[1]周明旺,柳海平,李盛华△,等.阳虚质膝骨性关节炎关节软骨中PKC的表达研究[J].西部中医药,2017,30(10):1-3.
　ZHOU Mingwang,LIU Haiping,LI Shenghua,et al.The Research on the Expression of PKC in Arthrodial Cartilage of the Patients with Knee Osteoarthritis of Yang Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2017,30(10):1-3.
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阳虚质膝骨性关节炎关节软骨中PKC的表达研究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年10期
页码:
1-3
栏目:
出版日期:
2017-10-15

文章信息/Info

Title:
The Research on the Expression of PKC in Arthrodial Cartilage of the Patients with Knee Osteoarthritis of Yang Deficiency Pattern
文章编号:
1004-6852(2017)10-0001-03
作者:
周明旺1，柳海平1，李盛华1△，潘文2，王晓萍1，乔斌3，敬平福3，付志斌1
1 甘肃省中医院，甘肃 兰州 730050； 2 甘肃省中医药研究院； 3 甘肃中医药大学
Author(s):
ZHOU Mingwang1, LIU Haiping1, LI Shenghua1△, PAN Wen2, WANG Xiaoping1, QIAO Bin3, JING Pingfu3, FU Zhibin1
1 Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu Provincial Academy of Chinese Medicine; 3 Gansu University of Traditional Chinese Medicine
关键词:
膝骨性关节炎; 阳虚质; 蛋白激酶C
Keywords:
knee osteoarthritis;  Yang deficiency pattern;  protein kinase C
分类号:
R684.3
文献标志码:
A
摘要:
目的：研究阳虚质膝骨性关节炎(Knee Osteoarthritis，KOA)与蛋白激酶C(PKC)表达之间的相关性。方法：从病例调查数据库中随机选取KOA病例共20例，其中非阳虚质KOA患者10例，阳虚质KOA患者10例；非KOA健康志愿者10例作为对照组。采用免疫组化及RT-PCR方法检测PKC在不同组别中的表达。结果：PKC在正常关节软骨及阳虚质KOA与非阳虚质KOA中均有表达，表达主要位于细胞浆及细胞核内，组间进行两两比较，差异有统计学意义(P＜0.05)；PKC基因在对照组与KOA病例组关节软骨组织中的表达进行比较，差异有统计学意义(P＜0.01)；PKC基因在阳虚质病例组、非阳虚质病例组与对照组进行两两比较差异有统计学意义(P＜0.05)。结论：PKC基因与KOA的发病有一定相关性，且可能与阳虚质高发KOA有一定联系。
Abstract:
Objective: To study the relativity between knee osteoarthritis (KOA) of Yang deficiency pattern and PKC expressions. Methods: All 20 KOA cases were randomly chosen from case investigation database, among them, there were ten cases with KOA of non Yang deficiency pattern and ten cases with KOA of Yang deficiency pattern; and ten non-KOA healthy volunteers were taken as the control group. The expressions of PKC in different groups were detected by using immunohistochemical method and RT-PCR method. Results: There were the expressions of PKC in normal arthrodial cartilage, KOA of Yang deficiency pattern and KOA of non Yang deficiency pattern, it mainly expressed in cytoplasm and nucleus, the difference showed statistical meaning in the comparisons among the groups (P＜0.05); the difference had statistical meaning in the comparisons of the expressions of PKC in arthrodial cartilage between the control group and KOA case group (P＜0.05); the case group of Yang deficiency pattern and the case group of non Yang deficiency pattern were compared with the control group in the expressions of PKC gene,and the differences had statistical meaning (P＜0.05). Conclusion: PKC gene is related to the incidence of KOA, and it might be related to the high incidence of KOA of Yang deficiency pattern to a certain degree.

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备注/Memo

备注/Memo:
收稿日期：2017-02-10 *基金项目：国家自然科学基金(编号81260546)；甘肃省自然科学基金(编号1208RJYA041)；甘肃省中医药管理局科研课题(编号GZK-2015-10)。 作者简介：周明旺(1977—)，男，博士学位，副主任医师。研究方向：骨关节疾病的中医药防治。 △通讯作者：李盛华（1959—），男，主任医师，教授、博士研究生导师，卫生部有突出贡献的中青年专家，国务院政府特殊津贴专家，中华骨伤名师，国家科技奖评审专家，国家自然科学基金评审专家，国家中医药管理局医师资格评审委员会评审专家，甘肃省优秀专家，甘肃省名中医，甘肃省领军人才（第一层次）。兼任中国中西医结合学会骨科微创专业委员会主任委员，中华中医药学会骨伤分会副主任委员，中国中医药研究促进会中医学术流派分会常务委员，中国医院协会中医医院分会常务委员，甘肃省中医药学会骨伤专业委员会主任委员，甘肃省中西医结合学会骨科微创专业委员会主任委员，甘肃省骨伤科临床医学中心主任，《中国中医骨伤科杂志》副主编，《西部中医药》杂志编委会副主任，《西部微创骨科》杂志主编，《中医正骨》《中国骨伤》杂志编委，甘肃陇中正骨学术流派传承工作室负责人。研究方向：中医药防治骨关节疾病。
更新日期/Last Update: 2017-10-15