[1]曾海生,周歧骥,覃洪含,等.生、熟大黄对大承气汤泻下作用的比较研究[J].西部中医药,2021,34(02):18-21.[doi:10.12174/j.issn.2096-9600.2021.02.05]
　ZENG Haisheng,ZHOU Qiji,QIN Honghan,et al.Comparative Study on the Influence of Raw and Prepared Rhubarb on Laxative Effects of Dachengqi Decoction[J].Western Journal of Traditional Chinese Medicine,2021,34(02):18-21.[doi:10.12174/j.issn.2096-9600.2021.02.05]
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生、熟大黄对大承气汤泻下作用的比较研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年02期
页码:
18-21
栏目:
出版日期:
2021-02-15

文章信息/Info

Title:
Comparative Study on the Influence of Raw and Prepared Rhubarb on Laxative Effects of Dachengqi Decoction
作者:
曾海生1, 周歧骥1, 覃洪含2, 郭小葆1, 林瑶2, 何思陆1
1.右江民族医学院附属医院，广西 百色 533000
2.右江民族医学院
Author(s):
ZENG Haisheng1, ZHOU Qiji1, QIN Honghan2, GUO Xiaobao1, LIN Yao2, HE Silu1
1.Affiliated Hospital of Youjiang Medical University for Nationalites, Baise 533000, China
2.Youjiang Medical University for Nationalites
关键词:
大承气汤; 大黄; 泻下作用; 动物实验
Keywords:
decoction; rhubarb; laxative effects; animal experiments
分类号:
R285.5
DOI:
10.12174/j.issn.2096-9600.2021.02.05
摘要:
目的研究生、熟大黄对大承气汤泻下作用的影响。 方法将72只小鼠随机分为空白对照组、阳性对照组及生、熟大黄大承气汤低（6 g/kg）、高（10 g/kg）剂量组，共6组，每组12只。分别用代谢笼积分法、炭末推进作用及Na+-K+-ATPasc活性实验，比较各组泻下作用、炭末推进率及Na+-K+-ATPasc活性的差异。 结果生大黄大承气汤组、熟大黄大承气汤组与空白对照组及阳性对照组比较，其对正常小鼠泻下作用、炭末推进作用、抑制Na+-K+-ATPase活性的作用差异均有统计学意义（P＜0.05），且生大黄大承气汤各组与熟大黄同剂量组比较泻下作用更显著（P＜0.05），并与给药剂量成正相关。 结论生、熟大黄对大承气汤泻下作用的影响差异有统计学意义，这可能与君药生、熟大黄的主要化学成分含量变化引起大承气汤复方中蒽醌类化合物的溶出量变化有关。
Abstract:
ObjectiveTo study the impacts of raw and prepared rhubarb on laxative effects of Dachengqi decoction. MethodsAll 72 mice were randomized into blank control group, positive control group, low (6g/kg) and high (10g/kg) doses groups of raw and prepared rhubarb Dachengqi decoction, six groups altogether, 12 mice each group. To compare the difference in laxative effects, advance rate of carbon powder and Na+-K+-ATPasc activity in different groups using metabolic cage integral method, carbon powder propulsion and Na+-K+-ATPasc activity experiment respectively. ResultsWhen raw rhubarb Dachengqi decoction group and prepared rhubarb Dadnenggi decoction group were compared with blank control group and positive control group, the differences existed in their effects on laxative effects, advance rate of carbon powder and inhibiting Na+-K+-ATPasc activity (P<0.05), laxative effects were more notable when the groups of raw rhubarb Dachengqi decoction were compared with equivalent dose groups of prepared rhubarb (P<0.05), and it was positively related to medication dose. ConclusionThe impacts of raw and prepared rhubarb are different on laxative effects of Dachengqi decoction, and this might be related to the changes in the dissolution of anthraqui-nones of Dachengqi decoction induced by the changes of main chemical ingredients in monarch raw and prepared rhubarb.

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备注/Memo

备注/Memo:
曾海生（1984—），男，硕士学位，主管药师。研究方向：中药质量标准的研究与建立。国家自然科学基金（81360524）；广西自然科学基金（2016GXNSFAA380148）；广西中药药效研究重点实验室（17-259-200）；右江民族医学院校级科研课题（yy2018ky018）；广西壮族自治区食品药品监督管理局课题（YTT17003）；国家中医药管理局科研三级实验室中（壮）药化学与质量分析实验室［国中医药发2009（21）号］。
更新日期/Last Update: 2021-02-15