< 0.01), Minxian DangGui could did obviously (P< 0.05); LiXian, LinXia and WeiYuan DangGui could decrease activity inhibition ratio of isolated uterus in rats significantly(P< 0.01), MinXian DangGui showed the function obviously (P< 0.05). Conclusion: Gansu DangGui from different producing areas shows different effects on uterine function and female hormone of rats,among them, comprehensive function of MinXian and WeiYuan DangGui are the stronger.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-11-07 * 基金项目:甘肃省财政厅高校科研项目(编号 2009-4) 作者简介:邓毅(1964—),男,博士研究生导师,教授,中药学学科学术带头人。研究方向:中药及复方的应用研究及教学。 △通讯作者:张艳萍(1964—),女,副主任技师。研究方向:心电技能检查与诊断。
更新日期/Last Update: 2013-03-15