[1]赵建民.姜黄-茴香胶囊治疗肠易激综合征70例[J].西部中医药,2018,31(12):63-65.
 ZHAO Jianmin.JiangHuang-HuiXiang Capsules in Treating 70 Cases of Irritable Bowel Syndrome[J].Western Journal of Traditional Chinese Medicine,2018,31(12):63-65.
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姜黄-茴香胶囊治疗肠易激综合征70例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年12期
页码:
63-65
栏目:
报道·临证经验
出版日期:
2018-12-15

文章信息/Info

Title:
JiangHuang-HuiXiang Capsules in Treating 70 Cases of Irritable Bowel Syndrome
文章编号:
1004-6852(2018)12-0063-03
作者:
赵建民
陇县中医院,陕西 陇县 721200
Author(s):
ZHAO Jianmin
Longxian County TCM Hospital, Longxian 721200, China
关键词:
肠易激综合征姜黄-茴香复合物炎症因子生活质量
Keywords:
irritable bowel syndrome JiangHuang-Huixiang compounds inflammatory factors quality of life
分类号:
R516.1
摘要:
目的:观察姜黄-茴香胶囊对肠易激综合征(IBS)的临床疗效。方法:将70例患者随机均分为观察组和对照组各35例。观察组给予姜黄-茴香胶囊,口服,2粒/次,2次/d治疗,对照组给予匹维溴铵片,口服,50 mg/次,2次/d治疗,2 组均连续治疗1个月。比较2组临床疗效、血清炎症因子[白细胞介素10(IL-10)、白细胞介素17(IL-17)和肿瘤坏死因子α(TNF-α)、症状积分和不良反应发生情况。结果:总有效率观察组为91.4%,对照组为65.7%,2组比较差异有统计学意义(P<0.05)。IBS严重程度量表(IBS-SSS)和IBS生活质量量表(IBS-QoL)评分治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异也有统计学意义(P<0.05)。血清炎症因子IL-10、IL-17和TNF-α水平治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异也有统计学意义(P<0.05)。2组均未出现严重不良反应事件。结论:姜黄-茴香胶囊治疗IBS疗效显著,可改善生活质量,其机制可能与抑制IBS患者促炎症因子TNF-α、IL-17的释放,促进抑炎症因子IL-10的释放有关。
Abstract:
Objective:To survey clinical effects of JiangHuang-Huixiang capsules in the treatment for irritable bowel syndrome (IBS). Methods: Seventy patients were randomized into the observation group and the control group, 35 cases each group. The observation group were treated by oral administration of JiangHuang-Huixiang capsules, two pills each time, twice each day and the control group accepted oral administration of pivemine bromide tablets, 50 mg each time, twice each day. both groups were treated for one month consecutively. The incidence of adverse reaction, symptom scores, serum inflammatory factors including IL-10, IL-17 and TNF-α and clinical effects of both groups were compared. Results: Total effective rate of the observation group was 91.4%, higher than 65.7% of the control group, and the difference showed statistical meaning (P<0.05). The difference had statistical meaning in the comparison of IBS-SSS and IBS-QOL scores within two groups before and after treating (P<0.05); the difference was statistically significant in the comparisons between both groups after treating (P<0.05). The difference had statistical meaning in the comparison of the levels of IL-10, IL-17 and TNF-α within two groups before and after treating(P<0.05); the difference showed statistical meaning in the comparisons between both groups after treating(P<0.05). No severe adverse reaction happened in both groups. Conclusion: JiangHuang-Huixiang capsules in the treatment for IBS could obtain notable effects and improve quality of life, and the mechanism might be related to inhibiting the release of IL-17 and TNF-α of IBS patients and promoting the release of IL-10.

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备注/Memo

备注/Memo:
收稿日期:2018-04-27 作者简介:赵建民(1969—),男,副主任医师。研究方向:内科疾病的中医诊治。
更新日期/Last Update: 2018-12-15